N-(4-Hydroxyphenyl)glycine (HCID 67149)

Overview

N-(p-hydroxyphenyl)glycine is a phenol that is the N-(4-hydroxyphenyl) derivative of glycine. Synthesised by reaction of p-aminophenol with chloracetic acid, it is used as a photographic developing agent. It has a role as an allergen. It is a glycine derivative, a member of phenols and a non-proteinogenic alpha-amino acid.

Names & identifiers

Preferred name: N-(4-Hydroxyphenyl)glycine
IUPAC: 2-(4-hydroxyanilino)acetic acid
English name: N-(4-Hydroxyphenyl)glycine
Molecular formula: C8H9NO3
Molecular weight: 167.16

Names & synonyms

N-(4-Hydroxyphenyl)glycineGlycinGlycine, N-(4-hydroxyphenyl)-N-(p-Hydroxyphenyl)glycineIconylMonazolGlitsinNPHPGGlyconylN-p-hydroxyphenylglycineN-PHPGGlycine, N-(p-hydroxyphenyl)-

Show more names

p-hydroxyphenylglycineGLYCIN, PHOTOPhotoglycine.TIMTEC-BB SBB003884PARA-GLYCINYLPHENOLGlycine-Glycine98%MinGlycine [photographic]LABOTEST-BB LT00452650HYDROXY-N-PHENYLGLYCINE

N-4-hydroxyphenylglycineUNII-3ET7L3AG0VNSC 92673ET7L3AG0VD,L-(4-hydroxyphenyl)glycineCHEBI:55443NSC-9267para-hydroxyphenyl glycine

Database identifiers

CAS: 122-87-2
PubChem CID: 67149
DTXSID: DTXSID9059547
ChEBI: CHEBI:55443
UNII: 3ET7L3AG0V
EC Number: 204-580-8
Nikkaji: J59.963H

Properties

Computed structural properties

XLogP: 0.3
Topological polar surface area: 69.6 Å²
Hydrogen bond donors: 3
Hydrogen bond acceptors: 4
Rotatable bonds: 3
Heavy atoms: 12
Formal charge: 0
Complexity: 152

Experimental & physicochemical properties

Chemical ClassesNitrogen Compounds -> Other Aromatics (Nitrogen)

Physical DescriptionShiny solid; [Merck Index] White or light brown powder; [Alfa Aesar MSDS]

Physicochemical properties

Melting point: 244 °C · 244 °C (dec.)(lit.)
Boiling point: 295.73 °C · 295.73°C (rough estimate)
Density: 1.2917 · 1.2917 (rough estimate)
refractive index: 1.581 · 1.5810 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: 1 · almost transparency in HCl1+1
form: Powder
pka: 2.17 · 2.17±0.10(Predicted)
color: White to beige-brown or brown-gray
Merck: 14 · 14,4837
Major Application: peptide synthesis
InChI: 1S/C8H9NO3/c10-7-3-1-6(2-4-7)9-5-8(11)12/h1-4,9-10H,5H2,(H,11,12)
InChIKey: WRUZLCLJULHLEY-UHFFFAOYSA-N
SMILES: OC(=O)CNc1ccc(O)cc1
CAS DataBase Reference: 122 · 122-87-2(CAS DataBase Reference)
FDA UNII: 3 ET7L3AG0V · 3ET7L3AG0V
EPA Substance Registry System: Glycine, N-(4-hydroxyphenyl)- (122-87-2)
UNSPSC Code: 12352209 · 12352209
NACRES: 22 · NA.22
Symbol(GHS): 7 · GHS07
Signal word: Warning
Hazard statements: 315 · H315-H319-H335
Precautionary statements: 261 · P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs: Respiratory system
PPE: 95 · dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes: Xi
Risk Statements: 36 · 36/37/38-R36/37/38
Safety Statements: 26 · 26-36-S36-S26
WGK Germany: 3 · 3
TSCA: TSCA listed
HS Code: 29225000 · 29225000
Storage Class: 11 · 11 - Combustible Solids
Hazard Classifications: 2 Skin · Eye Irrit. 2Skin Irrit. 2STOT SE 3

Safety & regulation

GHS classification

GHS Classification · 4 items

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 44 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory InformationChemical: Glycine, N-(4-hydroxyphenyl)-

Hazards SummaryA skin and strong eye irritant; [Alfa Aesar MSDS]

Hazard Classes and CategoriesSkin Irrit. 2 (100%)

Safety data

PPE: dust mask type N95 (US), Eyeshields, Gloves
wgk: 3
tsca: TSCA listed
hs_code: 29225000
risk_code: 36/37/38-R36/37/38
Signal word: Warning
Symbol(GHS): GHS07
hazard_code: Xi
safety_code: 26-36-S36-S26
Storage Class: 11 - Combustible Solids
target organs: Respiratory system
Hazard statements: H315-H319-H335
Hazard Classifications: Eye Irrit. 2Skin Irrit. 2STOT SE 3
Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338

Chemistry & industry

Uses & manufacturing

Uses · 2 items

Used as a photographic developer, acid indicator in bacteriology, and reagent (determination of iron, phosphorus, and silicon); [Merck Index]

Photographic Processing [Category: Other]

General Manufacturing InformationGlycine, N-(4-hydroxyphenyl)-: ACTIVE

Applications

UsesPhotographic developer. In determination of iron; detection and determination of phosphorus and silicon. Acid indicator in bacteriology.

Suppliers50 total

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]

杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]

Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]

浙江珲达生物科技有限公司0571-89903022 18679456698 · [email protected]

Additional notes

DefinitionChEBI: A phenol that is the N-(4-hydroxyphenyl) derivative of glycine. Synthesised by reaction of p-aminophenol with chloracetic acid, it is used as a photographic developing agent.