Basic information
- CAS
34645-84-6- Standard SMILES
O=C(O)Cc1ccccc1Oc1ccc(Cl)cc1Cl- InChIKey
IDKAXRLETRCXKS-UHFFFAOYSA-N- Molecular formula
- C14H10Cl2O3
- Average molar mass
- 297.1 g/mol
- Monoisotopic mass
- 296.0006996
Overview
Fenclofenac is an aromatic ether.
Names & identifiers
- Preferred name
- Fenclofenac
- IUPAC
- 2-[2-(2,4-dichlorophenoxy)phenyl]acetic acid
- English name
- fenclofenac
- Molecular formula
- C14H10Cl2O3
- Molecular weight
- 297.136
Names & synonyms
Fenclofenac34645-84-6FenclofenacoRx 67408FenclofenacumDTXSID6048830R 67408(o-(2,4-Dichlorophenoxy)phenyl)acetic acidBenzeneacetic acid, 2-(2,4-dichlorophenoxy)-RX-67408Y01JW64D01R-67408
Show more names
[o-(2,4-Dichlorophenoxy)phenyl]acetic acid[2-(2,4-dichlorophenoxy)phenyl]acetic acid - [AC80138]
DTXCID90287562-(2,4-dichlorophenoxy)phenylacetic acidRefChem:598864252-126-2Flenac2-[2-(2,4-dichlorophenoxy)phenyl]acetic acid2-(2,4-Dichlorophenoxy)benzeneacetic acid(2-(2,4-Dichlorophenoxy)phenyl)acetic acid
Database identifiers
- CAS
34645-84-6- PubChem CID
- 65394
- DTXSID
DTXSID6048830- ChEMBL
CHEMBL15677- ChEBI
CHEBI:135254- UNII
- Y01JW64D01
- EC Number
- 252-126-2
- Nikkaji
- J19.453K
Properties
Computed structural properties
- XLogP
- 4.8
- Topological polar surface area
- 46.5 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 4
- Heavy atoms
- 19
- Formal charge
- 0
- Complexity
- 311
Experimental & physicochemical properties
LogP4.8
Physicochemical properties
- Melting point
- 135 ℃ · 135.0℃
- Boiling point
- 410.72 °C · 410.72°C (rough estimate)
- Density
- 1.3076 · 1.3076 (rough estimate)
- refractive index
- 1.5209 · 1.5209 (estimate)
- storage temp.
- -20 °C · Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.53 · pKa 4.53 (Uncertain)
- color
- Off-White to Light Brown
- Water Solubility
- 8.439 mg/L · 8.439mg/L(25 ºC)
- Stability
- Hygroscopic
- FDA UNII
- 1 JW64D01 · Y01JW64D01
- Toxicity
- 50 oral · LD50 oral in rat: 2280mg/kg
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Hazard information
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Safety data
- Toxicity
- LD50 oral in rat: 2280mg/kg
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Applications
UsesAnti-inflammatory.
UsesFenclofenac is used for the same indications as diclofenac.
UsesFenclofenac is a non-steroidal anti-inflammatory agent functioning as a protein-pump inhibitor.
Upstream & downstream products
Upstream raw materials
Suppliers12 total
艾吉析科技（上海）有限公司17717235263 · [email protected]
南京世洲生物科技有限公司025-025-85560043 17301488900 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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