Glyprothiazol

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Basic information

CAS: 80-34-2
Standard SMILES: CC(C)c1nnc(NS(=O)(=O)c2ccc(N)cc2)s1
InChIKey: OPIGMRDAPFQALU-UHFFFAOYSA-N
Molecular formula: C11H14N4O2S2
Average molar mass: 298.4 g/mol
Monoisotopic mass: 298.05581805

Overview

Glyprothiazol is a sulfonamide derivative with antihyperglycemic activity. Like sulfonylureas, glyprothiazol is able to lower blood glucose levels by increasing the release of insulin from pancreatic beta cells.

Names & identifiers

Preferred name: Glyprothiazol
IUPAC: 4-amino-N-(5-propan-2-yl-1,3,4-thiadiazol-2-yl)benzenesulfonamide
English name: Glyprothiazol
Molecular formula: C11H14N4O2S2
Molecular weight: 0

Names & synonyms

GlyprothiazolGlyprothiazolePASITGliprotiazolGlyprothizolumGlyprothiazolumGlyprothiazol [INN:DCF]SulfaisopropylthiadiazoleRP 2254Gliprotiazol [INN-Spanish]VK-57Glyprothiazolum [INN-Latin]

Show more names

IPTD4-amino-N-(5-isopropyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide4-amino-N-(5-propan-2-yl-1,3,4-thiadiazol-2-yl)benzenesulfonamide4-azanyl-N-(5-propan-2-yl-1,3,4-thiadiazol-2-yl)benzenesulfonamide4-Amino-N-[5-(1-methylethyl)-1,3,4-thiadiazol-2-yl]benzenesulfonamide

VK 57UNII-1804FJN4MO1804FJN4MORP-2254GLYPROTHIZOLGlyprothiazol (INN)2254 R.P.N(sup 1)-(5-Isopropyl-1,3,4-thiadiazol-2-yl)sulfanilamide

Database identifiers

CAS: 80-34-2
PubChem CID: 66458
DTXSID: DTXSID80229994

Properties

Computed structural properties

XLogP: 1.3
Topological polar surface area: 135 Å²
Hydrogen bond donors: 2
Hydrogen bond acceptors: 7
Rotatable bonds: 4
Heavy atoms: 19
Formal charge: 0
Complexity: 388

Physicochemical properties

Density: 1.3753 · 1.3753 (rough estimate)
refractive index: 1.644 · 1.6440 (estimate)
Water Solubility: 218.7 mg/L · 218.7mg/L(37 ºC)
FDA UNII: 1804 FJN4MO · 1804FJN4MO
Toxicity: 50 oral · LD50 oral in rat: 3940mg/kg

Safety & regulation

Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.

GHS classification

GHS Classification · 4 items

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Hazard information

Hazard Classes and CategoriesSkin Irrit. 2 (100%)

Safety data

Toxicity: LD50 oral in rat: 3940mg/kg

Related reactions

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Compound notes

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