Basic information
- CAS
151-06-4- Standard SMILES
CC(C)(N)Cc1ccc(Cl)cc1.Cl- InChIKey
WEJDYJKJPUPMLH-UHFFFAOYSA-N- Molecular formula
- C10H15Cl2N
- Average molar mass
- 220.14 g/mol
- Monoisotopic mass
- 219.0581549
Overview
Chlorphentermine Hydrochloride is the hydrochloride salt form of chlorphentermine, a chlorinated analogue of phentermine, a sympathomimetic amine with central nervous system (CNS) stimulating and anorexic activity. Chlorphentermine acts by facilitating the release of catecholamines, especially noradrenaline and dopamine, from nerve terminals in the brain and also inhibits their uptake. The increase in synaptic concentrations of these catecholamines causes behavioral changes including an increase in motor activity, mental alertness and excitement, causes euphoria, and suppresses appetite.
Names & identifiers
- Preferred name
- Chlorphentermine Hydrochloride
- IUPAC
- 1-(4-chlorophenyl)-2-methylpropan-2-amine;hydrochloride
- English name
- chlorphentermine hydrochloride
- Molecular formula
- C10H14ClN.ClH
- Molecular weight
- 0
Names & synonyms
Chlorphentermine hydrochloride151-06-4Pre-SateLucofenChlorphentermine HClNSC-76098DTXSID1047815RL11HOJ7DMW 2426p-Chloro-alpha,alpha-dimethylphenethylamine hydrochlorideDTXCID3027792Benzeneethanamine, 4-chloro-alpha,alpha-dimethyl-, hydrochloride
Show more names
α,α-DiMeImidazo[2,1-b]oxazole,6-(5-fluorophenyl)-p-Chloro-α,α-diMethylphenethylaMine Hydrochloride4-Chloro-α,α-diMethylphenethylaMine Hydrochloride(4-Chlorophenyl)-2-Methylpropan-2-aMine Hydrochloride4-Chloro-a,a-diMethyl-benzeneethanaMine hydrochloride4-Chloro-α,α-diMethyl-1-benzeneethanaMine Hydrochloride
W-2426NSC76098RefChem:54809Hydrochloride, Chlorphentermine205-782-91-(4-chlorophenyl)-2-methylpropan-2-amine hydrochlorideDezopimonLucofene
Database identifiers
- CAS
151-06-4
Properties
Computed structural properties
- Topological polar surface area
- 26 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 1
- Rotatable bonds
- 2
- Heavy atoms
- 13
- Formal charge
- 0
- Complexity
- 137
Experimental & physicochemical properties
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Physicochemical properties
- Melting point
- 234 ℃ · 234℃
- solubility
- 2 O: · H2O: 2 mg/mL, clear
- form
- Solid
- color
- white to beige
- SMILES
- NC(C)(C)CC1=CC=C(C=C1)Cl.Cl
- FDA UNII
- 11 HOJ7DM · RL11HOJ7DM
- NACRES
- 21 · NA.21
- Symbol(GHS)
- 8 · GHS08,GHS06
- Signal word
- Danger
- Hazard statements
- 301 · H301-H361
- Precautionary statements
- 201 · P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501
- Toxicity
- 50 in · LD50 in mice (mg/kg): 270 orally; 267 s.c. (Ciborska)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P203, P264, P270, P280, P301+P316, P318, P321, P330, P405, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Hazard information
Regulatory InformationBenzeneethanamine, 4-chloro-.alpha.,.alpha.-dimethyl-, hydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Hazard Classes and CategoriesAcute Tox. 3 (100%)
Safety data
- Toxicity
- LD50 in mice (mg/kg): 270 orally; 267 s.c. (Ciborska)
- Signal word
- Danger
- Symbol(GHS)
- GHS08,GHS06
- Hazard statements
- H301-H361
- Precautionary statements
- P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
Applications
Useschlorphentermine hydrochloride is an anorectic agent. Chlorphentermine is the 4-chloro derivative of the better known appetite suppressant Phentermine (P318830). chlorphentermine hydrochloride is structurally related to amphetamine but is a relatively weak stimulant with little abuse potential.
Suppliers15 total
艾吉析科技（上海）有限公司17717235263 · [email protected]
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
凯试(上海)科技有限公司021-50135380 · [email protected]
赛纳斯特化学（欢迎点击联系）021-60343070
Chongqing jooe co., ltd+86-15223382610 · [email protected]
青岛海智微元生物科技有限公司18317699790 18317699790 · [email protected]
艾吉析科技（上海）有限公司17717235263 17717235263 · [email protected]
陕西缔都医药化工有限公司029-029-81120477 17792793610 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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