Basic information
- CAS
132-18-3- Standard SMILES
CN1CCC(OC(c2ccccc2)c2ccccc2)CC1.Cl- InChIKey
LPRLDRXGWKXRMQ-UHFFFAOYSA-N- Molecular formula
- C19H24ClNO
- Average molar mass
- 317.9 g/mol
- Monoisotopic mass
- 317.1546421
Overview
See also: Diphenylpyraline (has active moiety).
Names & identifiers
- Preferred name
- Diphenylpyraline Hydrochloride
- IUPAC
- 4-benzhydryloxy-1-methylpiperidine;hydrochloride
- English name
- Diphenylpyraline Hydrochloride
- Molecular formula
- C19H24ClNO
- Molecular weight
- 317.85
Names & synonyms
Diphenylpyraline hydrochloride132-18-3Diphenylpyraline HClAllerzineHisprilLergobanBelfene hydrochlorideAerogastolAnginosanHistrylPiperidine, 4-(diphenylmethoxy)-1-methyl-, hydrochlorideDTXSID7047772
Show more names
4-Benzhydryloxy-1-methylpiperidine~Diphenylpyraline hydrochlorideLergobineHy-staminLABOTEST-BB LT00159897Diphenylpyraline hydrochlorid4-diphenylmethoxy-1-methylpiperidine4-(benzhydryloxy)-1-methylpiperidine4-(Diphenyl Methoxy)-1-piperidine HCl
1-Methylpiperidyl-4-benzhydrylether hydrochlorideNSC-61825G9FU7F1E874-(Diphenylmethoxy)-1-methylpiperidine hydrochloride1-Methyl-4-piperidyl benzhydryl ether hydrochlorideDTXCID7027752CHEBI:31508Histryl paed
Database identifiers
- CAS
132-18-3- PubChem CID
- 66063
- DTXSID
Properties
Computed structural properties
- Topological polar surface area
- 12.5 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 4
- Heavy atoms
- 22
- Formal charge
- 0
- Complexity
- 268
Experimental & physicochemical properties
Solubility>47.7 [ug/mL] (The mean of the results at pH 7.4)
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Collision Cross Section173.8 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physicochemical properties
- Melting point
- 203 · 203-205 °C(lit.)
- storage temp.
- 2 · under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- Merck
- 13 · 13,3363
- Stability
- Hygroscopic
- InChI
- InChI=1S/C19H23NO.ClH/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17;/h2-11,18-19H,12-15H2,1H3;1H
- InChIKey
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 41 reports by companies from 2 notifications to the ECHA C&L Inventory.
Hazard information
Regulatory InformationPiperidine, 4-(diphenylmethoxy)-1-methyl-, hydrochloride: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Piperidine, 4-(diphenylmethoxy)-1-methyl-, hydrochloride: Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Safety data
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- TM7823600
- ridadr
- 3249
- Toxicity
- mouse,LD50,intramuscular,64300ug/kg (64.3mg/kg),Drugs in Japan Vol. 6, Pg. 333, 1982.
- risk_code
- 20/21/22-36/37/38-22
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xn
- safety_code
- 26-36
- hazard_class
- 6.1(b)
- packing_group
Chemistry & industry
Uses & manufacturing
General Manufacturing InformationPiperidine, 4-(diphenylmethoxy)-1-methyl-, hydrochloride (1:1): INACTIVE
Applications
DescriptionDiphenylpyraline is an antihistamine drug with anticholinergic and sedative action. It is intended for symptomatic treatment of seasonal allergies and allergic reactions as well as an adjuvant drug in anaphylactic reaction therapy. Synonyms of this drug are arbid, timpil, histryl, hispril, and others.
UsesAntihistaminic;H1 antagonist
UsesDiphenylpyraline Hydrochloride is a salt of Diphenylpyraline (D492110), an H1 receptor antagonist (an antihistamine) and is commonly prescribed to treat allergic and vasomotor rhinitis. There is also some research being conducted on diphenylpyraline derivatives to determine their antimycobacterial and antifungal activity.
General DescriptionDiphenylpyr alinehydrochloride, 4-(diphenylmethoxy)-1-methylpiperidinehydrochloride (Hispril, Diafen) is a white or slightly offwhitecrystalline powder that is soluble in water or alcohol.Diphenylpyraline is structurally related to diphenhydraminewith the aminoalkyl side chain incorporated in a piperidinering. It is a potent antihistaminic, and the usual dose is 2 mg3 or 4 times daily.
Upstream & downstream products
Upstream raw materials
Suppliers58 total
艾吉析科技（上海）有限公司
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…