Basic information
- CAS
1098-60-8- Standard SMILES
CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21.Cl- InChIKey
FTNWXGFYRHWUKG-UHFFFAOYSA-N- Molecular formula
- C18H20ClF3N2S
- Average molar mass
- 388.9 g/mol
- Monoisotopic mass
- 388.098782
Names & identifiers
- Preferred name
- 10H-Phenothiazine-10-propanamine, N,N-dimethyl-2-(trifluoromethyl)-, monohydrochloride
- IUPAC
- N,N-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine;hydrochloride
- English name
- Triflupromazine hydrochloride
- Molecular formula
- C18H20ClF3N2S
- Molecular weight
- 388.88
Names & synonyms
Triflupromazine hydrochloride1098-60-8Triflupromazine HClFluopromazine monohydrochlorideTriflupromazine monohydrochlorideTrifluopromazine hydrochlorideDTXSID8045804NSC-14959NSC-174739E75N4A5HM10H-Phenothiazine-10-propanamine, N,N-dimethyl-2-(trifluoromethyl)-, monohydrochlorideMC-4703
Show more names
NeoprinFlumazinFluorofentriflupromazineHClLABOTEST-BB LT00772332TRIFLUPROMAZINE HCL IP/USPFluopromazine hydrochloridetrifluopromazinehydrochlorideTriupromazine Hydrochloride (200 mg)
DTXCID602580410-(3-Dimethylaminopropyl)-2-(trifluoromethyl)phenothiazine hydrochloride10-(3-(Dimethylamino)propyl)-2-(trifluoromethyl)phenothiazine monohydrochlorideCHEBI:971210-[3-(Dimethylamino)propyl]-2-(trifluoromethyl)phenothiazine monohydrochlorideRefChem:1057302Vetame Injectable, Vetame Tablets214-149-6
Properties
Computed structural properties
- Topological polar surface area
- 31.8 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 4
- Heavy atoms
- 25
- Formal charge
- 0
- Complexity
- 416
Experimental & physicochemical properties
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Animal DrugsFDA approved animal drugs -> Active ingredient
Collision Cross Section175.6 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physicochemical properties
- Melting point
- 174 to · 174.0 to 179.0 °C
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- Water Solubility
- Soluble in water
- solubility
- 5 mg/mL; · DMF: 5mg/mL; DMSO: 3mg/mL; Ethanol: 5mg/mL; Ethanol:PBS (pH 7.2) (1:10): 0.09mg/mL
- color
- White to Light yellow
- λmax
- 305 nm · 305nm(H2O)(lit.)
- Merck
- 14 · 14,9685
- BRN
- 3801519 · 3801519
- Stability
- Hygroscopic
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P261, P264, P270, P271, P280, P301+P316, P302+P352, P304+P340, P317, P321, P330, P362+P364, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information10H-Phenothiazine-10-propanamine, N,N-dimethyl-2-(trifluoromethyl)-, monohydrochloride: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - 10H-Phenothiazine-10-propanamine, N,N-dimethyl-2-(trifluoromethyl)-, monohydrochloride: Human health tier I assessment
Hazard Classes and CategoriesAcute Tox. 3 (100%)
Safety data
- wgk
- 3
- rtecs
- SO8925000
- ridadr
- UN 2811 6.1/PG 3
- hs_code
- 2934302300
- risk_code
- 20/21/22
- Signal word
- Danger
- Symbol(GHS)
- GHS06
- hazard_code
- Xn
- safety_code
- 36
- hazard_class
- 6.1
Chemistry & industry
Applications
DescriptionTriflupromazine is a phenothiazine with diverse biological activities. It binds to muscarinic receptors in isolated rat corpus striatum (IC50 = 100 μM in a radioligand binding assay). Triflupromazine inhibits serotonin (5-HT) uptake by isolated rat brainstem synaptosomes (IC50 = 0.8 μM). It inhibits T. cruzi infection in mouse peritoneal macrophages when used at a concentration of 12.5 μM. Triflupromazine is active against S. aureus, shigellae, and vibrios (MICs = 2-100 μg/ml) in vitro and is protective against S. typhimurium infection in mice when administered at a dose of 30 μg per animal. Formulations containing triflupromazine were previously used as antipsychotics.
Usesanalgesic, antiinflammatory, antipyretic, COX-II inhibitor
General DescriptionTriflupromazinehydrochloride, 10-[3-(dimethylamino)propyl]-2-(trifluoromethyl)phenothiazine monohydrochloride (Vesprin), has agreater milligram potency as an antipsychotic, higher EPS,but lower sedative and hypotensive effects than chlorpromazine.The 2-CF3 versus the 2-Cl is associated with thesechanges. Overall, the drug has uses analogous to those ofchlorpromazine.
Upstream & downstream products
Upstream raw materials
Suppliers56 total
国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
艾吉析科技（上海）有限公司
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…