N-(4-Hydroxyphenyl)glycine
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Basic information
- CAS
122-87-2- Standard SMILES
O=C(O)CNc1ccc(O)cc1- InChIKey
WRUZLCLJULHLEY-UHFFFAOYSA-N- Molecular formula
- C8H9NO3
- Average molar mass
- 167.16 g/mol
- Monoisotopic mass
- 167.05824315
Overview
N-(p-hydroxyphenyl)glycine is a phenol that is the N-(4-hydroxyphenyl) derivative of glycine. Synthesised by reaction of p-aminophenol with chloracetic acid, it is used as a photographic developing agent. It has a role as an allergen. It is a glycine derivative, a member of phenols and a non-proteinogenic alpha-amino acid.
Names & identifiers
- Preferred name
- N-(4-Hydroxyphenyl)glycine
- IUPAC
- 2-(4-hydroxyanilino)acetic acid
- English name
- N-(4-Hydroxyphenyl)glycine
- Molecular formula
- C8H9NO3
- Molecular weight
- 167.16
Names & synonyms
N-(4-Hydroxyphenyl)glycineGlycinGlycine, N-(4-hydroxyphenyl)-N-(p-Hydroxyphenyl)glycineIconylMonazolGlitsinNPHPGGlyconylN-p-hydroxyphenylglycineN-PHPGGlycine, N-(p-hydroxyphenyl)-
Show more names
p-hydroxyphenylglycineGLYCIN, PHOTOPhotoglycine.TIMTEC-BB SBB003884PARA-GLYCINYLPHENOLGlycine-Glycine98%MinGlycine [photographic]LABOTEST-BB LT00452650HYDROXY-N-PHENYLGLYCINE
N-4-hydroxyphenylglycineUNII-3ET7L3AG0VNSC 92673ET7L3AG0VD,L-(4-hydroxyphenyl)glycineCHEBI:55443NSC-9267para-hydroxyphenyl glycine
Database identifiers
- CAS
122-87-2- PubChem CID
- 67149
- DTXSID
DTXSID9059547- ChEBI
CHEBI:55443- UNII
Properties
Computed structural propertiesFilling in
- XLogP
- 0.3
- Topological polar surface area
- 69.6 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 3
- Heavy atoms
- 12
- Formal charge
- 0
- Complexity
- 152
Experimental & physicochemical properties
Chemical ClassesNitrogen Compounds -> Other Aromatics (Nitrogen)
Physical DescriptionShiny solid; [Merck Index] White or light brown powder; [Alfa Aesar MSDS]
Physicochemical properties
- Melting point
- 244 °C · 244 °C (dec.)(lit.)
- Boiling point
- 295.73 °C · 295.73°C (rough estimate)
- Density
- 1.2917 · 1.2917 (rough estimate)
- refractive index
- 1.581 · 1.5810 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- 1 · almost transparency in HCl1+1
- form
- Powder
- pka
- 2.17 · 2.17±0.10(Predicted)
- color
- White to beige-brown or brown-gray
- Merck
- 14 · 14,4837
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 44 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory InformationChemical: Glycine, N-(4-hydroxyphenyl)-
Hazards SummaryA skin and strong eye irritant; [Alfa Aesar MSDS]
Hazard Classes and CategoriesSkin Irrit. 2 (100%)
Safety data
- PPE
- dust mask type N95 (US), Eyeshields, Gloves
- wgk
- 3
- tsca
- TSCA listed
- hs_code
- 29225000
- risk_code
- 36/37/38-R36/37/38
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xi
- safety_code
- 26-36-S36-S26
- Storage Class
- 11 - Combustible Solids
- target organs
- Respiratory system
- Hazard statements
Chemistry & industry
Uses & manufacturing
Uses
Used as a photographic developer, acid indicator in bacteriology, and reagent (determination of iron, phosphorus, and silicon); [Merck Index]
Photographic Processing [Category: Other]
General Manufacturing InformationGlycine, N-(4-hydroxyphenyl)-: ACTIVE
Applications
UsesPhotographic developer. In determination of iron; detection and determination of phosphorus and silicon. Acid indicator in bacteriology.
Additional notes
DefinitionChEBI: A phenol that is the N-(4-hydroxyphenyl) derivative of glycine. Synthesised by reaction of p-aminophenol with chloracetic acid, it is used as a photographic developing agent.
Related reactions
27 records
Compound notes
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