Basic information
- CAS
541-22-0- Standard SMILES
C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C.[Br-]- InChIKey
UWAHZUFNAYDOTG-UHFFFAOYSA-M- Molecular formula
- C16H38BrN2+
- Average molar mass
- 338.39 g/mol
- Monoisotopic mass
- 337.22184
Names & identifiers
- Preferred name
- Syncurine
- IUPAC
- trimethyl-[10-(trimethylazaniumyl)decyl]azanium bromide
- English name
- DECAMETHONIUM BROMIDE
- Molecular formula
- C16H38Br2N2
- Molecular weight
- 418.29
Names & synonyms
MLS000028380DecacuranSyncurineSMR000058590C 10NSC272681, N,N,N,N',N',N'-hexamethyl-, monobromideWLN: 1K1&1&10K1&1&1 &E 2Opera_ID_473MLS001077302HMS2234B15HMS3370F14
Show more names
dekamethoniumbromidDECAMETHONIUM BROMIDEdecamethoniumdibromideDecamethonium Bromide >Decamethonium bromide ,98%Decamethonium Bromide, ≥ 98.0%DECAMETHONIUM BROMIDE USP/EP/BPDecamethonium bromide, 10 mM in DMSO
Pharmakon1600-01505991NSC23004NSC-27268NSC759300NSC-759300NCGC00180925-01
Database identifiers
- CAS
541-22-0- PubChem CID
- 657264
Properties
Computed structural properties
- Topological polar surface area
- 0 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 1
- Rotatable bonds
- 11
- Heavy atoms
- 19
- Formal charge
- 1
- Complexity
- 164
Physicochemical properties
- Melting point
- 263 · 263-267 °C(lit.)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- 2 mg/ml; · DMF: 2 mg/ml; DMSO: 16 mg/ml; Ethanol: 33 mg/ml; PBS (pH 7.2): 5 mg/ml
- form
- crystalline
- color
- off-white
- Water Solubility
- almost transparency
- λmax
- 240 nm · λ: 240 nm Amax: 0.04λ: 250 nm Amax: 0.03λ: 260 nm Amax: 0.02λ: 500 nm Amax: 0.02
- Merck
- 14 · 14,2847
- BRN
- 3728288 · 3728288
- Stability
- Stable. Incompatible with strong oxidizing agents.
- InChI
- 1S/C16H38N2.2BrH/c1-17(2,3)15-13-11-9-7-8-10-12-14-16-18(4,5)6;;/h7-16H2,1-6H3;2*1H/q+2;;/p-2
- InChIKey
- HLXQFVXURMXRPU-UHFFFAOYSA-L
- SMILES
- [Br-].[Br-].C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C
- CAS DataBase Reference
- 541 · 541-22-0(CAS DataBase Reference)
- FDA UNII
- 55 C6RK944K · 55C6RK944K
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- F
- 3-10
- PPE
- Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- BP5950000
- ridadr
- UN 2811 6.1/PG 3
- hs_code
- 2923.90.0100
- Toxicity
- LD50 oral in mouse: 190mg/kg
- risk_code
- 25-36/37/38
- Signal word
- Danger
- Symbol(GHS)
- GHS06
- hazard_code
- T
- safety_code
- 26-45
- hazard_class
- 6.1(b)
- Storage Class
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- packing_group
- III
- Hazard statements
- H301-H315-H319-H335
- Hazard Classifications
- Acute Tox. 3 OralEye Irrit. 2Skin Irrit. 2STOT SE 3
- Precautionary statements
- P261-P301+P310-P305+P351+P338
Chemistry & industry
Applications
DescriptionDecamethonium is a depolarizing neuromuscular blocking agent. It is a partial agonist of muscle-type nicotinic acetylcholine receptors (nAChRs). Decamethonium activates α1β1-containing adult mouse muscle-type nAChRs expressed in X. laevis oocytes with an EC50 value of 40 μM using voltage clamp electrophysiology. It is also a nondepolarizing antagonist of neuronal-type nAChRs, inhibiting mouse α7-, α3β2-, α3β4-, and α4β2-containing receptors with IC50 values of 7.4, 405, 28, and 59 μM, respectively. Decamethonoium is a competitive antagonist of α4β2-containing nAChRs expressed in SH-EP1 cells (IC50 = 52 μM for the human receptor). It also inhibits electric eel acetylcholinesterase (AChE) and blocks electrically-evoked tibialis muscle twitches in anesthetized cats with ED95 values of 35 and 70 μg/kg for cats under chloralose and ether anesthesia, respectively. Formulations containing decamethonium have been used to induce paralysis during anesthesia.
Usesantipsychotic
General DescriptionCrystals derived from methanol and acetone.
Suppliers73 total
陕西凯尔凯医药科技有限公司029-2148545164 17392779578 · [email protected]
国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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