Basic information
- CAS
63516-07-4- Standard SMILES
C[N+]1(CCF)[C@@H]2CC[C@H]1CC(OC(=O)C(O)(c1ccccc1)c1ccccc1)C2.[Br-]- InChIKey
FNUZASGZEHGWQM-RJRMRWARSA-M- Molecular formula
- C24H29BrFNO3
- Average molar mass
- 478.4 g/mol
- Monoisotopic mass
- 477.13148
Overview
Flutropium bromide is the organic bromide salt of flutropium. It is used in Japan for the treatment asthma and chronic obstructive pulmonary disease. It has a role as a muscarinic antagonist, an anti-asthmatic drug and an antispasmodic drug. It contains a flutropium.
Names & identifiers
- Preferred name
- Flutropium bromide
- IUPAC
- [(1S,5R)-8-(2-fluoroethyl)-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2,2-diphenylacetate bromide
- English name
- Flutropium bromide
- Molecular formula
- C24H29FNO3.Br
- Molecular weight
- 478.39
Names & synonyms
flutropium bromide63516-07-4Bronchospasmolytic agent 1Bromuro de flutropioBromure de flutropiumFlutropii bromidumFlutropium (bromide)Ba 598 BRDTXSID304865563516-10-9K3V6HB0M57DTXCID5032365
Show more names
Ba 598FlubronBa 598BrFlutropiumFlutropiumbromidFlutropium bromide USP/EP/BPTIANFU-CHEM_Flutropium Bromide Hydrate 63516-07-4[8-(2-Fluoroethyl)-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2,2-diphenylacetate bromide(1R,5S,8-syn)-8-Methyl-8-(2-fluoroethyl)-3α-[[diphenyl(hydroxy)acetyl]oxy]-8-azoniabicyclo[3.2.1]octane
FLUTROPIUM BROMIDE [JAN]Ba 598Br; Flubron[(1S,5R)-8-(2-fluoroethyl)-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2,2-diphenylacetate;bromideCAS-63516-07-4Flutropii bromidum [Latin]UNII-K3V6HB0M57Flutropium bromide [INN:JAN]Bromure de flutropium [French]
Database identifiers
Properties
Computed structural properties
- Topological polar surface area
- 46.5 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 7
- Heavy atoms
- 30
- Formal charge
- 0
- Complexity
- 538
Experimental & physicochemical properties
DrugsPharmaceuticals -> Respiratory system -> Nasal preparations
Physicochemical properties
- Melting point
- 192 · 192-193° (dec); mp 198-199° (dec)
- FDA UNII
- 3 V6HB0M57 · K3V6HB0M57
- Toxicity
- 50 in · LD50 in male, female mice, male, female rats (mg/kg): 12.5, 11.0, 16.4, 18.4 i.v.; 760, 810, 830, 740 orally (Bauer, Fügner)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Toxicity
- LD50 in male, female mice, male, female rats (mg/kg): 12.5, 11.0, 16.4, 18.4 i.v.; 760, 810, 830, 740 orally (Bauer, Fügner)
Chemistry & industry
Applications
DescriptionFlutropium bromide is an antitussive useful in the treatment of allergic rhinitis and in the symptomatic relief of bronchial asthma and chronic bronchitis. Recent studies suggest that flutropium bromide may have potential as a long-acting alternative to P-sympathomimetics or the xanthines in the prophylaxis of obstructive airways disease.
UsesFlutropium bromide is atropine derivatives and parasympathetic nerve blockers. Their main function is to counteract acetylcholine, and they also have antihistamine effects. They are used for bronchial obstruction and rhinitis.
Upstream & downstream products
Upstream raw materials
Suppliers19 total
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
Protheragen-ING+86-15618352007 · [email protected]
宝鸡缔都医药化工有限公司029-81145305 17791533577 · [email protected]
武汉鹏胤药业有限公司13163333255 · [email protected]
Related reactions
0 records
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Compound notes
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