Flomoxef

HCID 65864CAS 99665-00-6

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Basic information

Standard SMILES
CO[C@@]1(NC(=O)CSC(F)F)C(=O)N2C(C(=O)O)=C(CSc3nnnn3CCO)CO[C@@H]21
InChIKey
UHRBTBZOWWGKMK-DOMZBBRYSA-N
Molecular formula
C15H18F2N6O7S2
Average molar mass
496.474 g/mol
Monoisotopic mass
496.06464536

Names & identifiers

Preferred name
Flomoxef
IUPAC
(6R,7R)-7-{2-[(Difluoromethyl)sulfanyl]acetamido}-3-({[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]sulfanyl}methyl)-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
English name
Flomoxef
Molecular formula
C15H18F2N6O7S2
Molecular weight
496.47

Names & synonyms

FMOXFlumarinFLOMOXEFFLOMOEXFFlomoxef AcidFlomoxef MonomerFlomoxef USP/EP/BPFlomoxef Acid(Sodium)8-Pyridinecarboxamide,N-phenyl-Flomoxef Sodium、Flumarin、Sodium Flomoxef

Database identifiers

CAS
99665-00-6
PubChem CID
65864
DTXSID
DTXSID5048845
ChEMBL
CHEMBL15413
ChEBI
CHEBI:135813
UNII
V9E5U5XF42
Nikkaji
J37.274I

Properties

Physicochemical properties

Melting point
82.5 · 82.5-87.5°
Density
1.85 · 1.85±0.1 g/cm3(Predicted)
storage temp.
-20 °C · Store at -20°C
solubility
soluble in DMSO, Methanol
form
Solid
pka
3.26 · 3.26±0.40(Predicted)

Chemistry & industry

Applications · 2 items

DescriptionFlomoxef sodium is a P-lactamase resistant oxacephalosporin. Its spectrum of activity is similar to that of cefazolin and moxalactam, but with better efficacy against Staphylococcus aureus and Bacteroides fragilis. Flomoxef is reported effective in the treatment of post-operative, urinary tract and abdominal cavity infections.

UsesFlomoxef is an oxacephem derived beta-lactam antibiotic that is particularly effective against gram-positive bacteria.

Upstream & downstream products

Suppliers50 total

北京华美互利生物化工010-56205725 · [email protected]
Hebei Chuanghai Biotechnology Co., Ltd+86-17732866630 · [email protected]
湖北威德利化学试剂有限公司181-6332-1995 18062128043 · [email protected]
咸宁深蓝生物医药研发有限公司18171815831 · [email protected]
Hebei Yanxi Chemical Co., Ltd.+86-17531190177 · [email protected]
Additional notes · 1 item

DefinitionChEBI: Flomoxef is a second-generation oxacephem antibiotic in which the oxazine ring is substituted at C-3 with a hydroxyethyl-substituted tetrazolylthiomethyl group and the azetidinone ring carries 7alpha-methoxy and 7beta-{2-[(difluoromethyl)thiomethyl]acetamido} substituents. It has a role as an antibacterial drug. It is a N-acyl-amino acid, an oxacephem and an organonitrogen heterocyclic antibiotic.

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