Basic information
- CAS
34183-22-7- Standard SMILES
CCCNCC(O)COc1ccccc1C(=O)CCc1ccccc1.[Cl-].[H+]- InChIKey
XWIHRGFIPXWGEF-UHFFFAOYSA-N- Molecular formula
- C21H28ClNO3
- Average molar mass
- 377.9 g/mol
- Monoisotopic mass
- 377.1757714
Overview
See also: Propafenone Hydrochloride (preferred); Propafenone (has active moiety).
Names & identifiers
- Preferred name
- CID 657387
- IUPAC
- hydron;1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one;chloride
- English name
- Propafenone Hydrochloride
- Molecular formula
- C21H28ClNO3
- Molecular weight
- 377.9
Names & synonyms
SCHEMBL1651012AKOS026749966PROPAFENONE HCLPrononRythmolrytmonormSA-79 (hydrochloride)1-Propanone, 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-, hydrochloride (9CI)sa79wz884RopafulSobiral
Database identifiers
- CAS
34183-22-7- PubChem CID
- 657387
Properties
Computed structural properties
- Topological polar surface area
- 58.6 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 11
- Heavy atoms
- 26
- Formal charge
- 0
- Complexity
- 368
Physicochemical properties
- Melting point
- 165 · 165-1670C
- storage temp.
- 2 · 2-8°C
- solubility
- Slightly soluble in cold water, soluble in methanol and in hot water, practically insoluble in ethanol (96 per cent).
- form
- Solid
- color
- White to Off-White
- λmax
- 303 nm · 303nm(MeOH)(lit.)
- Merck
- 14 · 14,7794
- Major Application
- clinical testing
- InChI
- InChI=1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H
- InChIKey
- XWIHRGFIPXWGEF-UHFFFAOYSA-N
- SMILES
- C1(=CC=CC=C1C(=O)CCC1C=CC=CC=1)OCC(O)CNCCC.Cl
- CAS DataBase Reference
- 34183 · 34183-22-7(CAS DataBase Reference)
- FDA UNII
- 33 XCH0HOCD · 33XCH0HOCD
- UNSPSC Code
- 41116107 · 41116107
- NACRES
- 24 · NA.24
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
- rtecs
- UH2833000
- hs_code
- 2922504500
- Toxicity
- LD50 in rats (mg/kg): 18.8 i.v.; 700 orally (Hapke, Prigge)
- risk_code
- 46-22
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- T,Xn
- safety_code
- 53-36/37/39-45
- Storage Class
- 3 - Flammable liquids
- target organs
- Eyes
- Hazard statements
- H302
- Hazard Classifications
- Acute Tox. 3 DermalAcute Tox. 3 InhalationAcute Tox. 3 OralFlam. Liq. 2STOT SE 1
- Precautionary statements
- P301+P312+P330
Chemistry & industry
Applications
DescriptionPropafenone hydrochloride is a class I anti-arrhythmic agent with basic local anaesthetic and membrane-stabilizing properties. Some P-adrenergic blocking action has also been described. Propafenone decreases the depolarization velocity and slows conduction in the His-Purkinje system with resultant increase in the PR interval and the QRS complex. Propafenone is used in the treatment of paroxysmal supraventricular tachycardias and ventricular arrhythmias.Propafenone should not be used in uncontrolled cardiac failure, severe obstructive pulmonary disease or marked hypotension. Propafenone may worsen myasthenia gravis.
UsesPropafenone hydrochloride is a class IC antiarrhythmic agent used for the management of severe ventricular and supraventricular arrhythmias. It has beta-blocking and weak calcium channel blocking properties, as well as some negative inotropic activity. Propafenone is in a class of medications called antiarrhythmics. It works by acting on the heart muscle to improve the heart's rhythm.
UsesSodium channel blocker. Antiarrhythmic (class IC)
Upstream & downstream products
Upstream raw materials
Suppliers100 total
国药集团化学试剂有限公司86-21-63210123 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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