Basic information
- CAS
59333-90-3- Standard SMILES
CC(C)NCC(O)COc1ccccc1C1CCCCC1.Cl- InChIKey
ODWXZMXQBDEIBF-UHFFFAOYSA-N- Molecular formula
- C18H30ClNO2
- Average molar mass
- 327.9 g/mol
- Monoisotopic mass
- 327.1965069
Overview
Exaprolol Hydrochloride is the hydrochloride form of exaprolol, a lipophilic derivative of the adrenergic blocking agent propranolol with sympatholytic activity. Exaprolol competitively binds to and blocks beta-adrenergic receptors in the heart and vascular smooth muscle, thereby causing negative chronotropic and inotropic effects leading to a reduction in cardiac output.
Names & identifiers
- Preferred name
- Exaprolol Hydrochloride
- IUPAC
- 1-(2-cyclohexylphenoxy)-3-(propan-2-ylamino)propan-2-ol;hydrochloride
Names & synonyms
Exaprolol hydrochlorideExaprolol HCl59333-90-3M.G. 8823MG-8823FGT82HNC7LNSC-297939RefChem:139707Exaprolol hydrochloride [USAN]1-(2-cyclohexylphenoxy)-3-(propan-2-ylamino)propan-2-ol;hydrochlorideExaprolol hydrochloride (USAN)UNII-FGT82HNC7L
Show more names
VULM 111 hydrochloride1-Isopropylamino-3-(2-cyclohexylphenoxy)-2-propanol hydrochloride(+-)-1-(o-Cyclohexylphenoxy)-3-(isopropylamino)-2-propanol hydrochlorideSCHEMBL612844CHEMBL2106276DTXSID301350522NSC297939NSC 297939
Database identifiers
- CAS
59333-90-3- PubChem CID
- 65484
- DTXSID
DTXSID301350522- ChEMBL
CHEMBL2106276- UNII
- FGT82HNC7L
Properties
Computed structural properties
- Topological polar surface area
- 41.5 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 7
- Heavy atoms
- 22
- Formal charge
- 0
- Complexity
- 276
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Related reactions
0 records
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Compound notes
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