L-Norvaline
Basic information
- CAS
6600-40-4- Standard SMILES
CCC[C@H](N)C(=O)O- InChIKey
SNDPXSYFESPGGJ-BYPYZUCNSA-N- Molecular formula
- C5H11NO2
- Average molar mass
- 117.15 g/mol
- Monoisotopic mass
- 117.07897859
Overview
L-2-aminopentanoic acid is a 2-aminopentanoic acid that has S-configuration. It has a role as a hypoglycemic agent, a neuroprotective agent and a bacterial metabolite. It is an enantiomer of a D-2-aminopentanoic acid. It is a tautomer of a L-2-aminopentanoic acid zwitterion.
Names & identifiers
- Preferred name
- L-Norvaline
- IUPAC
- (2S)-2-aminopentanoic acid
- English name
- L-Norvaline
- Molecular formula
- C5H11NO2
- Molecular weight
- 117.15
Names & synonyms
L-norvalinenorvaline6600-40-4(S)-2-Aminopentanoic acid(2S)-2-aminopentanoic acidL-2-Aminovaleric acidL-2-aminopentanoic acidA70UKS48FECHEBI:18314DTXSID701018015NSC-203786alpha-Aminovaleric acid
Show more names
L-Nva-OH2-AMINOPENTANOIC ACIDNVAL-NorvaLNval-OHL-NVal-OHH-L-NVA-OH
RefChem:854766(2S)-2-azaniumylpentanoateDTXCID801476214229-543-3h-nva-ohL-2-aminopentanoate(S)-2-Aminovaleric acidMFCD00064421
Database identifiers
- CAS
6600-40-4、760-78-1- PubChem CID
- 65098
- DTXSID
DTXSID701018015- ChEMBL
CHEMBL55612- ChEBI
CHEBI:18314- UNII
- A70UKS48FE
- EC Number
- 229-543-3
- Nikkaji
- J9.213D
Properties
Computed structural properties
- XLogP
- -2.1
- Topological polar surface area
- 63.3 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 3
- Heavy atoms
- 8
- Formal charge
- 0
- Complexity
- 82.5
Experimental & physicochemical properties
DrugsPharmaceuticals -> Listed in ZINC15
LipidsFatty Acyls [FA] -> Fatty Acids and Conjugates [FA01] -> Amino fatty acids [FA0110]
CosmeticsAntistatic
Collision Cross Section
142 Ų [M-H]- [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]
133 Ų [M+Na]+
Physicochemical properties
- Melting point
- 300 °C · >300 °C(lit.)
- alpha
- 24.5 · 24.5 º (c=10, 6 N HCl)
- Boiling point
- 222.9 · 222.9±23.0 °C(Predicted)
- Density
- 1.2 · 1.2000 (estimate)
- refractive index
- 25 ° · 25 ° (C=10, 6mol/L HCl)
- storage temp.
- 30 °C · Store below +30°C.
- solubility
- 48.7 g/l · 48.7g/l
- form
- Fine Crystalline Powder
- pka
- 2.32 · 2.32(at 25℃)
- color
- White
- optical activity
- 7.025 · +7.025 (H2O) +24.125 (5 mol dm-3 HCl)
- Water Solubility
- 10.5 g/100 · 10.5 g/100 mL (18 ºC)
- Merck
- 14 · 14,6716
- BRN
- 1721162 · 1721162
- Major Application
- detection
- Cosmetics Ingredients Functions
- ANTISTATIC
- InChI
- 1S/C5H11NO2/c1-2-3-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
- InChIKey
- SNDPXSYFESPGGJ-BYPYZUCNSA-N
- SMILES
- CCC[C@H](N)C(O)=O
- CAS DataBase Reference
- 6600 · 6600-40-4(CAS DataBase Reference)
- EWG's Food Scores
- 1 · 1
- FDA UNII
- 70 UKS48FE · A70UKS48FE
- NIST Chemistry Reference
- L-Norvaline(6600-40-4)
- UNSPSC Code
- 12352209 · 12352209
- NACRES
- 26 · NA.26
- Symbol(GHS)
- 5 · GHS05,GHS07,GHS09
- Signal word
- Warning
- Hazard statements
- 402 · H402
- Precautionary statements
- 501 · P501-P273
- PPE
- 95 · Eyeshields, Gloves, type N95 (US)
- Hazard Codes
- C,Xn
- Risk Statements
- 20 · 20/21/22-36/37/38
- Safety Statements
- 24 · 24/25-37/39-26
- WGK Germany
- 3 · 3
- HS Code
- 29224995 · 29224995
- Storage Class
- 11 · 11 - Combustible Solids
- REACH Registrations
- Active
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 75% (6 of 8) of all reports.
Warning
H315 (25%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 8 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory InformationStatus: Active Update: 22-05-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/23649
Hazard Classes and CategoriesSkin Irrit. 2 (25%)
Safety data
- PPE
- Eyeshields, Gloves, type N95 (US)
- wgk
- 3
- hs_code
- 29224995
- risk_code
- 20/21/22-36/37/38
- Signal word
- Warning
- Symbol(GHS)
- GHS05,GHS07,GHS09
- hazard_code
- C,Xn
- safety_code
- 24/25-37/39-26
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H402
- REACH Registrations
- Active
- Precautionary statements
- P501-P273
Chemistry & industry
Uses & manufacturing
Use ClassificationCosmetics -> Antistatic
General Manufacturing InformationNorvaline: ACTIVE
Applications
DescriptionL-Norvaline, an amino acid nutritional supplements, is a nonessential amino acid that’s typically found in protein-rich foods, such as meat and eggs. And, it can also be made by the body from valine during normal metabolism. L-norvaline is frequently consumed by athletes as part of their workout supplement program. It is usually used for pre-workout drinks to boost energy and support post-workout recovery. During workouts, L-norvaline improves muscle tissue strength and endurance by providing massive amounts of oxygen and nutrients.
UsesL-Norvaline is a protein amino acid used as a skin-conditioning and anti-static agent. It is also used in method for reducing misincorporation of non-canonical branched-chain Amino Acids into recombinant proteins.
Upstream & downstream products
Downstream products
Additional notes
DefinitionChEBI: L-Norvaline is a 2-aminopentanoic acid that has S-configuration. It has a role as a bacterial metabolite. It is a (R)-fenbuconazole and a 2-aminopentanoic acid. It is an enantiomer of a D-2-aminopentanoic acid. It is a tautomer of a L-2-aminopentanoic acid zwitterion.
Related reactions
25 records
Compound notes
Loading…