Basic information
- CAS
142234-85-3- Standard SMILES
CCc1c(C)c2cc3nc(cc4nc(cc5c(CC)c(C)c(cc1[nH]2)n5C)C(C)=C4CCC(=O)O)C(CCC(=O)O)=C3C- InChIKey
XODZICXILWCPBD-UHFFFAOYSA-N- Molecular formula
- C35H40N4O4
- Average molar mass
- 580.7 g/mol
- Monoisotopic mass
- 580.30495577
Names & identifiers
- Preferred name
- 21H,23H-porphine-2,18-dipropanoic acid, 8,13-diethyl-3,7,12,17,23-pentamethyl
- IUPAC
- 3-[18-(2-carboxyethyl)-7,12-diethyl-3,8,13,17,22-pentamethyl-23H-porphyrin-2-yl]propanoic acid
- English name
- N-Methyl mesoporphyrin IX
- Molecular formula
- C35H40N4O4
- Molecular weight
- 580.72
Names & synonyms
RefChem:48391321H,23H-porphine-2,18-dipropanoic acid, 8,13-diethyl-3,7,12,17,23-pentamethyl853-236-9N-methyl mesoporphyrin IX142234-85-3N-methylmesoporphyrinIXCHEMBL6174832SCHEMBL13325428SCHEMBL18428599SCHEMBL29418995DTXSID70349630MFCD00216786
Show more names
8,13-Diethyl-3,7,12,17,23-pentamethyl-21H,23H-porphine-2,18-dipropanoic acid3,3'-(8,13-Diethyl-3,7,12,17,23-pentamethylporphyrin-2,18-diyl)dipropionic acid3-[20-(2-carboxyethyl)-10,15-diethyl-5,9,14,19,22-pentamethyl-21,22,23,24-tetraazapentacyclo[16.2.1.13,?.1?,11.113,1?]tetracosa-1,3,5,7,9,11(23),12,14,16,18(21),19-undecaen-4-yl]propanoic acid
3-[18-(2-carboxyethyl)-7,12-diethyl-3,8,13,17,22-pentamethyl-23H-porphyrin-2-yl]propanoic acidAS-78868DA-66139FM160646HY-13382121H,23H-porphine-2,18-dipropanoic acid, 8,13-diethyl-3,7,12,17,23-pentamethyl-21H,23H-Porphine-2,18-dipropanoic acid, 8,13-diethyl-3,7,12,17,23-pentamethyl- (9CI)21H,23H-Porphine-2,18-dipropanoicacid, 8,13-diethyl-3,7,12,17,23-pentamethyl- (9CI)
Properties
Computed structural properties
- XLogP
- 4.6
- Topological polar surface area
- 121 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 8
- Heavy atoms
- 43
- Formal charge
- 0
- Complexity
- 979
Physicochemical properties
- Density
- 1.26 · 1.26±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · Store at -20°C
- solubility
- 20 mg/ml; · DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.17 mg/ml; DMSO: 15 mg/ml
- form
- A crystalline solid
- color
- Brown to black
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 315 · H315-H319-H335
- Precautionary statements
- 264 · P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Hazard information
Hazard Classes and CategoriesSkin Irrit. 2 (100%)
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H315-H319-H335
- Precautionary statements
- P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Chemistry & industry
Applications
UsesN-Methylmesoporphyrin IX (NMM), a widely used G-quadruplex DNA specific fluorescent binder, is an efficient probe for monitoring Aβ fibrillation. N-Methylmesoporphyrin IX is an in situ inhibitor and an ex situ monitor for Aβ amyloidogenesis both in vitro and in cells. N-Methylmesoporphyrin IX is sensitive to G-quadruplexes DNA but has no response to duplexes, triplexes and single-stranded forms DNA. N-Methylmesoporphyrin IX is nonfluorescent alone or in monomeric Aβ environments, but emits strong fluorescence through stacking with the Aβ assemblies[1].
Suppliers28 total
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
浙江珲达生物科技有限公司0571-89903022 18679456698 · [email protected]
广东云星生物技术有限公司0751-18902340975/189023400307 18902340307 · [email protected]
TargetMol 中国（陶术生物）400-821-0310 15002144251 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
成都安斯利生物医药有限公司028-85305008 02885305008 · [email protected]
江苏艾康生物医药研发有限公司025-66028182 17714375163 · [email protected]
南通全益生物科技有限公司0513-66337626 18051384581 · [email protected]
启源（广东）医药化工有限公司18026564465 · [email protected]
风咏生物（AbMole）
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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