Basic information
- CAS
61477-94-9- Standard SMILES
C[C@@H]1CCC[C@H](C)N1CCCC(O)(c1ccccc1)c1ccccn1.Cl- InChIKey
HFIHPVIVQSWZBV-ROSXHPEZSA-N- Molecular formula
- C22H31ClN2O
- Average molar mass
- 374.9 g/mol
- Monoisotopic mass
- 374.2124913
Overview
See also: Pirmenol (has active moiety).
Names & identifiers
- Preferred name
- Pirmenol Hydrochloride
- IUPAC
- 4-[(2R,6S)-2,6-dimethylpiperidin-1-yl]-1-phenyl-1-pyridin-2-ylbutan-1-ol;hydrochloride
- English name
- Pirmenol hydrochloride
- Molecular formula
- C22H31ClN2O
- Molecular weight
- 374.95
Names & synonyms
pirmenol hydrochloride61477-94-9PirmavarPirmenol HClDTXSID6021169CI-845CL-845Pirmenol monohydrochlorideCL-845 HYDROCHLORIDERefChem:929351DTXCID701169JA79OMG4QT
Show more names
PimavarCcris 5234(à)-Pirmenol hydrochloridPirmenol hydrochloride(cis)Pirmenol hydrochloride, >97%
Pirmenol (hydrochloride)Pirmenol.HCl4-((2R,6S)-2,6-Dimethylpiperidin-1-yl)-1-phenyl-1-(pyridin-2-yl)butan-1-ol hydrochlorideCI 845Cl 8454-[(2R,6S)-2,6-dimethylpiperidin-1-yl]-1-phenyl-1-pyridin-2-ylbutan-1-ol;hydrochloride4-[(2R,6S)-2,6-dimethyl-1-piperidyl]-1-phenyl-1-pyridin-2-yl-butan-1-o l hydrochloriderel-4-((2R,6S)-2,6-Dimethylpiperidin-1-yl)-1-phenyl-1-(pyridin-2-yl)butan-1-ol hydrochloride
Database identifiers
- CAS
61477-94-9- PubChem CID
- 65501
- DTXSID
DTXSID6021169- ChEMBL
CHEMBL1204211
Properties
Computed structural properties
- Topological polar surface area
- 36.4 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 6
- Heavy atoms
- 26
- Formal charge
- 0
- Complexity
- 385
Physicochemical properties
- Melting point
- 171 · 171-172 °C
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- 28 mg/mL · DMSO : ≥ 28 mg/mL (74.68 mM)
- form
- Solid
- color
- White to yellow
- FDA UNII
- 79 OMG4QT · JA79OMG4QT
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319-H335
- Precautionary statements
- 261 · P261-P305+P351+P338
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P305+P351+P338
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Applications
DescriptionPirrnenol hydrochloride is a long-lasting Class la antiarrhythmic agent introduced in Japan in 1994. The spectrum of antiarrhythmic activity of pirmenol includes atrial and ventricular arrhythmias of diverse etiology. In clinical trials, pirmenol was found effective in the short- and mid-term treatment of chronic premature ventricular beats, with or without underlying heart disease. In patients with supraventricular tachycardia, a single oral dose of pirmenol was highly effective in suppressing induction of tachycardia with adequate hemodynamic tolerance. Since pirmenol is highly effective by both intravenous and oral routes, it enables immediate suppression, prevention, or termination of cardiac arrhythmias and facilitates the transition to oral prophylactic therapy.
UsesCardiac depressant (anti-arrhythmic).
Suppliers24 total
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
上海冬洋生物科技有限公司0512-13601744364 13601744364 · [email protected]
Hunan Jibang Biological Technology Co., LTD13776644403 · [email protected]
InvivoChem中国13549236410 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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