Basic information
- CAS
19237-84-4- Standard SMILES
COc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OC.[Cl-].[H+]- InChIKey
WFXFYZULCQKPIP-UHFFFAOYSA-N- Molecular formula
- C19H22ClN5O4
- Average molar mass
- 419.9 g/mol
- Monoisotopic mass
- 419.1360319
Overview
Prazosin hydrochloride is a hydrochloride. It contains a prazosin.
Names & identifiers
- Preferred name
- [4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone;hydron;chloride
- IUPAC
- [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone;hydron;chloride
- English name
- Prazosin hydrochloride
- Molecular formula
- C19H22ClN5O4
- Molecular weight
- 419.86
Names & synonyms
SCHEMBL41258AKOS026750015PRAZOSIN HCL(4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(furan-2-yl)methanone hydrochloridehypovasepratsiolsinetensVasoflexperipressAdversutenAlpress LPcp-12299-1
Database identifiers
- CAS
19237-84-4- PubChem CID
- 657274
- ChEBI
CHEBI:8365
Properties
Computed structural properties
- Topological polar surface area
- 107 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 9
- Rotatable bonds
- 4
- Heavy atoms
- 29
- Formal charge
- 0
- Complexity
- 544
Physicochemical properties
- Melting point
- 277 · 277 - 280 °C
- storage temp.
- 2 · 2-8°C
- solubility
- 2 O: · H2O: 1 mg/mL, clear, colorless
- form
- solid
- color
- white
- Water Solubility
- Soluble in dimethyl sulfoxide, ethanol, water, methanol.
- Merck
- 14 · 14,7717
- BRN
- 4303561 · 4303561
- InChI
- InChI=1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H
- InChIKey
- WFXFYZULCQKPIP-UHFFFAOYSA-N
- SMILES
- N1(C2=NC(N)=C3C(=N2)C=C(OC)C(OC)=C3)CCN(C(C2=CC=CO2)=O)CC1.[H]Cl
- CAS DataBase Reference
- 19237 · 19237-84-4(CAS DataBase Reference)
- FDA UNII
- 0 Z7454B90 · X0Z7454B90
- UNSPSC Code
- 41116107 · 41116107
- NACRES
- 77 · NA.77
- Symbol(GHS)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- F
- 10
- PPE
- dust mask type N95 (US), Eyeshields, Gloves
- wgk
- 3
- rtecs
- VA1350000
- ridadr
- 3249
- hs_code
- 2934990002
- Toxicity
- dog,LD50,oral,> 700mg/kg (700mg/kg),GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDSKIDNEY, URETER, AND BLADDER: OTHER CHANGES GASTROINTESTINAL: NAUSEA OR VOMITING,Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 39, 1979.
- risk_code
- 22-36/37/38-62
- Signal word
- Warning
- Symbol(GHS)
- GHS07,GHS08
- hazard_code
- Xn
- safety_code
- 28-36
- hazard_class
- 6.1(b)
- Storage Class
- 11 - Combustible Solids
- packing_group
- III
- target organs
- Central nervous system
- Hazard statements
- H302-H315-H319-H335-H361
- Hazard Classifications
- Repr. 2STOT RE 2STOT SE 3
- Precautionary statements
- P201-P301+P312+P330-P302+P352-P305+P351+P338-P308+P313
- Hazardous Substances Data
- 19237-84-4(Hazardous Substances Data)
Chemistry & industry
Applications
UsesPrazosin Hydrochloride (Terazosin EP Impurity K) is an antihypertensive. α1-Adrenergic blocker.
UsesPrazosin hydrochloride has been used:to block the α1adrenergic receptors that mediate sympathetic vasoconstriction in miceas an α1-adrenoceptor blocker,administered intragastrically in ratsas a vasodilator,administered together with inuslin into the left ventricle of mice for the assessment of its effects on renal functions
General DescriptionThe antihypertensive effectsof prazosin hydrochloride, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)piperazine monohydrochloride(Minipress), are caused by peripheral vasodilation as a resultof its blockade of 1-adrenergic receptors. In ligand-bindingstudies, prazosin hydrochloride has 5,000-fold greater affinityfor α1-receptors than for some α2-adrenergic receptors.
Upstream & downstream products
Upstream raw materials
Suppliers100 total
国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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