Pyrazolo(1,5-a)pyridine
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Basic information
- CAS
274-56-6- Standard SMILES
c1ccn2nccc2c1- InChIKey
DVUBDHRTVYLIPA-UHFFFAOYSA-N- Molecular formula
- C7H6N2
- Average molar mass
- 118.14 g/mol
- Monoisotopic mass
- 118.05309819
Names & identifiers
- Preferred name
- Pyrazolo(1,5-a)pyridine
- IUPAC
- pyrazolo[1,5-a]pyridine
- English name
- Pyrazolo[1,5-a]pyridine
- Molecular formula
- C7H6N2
- Molecular weight
- 118.14
Names & synonyms
Pyrazolo[1,5-a]pyridine274-56-6Pyrazolo(1,5-a)pyridineDTXSID10181819RefChem:177463DTXCID00104310836-855-93-AzaindolineMFCD08752622Pyrazolo(2,3-a)pyridine3-AzaindolizineAKOS006290545
Show more names
1H-Pyrazolo[1,5-a]pyridinePyrazolo[1,5-a]pyridine,97%6,7a-dimethyl-2,3,5,6-tetrahydrooxazolo[2,3-b]oxazole
AB48944DS-16354Pyrazolo[2,3-a]pyridineF2199-01041,7a-DiazaindenePyrazolo[2,3-aSCHEMBL9729SCHEMBL9730
Database identifiers
- CAS
274-56-6- PubChem CID
- 67507
- DTXSID
DTXSID10181819- ChEMBL
CHEMBL577543- EC Number
- 836-855-9
- Nikkaji
- J101.040I
Properties
Computed structural propertiesFilling in
- XLogP
- 1.1
- Topological polar surface area
- 17.3 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 1
- Rotatable bonds
- 0
- Heavy atoms
- 9
- Formal charge
- 0
- Complexity
- 103
Physicochemical properties
- Boiling point
- 37 · 37-39℃/0.2mm
- Density
- 1.14 · 1.14±0.1 g/cm3(Predicted)
- refractive index
- 1.6075 · 1.6075
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.83 · 2.83±0.30(Predicted)
- form
- Liquid
- color
- Colorless to red or brown
- InChI
- InChI=1S/C7H6N2/c1-2-6-9-7(3-1)4-5-8-9/h1-6H
- InChIKey
- DVUBDHRTVYLIPA-UHFFFAOYSA-N
- SMILES
- C12=CC=NN1C=CC=C2
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 315 · H315-H319-H335
- Precautionary statements
- 261 · P261-P280a-P304+P340-P305+P351+P338-P405-P501a
- HS Code
- 2933399990 · 2933399990
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H303 (66.7%): May be harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 3 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Hazard Classes and CategoriesAcute Tox. 5 (66.7%)
Safety data
- hs_code
- 2933399990
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H315-H319-H335
- Precautionary statements
- P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Chemistry & industry
Applications
DescriptionPyrazolo[1,5-a]pyridines, a class of fused heteroaromatic bicyclic compounds, have been investigated for their pharmacological and biological activities. They are used as dopamine D2/D3/D4 antagonists, anti-herpetic agents, p38 kinase inhibitors, PI3 kinase inhibitors, antitubercular agents, EP1 receptor antagonists, 5HT3-antagonists, melatonin receptor (MT1/MT2) ligands, Mcl-1Bcl-xL dual inhibitors, and corticotropin-releasing factor 1 antagonists. Pyrazolo[1,5-a]pyridine has been used as a fluorophore in the research of Zhang et al. and exhibited high quantum yield (0.64, pH 2.4), high selectivity and sensitivity, and extremely short response time[1].
Upstream & downstream products
Upstream raw materials
Downstream products
Related reactions
4 records
Compound notes
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