Basic information
- CAS
90697-57-7- Standard SMILES
CC1CC(=O)NN=C1c1cc(-n2ccnc2)cs1- InChIKey
NPFVRBCDMFKOPY-UHFFFAOYSA-N- Molecular formula
- C12H12N4OS
- Average molar mass
- 260.32 g/mol
- Monoisotopic mass
- 260.07318219
Overview
structure given in first source
Names & identifiers
- Preferred name
- Motapizone
- IUPAC
- 3-(4-imidazol-1-ylthiophen-2-yl)-4-methyl-4,5-dihydro-1H-pyridazin-6-one
- English name
- Motapizone
- Molecular formula
- C12H12N4OS
- Molecular weight
- 260.31
Names & synonyms
Motapizone90697-57-7MotapizonMotapizonaMotapizonumC4A61P8A37NAT-05-2394,5-dihydro-6-(4-(1H-imidazol-1-yl)-2-thienyl)-5-methyl-3(2H)-pyridazinoneRefChem:159828Motapizone [INN]NAT 05-2393-(4-imidazol-1-ylthiophen-2-yl)-4-methyl-4,5-dihydro-1H-pyridazin-6-one
Show more names
4,5-Dihydro-6-[4-(1H-imidazol-1-yl)-2-thienyl]-5-methylpyridazin-3(2H)-one3(2H)-Pyridazinone, 4,5-dihydro-6-[4-(1H-imidazol-1-yl)-2-thienyl]-5-methyl-
6-[4-(1H-imidazol-1-yl)thiophen-2-yl]-5-methyl-2,3,4,5-tetrahydropyridazin-3-one(+-)-4,5-Dihydro-6-(4-imidazol-1-yl-2-thienyl)-5-methyl-3(2H)-pyridazinoneMotapizonum [Latin]Motapizona [Spanish]UNII-C4A61P8A37SCHEMBL385669orb1983549CHEMBL2104670
Database identifiers
- CAS
90697-57-7- PubChem CID
- 65819
- DTXSID
DTXSID30869061- ChEMBL
CHEMBL2104670- UNII
Properties
Computed structural properties
- XLogP
- 1.3
- Topological polar surface area
- 87.5 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 2
- Heavy atoms
- 18
- Formal charge
- 0
- Complexity
- 373
Physicochemical properties
- form
- Solid
- color
- Light yellow to yellow
- FDA UNII
- 4 A61P8A37 · C4A61P8A37
Chemistry & industry
Applications
UsesMotapizone (NAT 05-239) is a selective PDE3 inhibitor. Motapizone moderately inhibits cytokine release in lipopolysaccharide (LPS)-induced alveolar macrophages. Motapizone also inhibits human platelet aggregation by increasing intracellular cAMP[1][2].
Suppliers4 total
2A PharmaChem USA[email protected]
Leancare Ltd.[email protected]
Lanospharma Laboratories Co.,Ltd13440048448 · [email protected]
3B Scientific Corporation[email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…