Basic information
- CAS
21730-16-5- Standard SMILES
CNC1Cc2ccccc2N(C)c2ccccc21- InChIKey
YXVZOBVWVRFPTE-UHFFFAOYSA-N- Molecular formula
- C16H18N2
- Average molar mass
- 238.33 g/mol
- Monoisotopic mass
- 238.14699858
Overview
Metapramine is a dibenzooxazepine.
Names & identifiers
- Preferred name
- Metapramine
- IUPAC
- N,11-dimethyl-5,6-dihydrobenzo[b][1]benzazepin-5-amine
- English name
- Metapramine
- Molecular formula
- C16H18N2
- Molecular weight
- 238.33
Names & synonyms
Metapramine21730-16-5MetapraminaMetapraminum303954M7YF10,11-Dihydro-5-methyl-10-(methylamino)-5H-dibenz(b,f)azepineDTXSID6086501119560-RPRefChem:156796DTXCID7081346715-methyl-10-methylamino-10,11-dihydrodibenzo(b,f)-azepineMetapramine [INN]
Show more names
RP 19560Metapramine USP/EP/BP10,11-Dihydro-5-Methyl-10-5H-Dibenz[b,f]azepine5-Methyl-10-MethylaMino-10,11-dihydrodibenzo[b,f]azepine10,11-Dihydro-N,5-diMethyl-5H-Dibenz[b,f]azepin-10-aMine5H-Dibenz[b,f]azepin-10-amine, 10,11-dihydro-N,5-dimethyl-10,11-Dihydro-5-methyl-10-(methylamino)-5H-dibenz[b,f]azepine
N,11-dimethyl-5,6-dihydrobenzo[b][1]benzazepin-5-amineMetapraminum [Latin]Metapramina [Spanish]Metapraminum [INN-Latin]Metapramina [INN-Spanish]10,11-Dihydro-N,5-dimethyl-5H-dibenz[b,f]azepin-10-amine; 5H-Dibenz[b,f]azepine, 10,11-dihydro-5-methyl-10-(methylamino)- (8CI); 10,11-Dihydro-N,5-dimethyl-5H-dibenz[b,f]azepin-10-amine; 5-Methyl-10-methylamino-10,11-dihydrodibenzo[b,f]azepine; Metapramine; RP 1956019560 RPMETAPRAMINE [MI]
Properties
Computed structural properties
- XLogP
- 3
- Topological polar surface area
- 15.3 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 1
- Heavy atoms
- 18
- Formal charge
- 0
- Complexity
- 278
Physicochemical properties
- Melting point
- 237 · 237-240 °C
- Boiling point
- 350.8 · 350.8±42.0 °C(Predicted)
- Density
- 1.12 · 1.12±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Oil
- pka
- 9.09 · 9.09±0.20(Predicted)
- color
- Colourless to Pale Yellow
- Stability
- Hygroscopic
- FDA UNII
- 303954 M7YF · 303954M7YF
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However, the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.
Applications
DescriptionMetapramine is an antidepressant with a pharmacological profile similar to the tricyclics and an apparent rapid clinical onset of action. Metapramine differs biochemically from the tricyclics in that it markedly enhances norepinephrine turnover with minimal inhibition of reuptake. Like the tricyclics, however, it does down regulate β-receptors.
UsesMetapramine is a tricyclic antidepressant derived from dibenzoazepine. Metapramine acts as a norepinephrine reuptake inhibitor without affecting the reuptake of serotonin or dopamine.
Upstream & downstream products
Upstream raw materials
Suppliers13 total
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
凯试(上海)科技有限公司021-50135380 · [email protected]
BOC Sciences1-631-485-4226; 16314854226 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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