N-Ethyl-p-toluenesulfonamide

HCID 6637

Basic information

CAS
1321-54-6
Standard SMILES
CCNS(=O)(=O)c1ccc(C)cc1
InChIKey
OHPZPBNDOVQJMH-UHFFFAOYSA-N
Molecular formula
C9H13NO2S
Average molar mass
199.27 g/mol
Monoisotopic mass
199.06669966

Overview

Platelets (from dilute alcohol or ligroin) or off-white solid. (NTP, 1992)

Names & identifiers

Preferred name
N-Ethyl-p-toluenesulfonamide
IUPAC
N-ethyl-4-methylbenzenesulfonamide
English name
Ethyl-p-toluenesulfonamide
Molecular formula
C9H13NO2S
Molecular weight
199.273

Names & synonyms

N-ETHYL-P-TOLUENESULFONAMIDEN-Ethyl-4-methylbenzenesulfonamideN-Ethyl-p-tolylsulfonamideBenzenesulfonamide, N-ethyl-4-methyl-N-Ethyl-4-toluenesulfonamideEthyl tosylamidep-Tolueneethylsulfonamideethyl-p-toluenesulfonamideN-Ethyltoluene-4-sulphonamideNSC 68803DTXSID5025310CCRIS 6037
Show more names
N-Ethylp-toluene Sulfonamide(N-PTSA)Ethyl-p-toluenesulfonamide ISO 9001:2015 REACH
N-Ethyl-4-methyl benzenesulfonamideEINECS 201-275-1992S798SJBNSC-68803DTXCID4053104-Toluenesulfonamide, N-ethyl-ETHYL P-TOLUENESULFONAMIDEOHPZPBNDOVQJMH-UHFFFAOYSA-

Database identifiers

CAS
1321-54-6、80-39-7
PubChem CID
6637
DTXSID
DTXSID5025310
ChEMBL
CHEMBL1492809
UNII
992S798SJB
EC Number
201-275-1
Nikkaji
J45.867H

Properties

Computed structural properties

XLogP
1.6
Topological polar surface area
54.6 Ų
Hydrogen bond donors
1
Hydrogen bond acceptors
3
Rotatable bonds
3
Heavy atoms
13

Experimental & physicochemical properties

Chemical ClassesNitrogen Compounds -> Sulfonamides
CosmeticsPlasticiser; Film forming
Solubilityless than 1 mg/mL at 70 °F (NTP, 1992)
Melting Point147 °F (NTP, 1992)
Food Contact Substances · 4 items

FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR

FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR

FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR

FCS -> FDA Inventory of Effective Food Contact Substance (FCS) Notifications

Physical Description · 3 items

Platelets (from dilute alcohol or ligroin) or off-white solid. (NTP, 1992)

Liquid

Solid; [CAMEO]

Physicochemical properties

Indirect Additives used in Food Contact Substances
ETHYL-P-TOLUENESULFONAMIDE
FDA 21 CFR
175.105 · 175.105
FDA UNII
992 S798SJB · 992S798SJB

Safety & regulation

GHS classification

GHS Classification · 5 items

This chemical does not meet GHS hazard criteria for 22.6% (19 of 84) of reports.

Warning

H315 (72.6%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 84 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory Information · 3 items

Chemical: Benzenesulfonamide, N-ethyl-4-methyl-

Benzenesulfonamide, N-ethyl-4-methyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Benzenesulfonamide, N-ethyl-4-methyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Benzenesulfonamide, N-ethyl-4-methyl-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Fire HazardsFlash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
Hazards SummaryA skin and strong eye irritant; [Sigma-Aldrich MSDS] See Toluenesulfonamide.
Reactive GroupAmines, Phosphines, and Pyridines
Reactivity Profile · 1 item

An amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Air and Water ReactionsInsoluble in water.

Safety & protection

Fire FightingFires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1 item

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1 item

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Personal Protective Equipment (PPE) · 1 item

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Chemistry & industry

Uses & manufacturing

UsesPermitted for use as an inert ingredient in non-food pesticide products; [EPA]
U.S. Production2023: 183,987 lb
Industry UsesPlasticizer
Household ProductsInformation on 4 consumer products that contain Ethyl tosylamide in the following categories is provided:
Use ClassificationCosmetics -> Plasticiser; Film forming
General Manufacturing Information · 2 items

Printing Ink Manufacturing

Benzenesulfonamide, N-ethyl-4-methyl-: ACTIVE

Suppliers100 total

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
湖北永阔科技有限公司027-59223108 15972152991 · [email protected]
湖北万得化工有限公司15377098680 15377098680 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
广州隽沐生物科技股份有限公司020-36607679; 13502246435 · [email protected]

Related reactions

13 records

Compound notes

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