Lintopride
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Basic information
- CAS
107429-63-0- Standard SMILES
CCN1CCN=C1CNC(=O)c1cc(Cl)c(N)cc1OC- InChIKey
MJCKISCWHDATBN-UHFFFAOYSA-N- Molecular formula
- C14H19ClN4O2
- Average molar mass
- 310.78 g/mol
- Monoisotopic mass
- 310.1196536
Overview
Lintopride is a small molecule drug. The usage of the INN stem '-pride' in the name indicates that Lintopride is a sulpiride derivative and analogue. Lintopride has a monoisotopic molecular weight of 310.12 Da.
Names & identifiers
- Preferred name
- Lintopride
- IUPAC
- 4-amino-5-chloro-N-[(1-ethyl-4,5-dihydroimidazol-2-yl)methyl]-2-methoxybenzamide
- English name
- Lintopride
- Molecular formula
- C14H19ClN4O2
- Molecular weight
- 310.78
Names & synonyms
Lintopride107429-63-0LintopridaLintopridumC2R0GEU722DTXSID70148049ACEMMRefChem:153579DTXCID80705404-amino-5-chloro-N-((1-ethylimidazolin-2-yl)methyl)-2-methoxybenzamideLintopride [INN]4-amino-5-chloro-N-[(1-ethyl-4,5-dihydroimidazol-2-yl)methyl]-2-methoxybenzamide
Show more names
4-Amino-5-chloro-N-((1-ethyl-2-imidazolin-2-yl)methyl)-o-anisamideBenzamide, 4-amino-5-chloro-N-[(1-ethyl-4,5-dihydro-1H-imidazol-2-yl)methyl]-2-methoxy-Lintopridum [INN-Latin]Lintoprida [INN-Spanish]UNII-C2R0GEU7224-amino-5-chloro-n-[(1-ethyl-4,5-dihydro-1h-imidazol-2-yl)methyl]-2-methoxybenzamideSCHEMBL636567orb1707064
Database identifiers
- CAS
107429-63-0- PubChem CID
- 65900
- DTXSID
DTXSID70148049- ChEMBL
CHEMBL2106767- UNII
- C2R0GEU722
- Nikkaji
- J561.814B
Properties
Computed structural propertiesFilling in
- XLogP
- 0.7
- Topological polar surface area
- 80 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 5
- Heavy atoms
- 21
- Formal charge
- 0
- Complexity
- 404
Physicochemical properties
- Boiling point
- 494.1 · 494.1±45.0 °C(Predicted)
- Density
- 1.35 · 1.35±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 13.2 · 13.20±0.46(Predicted)
- color
- Light yellow to yellow
- FDA UNII
- 2 R0GEU722 · C2R0GEU722
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319-H335
- Precautionary statements
- 261 · P261-P305+P351+P338
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P305+P351+P338
Chemistry & industry
Applications
UsesLintopride, a benzamide, is a potent 5HT-4 antagonist with moderate 5HT-3 antagonist properties. Lintopride increases gastric emptying, stimulates antral and duodenal motility and accelerates intestinal transit in animal. Lintopride significantly increases the lower oesophageal sphincter (LOS) basal tone[1].
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Compound notes
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