N,N-Bis(trimethylsilyl)trifluoroacetamide

HCID 65279

Notes Reactions

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Basic information

CAS: 21149-38-2
Standard SMILES: C[Si](C)(C)N(C(=O)C(F)(F)F)[Si](C)(C)C
InChIKey: RZYHXKLKJRGJGP-UHFFFAOYSA-N
Molecular formula: C8H18F3NOSi2
Average molar mass: 257.4 g/mol
Monoisotopic mass: 257.08790192

Names & identifiers

Preferred name: N,N-Bis(trimethylsilyl)trifluoroacetamide
IUPAC: 2,2,2-trifluoro-N,N-bis(trimethylsilyl)acetamide
English name: Bis(trimethylsilyl) sulfate
Molecular formula: C8H18F3NOSi2
Molecular weight: 257.4

Names & synonyms

21149-38-2Acetamide, 2,2,2-trifluoro-N,N-bis(trimethylsilyl)-N,N-Bis(Trimethylsilyl)trifluoroacetamide5T8NA426KZN,N-Bis(trimethylsilyl)-2,2,2-trifluoroacetamideDTXSID8066682Trimethylsilyl N-trimethylsilyltrifluoroacetimidateRefChem:822183DTXCID4036433244-242-72,2,2-Trifluoro-N,N-bis(trimethylsilyl)acetamideN,N-BSTFA

Show more names

BIS(TRIMETHYLSILYL)SULPHATE2,2,2-trifluoro-n,n-bis(trimethylsilyl)-acetamid2,2,2-trifluoro-N,N-bis(trimethylsilyl)-Acetamidetrimethylsilyln-trimethylsilyltrifluoroacetimidate2,2,2-trifluoro-N,N-bis(trimethylsilyl) ethanamideBis(trimethylsilyl) trifluoroacetamide 98+ gas chromatography

UNII-5T8NA426KZSCHEMBL50594bistrimethylsilyltrifluoroacetamidebis-trimethylsilyltrifluoroacetamidebistrimethylsilyl-trifluoroacetamidebistrimethylsilyltrifluoro- acetamideTrifluoroacetamide, 2TMS derivativeEINECS 244-242-7

Database identifiers

CAS: 21149-38-2
PubChem CID: 65279
DTXSID: DTXSID8066682
UNII: 5T8NA426KZ
EC Number: 244-242-7
Nikkaji: J226.151K

Properties

Computed structural properties

Topological polar surface area: 20.3 Å²
Hydrogen bond donors: 0
Hydrogen bond acceptors: 4
Rotatable bonds: 2
Heavy atoms: 15
Formal charge: 0
Complexity: 238

Experimental & physicochemical properties

Chemical ClassesMetals -> Metalloid Compounds (Silicon)

SpringerMaterials Properties29Si nuclear magnetic resonance spectrum

Physical DescriptionClear colorless liquid; [MP Biomedicals MSDS]

Physicochemical properties

Melting point: 41 · 41-44 °C(lit.)
Boiling point: 87 · 87-90 °C4 mm Hg(lit.)
Density: 1.018 · 1.018±0.06 g/cm3(Predicted)
Flash point: 27 °F · 27 °F
storage temp.: 0 · 0-6°C
pka: -1.04 · -1.04±0.70(Predicted)
FDA UNII: 5 T8NA426KZ · 5T8NA426KZ
EPA Substance Registry System: 2 · Acetamide, 2,2,2-trifluoro-N,N-bis(trimethylsilyl)- (21149-38-2)
Hazard Codes: F,C
Risk Statements: 11 · 11-34
Safety Statements: 16 · 16-26-36/37/39-45
RIDADR: 2925 · UN 2925 4.1/PG 2
WGK Germany: 3 · 3
F: 3 · 3-10-21
TSCA: TSCA listed
HazardClass: MOISTURE SENSITIVE, FLAMMABLE

Safety & regulation

Hazard information

Regulatory Information · 2 items

Chemical: Acetamide, 2,2,2-trifluoro-N,N-bis(trimethylsilyl)-

Acetamide, 2,2,2-trifluoro-N,N-bis(trimethylsilyl)-: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummarySee N,N-Diethyl-1,1,1-trimethylsilylamine.

Safety data

F: 3-10-21
wgk: 3
tsca: TSCA listed
ridadr: UN 2925 4.1/PG 2
risk_code: 11-34
hazard_code: F,C
safety_code: 16-26-36/37/39-45
hazard_class: MOISTURE SENSITIVE, FLAMMABLE

Chemistry & industry

Pharmacology

MeSH Pharmacological Classification · 1 item

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)