CAS 502-97-6 Glycolide (HCID 65432)

Overview

ABH001 is under investigation in clinical trial NCT01749306 (A Study of the Efficacy and Safety of ABH001 in the Treatment of Patients With Epidermolysis Bullosa Who Have Wounds That Are Not Healing).

Names & identifiers

Preferred name: Glycolide
IUPAC: 1,4-dioxane-2,5-dione
English name: 1,4-Dioxane-2,5-dione
Molecular formula: C4H4O4
Molecular weight: 116.07

Names & synonyms

GlycolideGlycollidep-Dioxane-2,5-dioneUNII-YRZ676PGU6YRZ676PGU6EINECS 207-954-9NSC 403079NSC-403079RefChem:74901,4-Dioxane-2,5-dione502-97-6MFCD00081108

Show more names

GlycolidGLYCOLIDE A1,4-DIOXANE-2,3-DIOLL10014EGlycolide>GLYCOLIDE USPPURASORB(R) GGA Glycolide

1,4-Dioxan-2,5-dioneGlycolide S;Glycollide; Glycolide26202-08-42,5-dioxo-1,4-dioxaneGlycolide,99.9%Glycolide, >=99%SCHEMBL15066ABH001

Database identifiers

CAS: 502-97-6
PubChem CID: 65432
DTXSID: DTXSID8060115
UNII: YRZ676PGU6
EC Number: 207-954-9
Nikkaji: J2.602F

Properties

Computed structural properties

XLogP: -0.2
Topological polar surface area: 52.6 Å²
Hydrogen bond donors: 0
Hydrogen bond acceptors: 4
Rotatable bonds: 0
Heavy atoms: 8
Formal charge: 0
Complexity: 112

Experimental & physicochemical properties

SpringerMaterials PropertiesFusion temperature

Physical DescriptionLarge Crystals

Physicochemical properties

Melting point: 81 · 81-83°C
Boiling point: 130 °C · 130°C(lit.)
Density: 1.1315 · 1.1315 (rough estimate)
refractive index: 1.45 · 1.4500 (estimate)
storage temp.: -20 °C · -20°C
solubility: Dichloromethane (Slightly), DMSO (Slightly)
form: Solid
color: White to Off-White
Stability: Hygroscopic
Cosmetics Ingredients Functions: HUMECTANTSKIN CONDITIONING
InChI: InChI=1S/C4H4O4/c5-3-1-7-4(6)2-8-3/h1-2H2
InChIKey: RKDVKSZUMVYZHH-UHFFFAOYSA-N
SMILES: O1CC(=O)OCC1=O
CAS DataBase Reference: 502 · 502-97-6(CAS DataBase Reference)
FDA UNII: 676 PGU6 · YRZ676PGU6
NIST Chemistry Reference: 1 · 1,4-Dioxane-2,5-dione(502-97-6)
EPA Substance Registry System: 1 · 1,4-Dioxane-2,5-dione (502-97-6)
UNSPSC Code: 12162002 · 12162002
NACRES: 23 · NA.23
Symbol(GHS): 7 · GHS07
Signal word: Warning
Hazard statements: 302 · H302-H319
Precautionary statements: 264 · P264-P270-P280-P301+P312-P305+P351+P338-P337+P313
PPE: 95 · dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes: Xi,Xn
Risk Statements: 36 · 36/37/38-36-22
Safety Statements: 22 · 22-24/25-37/39-26
WGK Germany: 3 · 3
TSCA: TSCA listed
HS Code: 29322090 · 29322090
Storage Class: 11 · 11 - Combustible Solids
Hazard Classifications: 4 OralEye · Acute Tox. 4 OralEye Irrit. 2
REACH Registrations: Active

Safety & regulation

GHS classification

GHS Classification · 4 items

Warning

H302 (93.3%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P330, P337+P317, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 45 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory Information · 3 items

1,4-Dioxane-2,5-dione is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,4-Dioxane-2,5-dione are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Status: Active Update: 08-07-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/20813

Hazard Classes and CategoriesAcute Tox. 4 (93.3%)

Safety data

PPE: dust mask type N95 (US), Eyeshields, Gloves
wgk: 3
tsca: TSCA listed
hs_code: 29322090
risk_code: 36/37/38-36-22
Signal word: Warning
Symbol(GHS): GHS07
hazard_code: Xi,Xn
safety_code: 22-24/25-37/39-26
Storage Class: 11 - Combustible Solids
Hazard statements: H302-H319
REACH Registrations: Active
Hazard Classifications: Acute Tox. 4 OralEye Irrit. 2
Precautionary statements: P264-P270-P280-P301+P312-P305+P351+P338-P337+P313

Chemistry & industry

Uses & manufacturing

U.S. Production2020: 442,847 lb

Industry UsesMonomers

General Manufacturing Information · 2 items

Plastics Material and Resin Manufacturing

1,4-Dioxane-2,5-dione: ACTIVE

Applications · 2 items

Uses1,4-Dioxane-2,5-dione is used in the fabricating of artificial blood vessels.

General DescriptionGlycolide is a cyclic dimer of α-hydroxy acid that can be used in the formation of aliphatic polyester. It is synthesized by the dimerization of glycolic acid. It forms a low toxic synthetic biodegradable polymer that can be used in medical applications. It is majorly used in the formation of a highly crystalline poly(glycolide) by ring opening polymerization.