Basic information
- CAS
21535-47-7- Standard SMILES
CN1CCN2c3ccccc3Cc3ccccc3C2C1.[Cl-].[H+]- InChIKey
YNPFMWCWRVTGKJ-UHFFFAOYSA-N- Molecular formula
- C18H21ClN2
- Average molar mass
- 300.8 g/mol
- Monoisotopic mass
- 300.1393264
Overview
Mianserin hydrochloride is the hydrochloride salt of mianserin, a tetracyclic compound with antidepressant effects. It has a role as a geroprotector. It contains a mianserin.
Names & identifiers
- Preferred name
- CID 657192
- IUPAC
- hydron;5-methyl-2,5-diazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(19),8,10,12,15,17-hexaene;chloride
- English name
- Mianserin hydrochloride
- Molecular formula
- C18H21ClN2
- Molecular weight
- 300.83
Names & synonyms
SCHEMBL340475AKOS026749945MIANSERIN HCLMianserin impurity 47gb94TolvinTolvontoluonLerivonathymilorggb94Lantanon
Database identifiers
- CAS
21535-47-7- PubChem CID
- 657192
- ChEBI
CHEBI:31843
Properties
Computed structural properties
- Topological polar surface area
- 6.5 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 0
- Heavy atoms
- 21
- Formal charge
- 0
- Complexity
- 342
Physicochemical properties
- Melting point
- 230 oC · >230oC (dec.)
- Flash point
- 9 ℃ · 9℃
- storage temp.
- 2 · 2-8°C
- solubility
- 2 O: · H2O: 3.4 mg/mL
- form
- Solid
- color
- Off-White to Pale Yellow
- Water Solubility
- Soluble in water, ethanol, methanol, and dimethylformamide.
- Merck
- 14 · 14,6172
- Major Application
- pharmaceuticalpharmaceutical small molecule
- InChI
- InChI=1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H
- InChIKey
- YNPFMWCWRVTGKJ-UHFFFAOYSA-N
- SMILES
- N12CCN(C)CC1C1=CC=CC=C1CC1C=CC=CC2=1.Cl
- CAS DataBase Reference
- 21535 · 21535-47-7(CAS DataBase Reference)
- FDA UNII
- 2 X03TN217S · 2X03TN217S
- UNSPSC Code
- 41116107 · 41116107
- NACRES
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
- rtecs
- HP8780000
- ridadr
- 3249
- hs_code
- 2933.59.8000
- Toxicity
- LD50 in male, female mice (mg/kg): 365, 390 orally; 32.5, 31.0 i.v. (van Riezen)
- risk_code
- 22-39/23/24/25-23/24/25-11
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xn,Xi,T,F
- safety_code
- 7-16-36/37-45
- hazard_class
- 6.1(b)
- Storage Class
- 11 - Combustible Solids
- packing_group
- III
- Hazard statements
- H302
- Hazard Classifications
- Acute Tox. 4 Oral
- Precautionary statements
- P301+P312+P330
Chemistry & industry
Applications
UsesMianserin hydrochloride is a tetracyclic antidepressant with an EEG and clinical activity profile similar to amitriptyline. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
UsesMianserin hydrochloride is used as an antidepressant, antagonist, inverse agonist at 5-HT2 serotonin receptors, also blocks the H1 histamine receptor and the α2 adrenoceptor.
Upstream & downstream products
Upstream raw materials
Suppliers100 total
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
盐城通铭生物科技有限公司15195160625 · [email protected]
艾吉析科技（上海）有限公司
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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