Basic information
- CAS
37338-39-9- Standard SMILES
CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1.COc1ncnc(NS(=O)(=O)c2ccc(N)cc2)c1OC- InChIKey
LUBUTTBEBGYNJN-UHFFFAOYSA-N- Molecular formula
- C24H27ClN8O4S
- Average molar mass
- 559 g/mol
- Monoisotopic mass
- 558.1564502
Overview
Pyrimethamine-Sulfadoxine is a combination product containing pyrimethamine and sulfadoxine. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins. Sulfadoxine competitively antagonizes paraaminobenzoic acid (PABA), resulting in disruption of folic acid synthesis and ultimately DNA synthesis. Sulfadoxine acts synergistically with pyrimethamine. (NCI04)
Names & identifiers
- Preferred name
- Pyrimethamine; sulfadoxine
- IUPAC
- 4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide;5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine
- English name
- sulfadoxine-pyrimethamine
- Molecular formula
- C12H14N4O4S.C12H13ClN4
- Molecular weight
- 559.048
Names & synonyms
FansidarPyrimethamine-sulfadoxineNSC618943RefChem:58925Pyrimethamine SulfadoxinePyrimethamine; sulfadoxinesulfadoxine & pyrimethaminesulfadoxine + pyrimethamine37338-39-9fanasil - pyrimethamineSuldoxsulfadoxine-pyrimethamine
Show more names
Ro-6-4753Combination with sulfadoxine
4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide;5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diaminesulphadoxine-pyrimethamineFansidar (TN)Sulphadoxyne-pyrimethaminesulfadoxine / pyrimethaminePyrimethamine / sulfadoxineSulphadoxine / pyrimethaminePyrimethamine combination with sulfadoxine
Database identifiers
- CAS
37338-39-9- PubChem CID
- 65404
- DTXSID
DTXSID70190780- ChEMBL
CHEMBL3137690
Properties
Computed structural properties
- Topological polar surface area
- 203 Ų
- Hydrogen bond donors
- 4
- Hydrogen bond acceptors
- 12
- Rotatable bonds
- 7
- Heavy atoms
- 38
- Formal charge
- 0
- Complexity
- 662
Experimental & physicochemical properties
Human Drugs
Breast Feeding; Lactation; Anti-Infective Agents; Antiparasitic Agents; Antimalarials; Antiprotozoal Agents; Sulfonamides
FDA approved drugs -> Active ingredient
Antimalarial medicines > Medicines for chemoprevention
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Toxicology
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
Chemistry & industry
Pharmacology
ATC CodeP01BD51
Suppliers2 total
Bhumit Pharma Pvt. Ltd.—
CHEMICAL LAND21[email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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