Methyl p-toluenesulfonate

1.230 @ 25 DEG/25 °C

1.230-1.238 @25 °C

MONOCLINIC LEAFLETS OR PRISMS FROM ETHER-PETROLEUM ETHER

LIGHT BROWN CRYSTALS

WHITE DAMP CRYSTALS

Liquid

White vesicant solid; Solidifies at 24 deg C; [Hawley] White or light brown solid; mp = 28-29 deg C; [HSDB] Off-white low melting solid or clear liquid; mp = 27-28 deg C; [MSDSonline]

LOW-MELTING SOLID OR LIQUID

DECOMP @ 262 °C

Danger

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]；H311 (29.9%): Toxic in contact with skin [Danger Acute toxicity, dermal]；H314 (22.8%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]；H315 (76.9%): Causes skin irritation [Warning Skin corrosion/irritation]；H317 (97.2%): May cause an allergic skin reaction [Warning Sensitization, Skin]；H319 (35%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (26.2%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]；H411 (29.6%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P260, P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P319, P321, P330, P332+P317, P333+P317, P337+P317, P361+P364, P362+P364, P363, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 351 reports by companies from 26 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Chemical: Benzenesulfonic acid, 4-methyl-, methyl ester

Benzenesulfonic acid, 4-methyl-, methyl ester is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Benzenesulfonic acid, 4-methyl-, methyl ester are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 22-02-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/21794；Status: Active Update: 11-12-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/18934

Methyl 4-toluenesulphonate: Does not have an individual approval but may be used under an appropriate group standard

A strong skin and eye irritant; [Hawley] Urticaria and skin sensitization have been reported; [HSDB] A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation may cause chemical pneumonitis; May cause skin sensitization; [MSDSonline]

2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury.

1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur.

0 - Materials that in themselves are normally stable, even under fire conditions.

Acute Tox. 4 (100%)；Acute Tox. 3 (29.9%)；Skin Corr. 1B (22.8%)；Skin Irrit. 2 (76.9%)；Skin Sens. 1B (97.2%)；Eye Irrit. 2 (35%)；STOT SE 3 (26.2%)；Aquatic Chronic 2 (29.6%)

Skin corrosion/irritation - Category 2；Serious eye damage/eye irritation - Category 2

Skin corrosion/irritation - Category 1C；Serious eye damage/eye irritation - Category 1

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

1.0 [mg/m3]

11 [mg/m3]

68 [mg/m3]

...CONTACT WITH SOLN OR SOLID MAY GIVE RISE TO NO SYMPTOMS FOR SEVERAL HR. ... /THEN/ THERE MAY BE...VESICATION AT SITE OF CONTACT, FREQUENTLY WITH LITTLE... PAIN. VERY LARGE BULLAE MAY BE FORMED... GENERALIZED TOXIC SYMPTOMS DO NOT SEEM TO OCCUR AND...BURNS HEAL USUALLY WITH SOME PIGMENTATION...

...THERE HAVE BEEN FEW INSTANCES OF PULMONARY IRRITATION. ...ONE INSTANCE WAS NOTED OF URTICARIAL REACTION FROM HEATED VAPOR; SKIN SENSITIZATION ALSO OCCURS.

...STRONG IRRITANT TO...EYES.

HIGHLY TOXIC BY INHALATION; STRONG IRRITANT TO SKIN & EYES.

BD RATS RECEIVING SC 15 WEEKLY X 53 MG/KG FOR 470 DAYS: 7/10 HAD LOCAL SARCOMA, 1 BRONCHIAL, 1 MAMMARY & 1 OVARIAN CARCINOMA. /FROM TABLE/

Several direct acting mutagens were tested for mutagenic activity in adult Drosophila melanogaster when administered in feeding or as an injected dose. An inhibitor or cytochrome p450, 1-phenylimidazole, administered at concentrations of 2.5, 4 and 10 mmol, was not mutagenic in Drosophila. Methyl-p-toluenesulfonate applied orally was a weak mutagen. When administered simultaneously with 1-phenylimidazole, a concentration dependent increase was noted in mutagenic activity of methyl-p-toluenesulfonate. Following injection, mutagenesis by methyl-p-toluenesulfonate was considerable. Ethyl-p-toluenesulfonate demonstrated marginal mutagenesis in Drosophila when orally applied but was decidedly mutagenic on injection. Simultaneous treatment with 4 mmol 1-phenylimidazole and 1 mmole of ethyl-p-toluenesulfonate did not alter mutagenesis nor did treatment with diethylmaleate (glutathione depletion). Combined treatment with 2 mmol ethyl-p-toluenesulfonate and 2 mmol 1-phenylimidazole produced a statistically significant increase in mutagenesis. /It was concluded/ that weak mutagenesis by p-toluenesulfonates after feeding experiments compared to considerable effects after injection suggests metabolic deactivation in the gut.

The carcinogenic activity of 12 direct alkylating substances was tested in 535 BD rats. Local sarcomas were produced by the subcutaneous injections once a week of p-toluene sulfonic acid methylester. Only a jew tumors were observed following treatment with p-toluene sulfonic acid ethylester and p-toluenesulfonic acid butylester were not carcinogenic.

Chemical: Benzenesulfonic acid, 4-methyl-, methyl ester

Benzenesulfonic acid, 4-methyl-, methyl ester is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Benzenesulfonic acid, 4-methyl-, methyl ester are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 22-02-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/21794；Status: Active Update: 11-12-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/18934

Methyl 4-toluenesulphonate: Does not have an individual approval but may be used under an appropriate group standard

Used as methylating agent in organic synthesis and as a catalyst for alkyd resins; [HSDB]

METHYLATING AGENT IN ORGANIC SYNTHESIS

ACCELERATOR; CATALYST FOR ALKYD RESINS

CHEM INT FOR BASIC DYE C.I. 46000

(1977) 1.35X10+7 GRAMS (PRINCPL CUSTMS DISTS)

(1979) 7.99X10+6 GRAMS (PRINCPL CUSTMS DISTS)

2022: 119,181 lb；2021: 54,718 lb；2020: 31,482 lb

(1977) NOT PRODUCED COMMERCIALLY IN US

(1979) NOT PRODUCED COMMERCIALLY IN US

Fabricated Metal Product Manufacturing

Benzenesulfonic acid, 4-methyl-, methyl ester: ACTIVE