Mosapramine dihydrochloride
Basic information
- CAS
98043-60-8- Standard SMILES
Cl.Cl.O=C1NC2CCCCN2C12CCN(CCCN1c3ccccc3CCc3ccc(Cl)cc31)CC2- InChIKey
CVCDAZZJQWLXHM-UHFFFAOYSA-N- Molecular formula
- C28H37Cl3N4O
- Average molar mass
- 552 g/mol
- Monoisotopic mass
- 550.203295
Overview
Mosapramine dihydrochloride is a racemate comprising equimolar amounts of (R)- and (S)-mosapramine dihydrochloride. It has a role as a dopaminergic antagonist and a second generation antipsychotic.
Names & identifiers
- Preferred name
- Mosapramine dihydrochloride
- IUPAC
- 1'-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]spiro[1,5,6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-3,4'-piperidine]-2-one;dihydrochloride
- English name
- Y 516
- Molecular formula
- C28H35ClN4O
- Molecular weight
- 0
Names & synonyms
Mosapramine dihydrochlorideCreminmosapramine hydrochloride6M1W6HZL1XRefChem:109002998043-60-8Y-516Mosapramine hydrochloride [JAN]Mosapramine hydrochloride (JAN)1'-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]spiro[1,5,6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-3,4'-piperidine]-2-one;dihydrochlorideY 516UNII-6M1W6HZL1X
Show more names
1'-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]spiro[1,5,6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-3,4'-piperidine]-2-one1'-[3-(3-Chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]hexahydro-spiro[imidazo[1,2-a]pyridine-3(2H),4'-piperidin]-2-one dihydrochlorideSpiro[imidazo[1,2-a]pyridine-3(2H),4'-piperidin]-2-one, 1'-[3-(3-chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]hexahydro-, dihydrochloride (9CI)
Mosapramine HClSPIRO(IMIDAZO(1,2-A)PYRIDINE-3(2H),4'-PIPERIDIN)-2-ONE, 1'-(3-(3-CHLORO-10,11-DIHYDRO-5H-DIBENZ(B,F)AZEPIN-5-YL)PROPYL)HEXAHYDRO-, HYDROCHLORIDE (1:2)Clospipramine hydrochlorideSCHEMBL968109orb1696020CHEBI:31866DTXSID30913492GLXC-20327
Properties
Computed structural properties
- Topological polar surface area
- 38.8 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 4
- Heavy atoms
- 36
- Formal charge
- 0
- Complexity
- 725
Physicochemical properties
- Melting point
- 271 ° · 271°
- FDA UNII
- 6 M1W6HZL1X · 6M1W6HZL1X
- Toxicity
- 50 in · LD50 in male and female mice (mg/kg): 1008, 1293 orally; 74, 116 i.p.; 1147, 1264 s.c. (Horizoe)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Toxicity
- LD50 in male and female mice (mg/kg): 1008, 1293 orally; 74, 116 i.p.; 1147, 1264 s.c. (Horizoe)
Chemistry & industry
Applications
DescriptionClospipramine hydrochloride is a metabolite of clocapramine reportedly useful in the treatment of schizophrenia. In schizophrenic patients, its clinical efficacy and overall safety rating were not significantly different from clocapramine. However, at a lower dosage, clospipramine hydrochloride was more effective than clocapramine.
Additional notes
DefinitionChEBI: Mosapramine dihydrochloride is a racemate. It has a role as a dopaminergic antagonist and a second generation antipsychotic.
Related reactions
0 records
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Compound notes
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