Girard-T reagent
Basic information
- CAS
123-46-6- Standard SMILES
C[N+](C)(C)CC(=O)NN.[Cl-]- InChIKey
YSULOORXQBDPCU-UHFFFAOYSA-N- Molecular formula
- C5H14N3O.Cl
- Average molar mass
- 167.64 g/mol
- Monoisotopic mass
- 167.0825398
Overview
used for separating ketosteroids; RN given refers to chloride
Names & identifiers
- Preferred name
- Girard-T reagent
- IUPAC
- (2-hydrazinyl-2-oxoethyl)-trimethylazanium chloride
- English name
- Girard's Reagent T
- Molecular formula
- C5H14N3O.Cl
- Molecular weight
- 167.64
Names & synonyms
Girard's reagent T123-46-6Girard reagent TBetaine hydrazide hydrochloride(Carboxymethyl)trimethylammonium chloride hydrazideTrimethylaminoacetohydrazide chlorideEthanaminium, 2-hydrazino-N,N,N-trimethyl-2-oxo-, chlorideOO3MF0US46GIRARD-T REAGENTNSC-9242Ammonium, (carboxymethyl)trimethyl-, chloride, hydrazideDTXSID00883315
Show more names
Girard’s reagent TGIRARD TGirardent TGIRARD'S Tirard's ReaggirardtreagentGrard'sreagentTGIRARD-REAGENT T
Ethanaminium, 2-hydrazino-N,N,N-trimethyl-2-oxo-RefChem:567996DTXCID601022853204-629-3Girard T reagent(Hydrazinocarbonylmethyl)trimethylammonium chlorideCarbazoylmethyltrimethylammonium chloridegirard-t
Database identifiers
- CAS
123-46-6- PubChem CID
- 67156
- DTXSID
DTXSID00883315- UNII
- OO3MF0US46
- EC Number
- 204-629-3
Properties
Computed structural properties
- Topological polar surface area
- 55.1 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 2
- Heavy atoms
- 10
- Formal charge
- 0
- Complexity
- 105
Physicochemical properties
- Melting point
- 188 · 188-192 °C (dec.) (lit.)
- Density
- 1.3799 · 1.3799 (rough estimate)
- refractive index
- 1.54 · 1.5400 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to crystal
- color
- White to Almost white
- Water Solubility
- soluble
- Merck
- 14 · 14,4429
- BRN
- 3727163 · 3727163
- InChI
- InChI=1S/C5H13N3O.ClH/c1-8(2,3)4-5(9)7-6;/h4,6H2,1-3H3;1H
- InChIKey
- YSULOORXQBDPCU-UHFFFAOYSA-N
- SMILES
- [N+](C)(C)(C)CC(=O)NN.[Cl-]
- CAS DataBase Reference
- 123 · 123-46-6(CAS DataBase Reference)
- FDA UNII
- 3 MF0US46 · OO3MF0US46
- EPA Substance Registry System
- 2 · Ethanaminium, 2-hydrazino-N,N,N-trimethyl-2-oxo-, chloride (123-46-6)
- UNSPSC Code
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Hazard information
Regulatory Information
Chemical: Ethanaminium, 2-hydrazino-N,N,N-trimethyl-2-oxo-, chloride
Ethanaminium, 2-hydrazino-N,N,N-trimethyl-2-oxo-, chloride: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesSkin Irrit. 2 (100%)
Safety data
- F
- 21
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- CP3150000
- hs_code
- 29280000
- risk_code
- 44-36/37/38-20/22-11-R44-R36/37/38-R20/22-R11
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xn-F,Xn,F
- safety_code
- 22-24/25-36/37/39-26-16-S36/37/39-S26-S16
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H315-H319
Chemistry & industry
Uses & manufacturing
General Manufacturing InformationEthanaminium, 2-hydrazinyl-N,N,N-trimethyl-2-oxo-, chloride (1:1): ACTIVE
Applications
UsesGirard''s Reagent T is a derivatizing agent used to generate permanent cationic charge at the reducing ends of neutral oligosaccharides for easier quantification in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS).
UsesGirard′s reagent T may be used as a derivatizing reagent for the determination of 5-Formyl-2′-deoxyuridine in cellular DNA samples using liquid chromatography–tandem mass spectrometry (LC–MS/MS) technique. Reducing saccharides can be derivatized by Girard′s reagent T and this can be analyzed by matrix-assisted laser desorption/ionization coupled to time of flight mass spectrometry (MALDI-TOF-MS) technique.
Upstream & downstream products
Upstream raw materials
Related reactions
8 records
Compound notes
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