Basic information
- CAS
4312-32-7- Standard SMILES
c1cc2c(c3c1CC1c4cc5c(cc4CCN1C3)OCO5)OCO2- InChIKey
UXYJCYXWJGAKQY-UHFFFAOYSA-N- Molecular formula
- C19H17NO4
- Average molar mass
- 323.3 g/mol
- Monoisotopic mass
- 323.11575802
Overview
Tetrahydrocoptisine has been reported in Fibraurea recisa, Corydalis ternata, and other organisms with data available.
Names & identifiers
- Preferred name
- (+-)-Stylopine
- IUPAC
- 5,7,17,19-tetraoxa-13-azahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-2,4(8),9,15(23),16(20),21-hexaene
- English name
- STYLOPINE, (-)-(RG)(CALL)
- Molecular formula
- C19H17NO4
- Molecular weight
- 323.34258
Names & synonyms
Tetrahydrocoptisine4312-32-75,7,17,19-tetraoxa-13-azahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-2,4(8),9,15(23),16(20),21-hexaeneDTXSID50904180(+-)-Stylopine5,7,17,19-tetraoxa-13-azahexacyclo(11.11.0.02,10.04,8.015,23.016,20)tetracosa-2,4(8),9,15(23),16(20),21-hexaeneRefChem:1049045DTXCID401332424dl-Stylopine(-)-STYLOPINE(R,S)-Stylopine(RS)-Stylopine
Show more names
Nsc404529
( inverted exclamation markA)-Stylopine6,7,12b,13-Tetrahydro-4H-[1,3]dioxolo[4',5':7,8]isoquinolino[3,2-a][1,3]dioxolo[4,5-g]isoquinoline(+/-)-StylopineSTYLOPINE, (-)-(RG)(CALL)NSC 110382Coptisine, tetrahydro-(.+-.)-TetrahydrocoptisineSTYLOPINE, (+/-)-(P)
Database identifiers
- CAS
4312-32-7、7461-02-1- PubChem CID
- 6770
- DTXSID
DTXSID50904180- ChEMBL
Properties
Computed structural properties
- XLogP
- 3
- Topological polar surface area
- 40.2 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 0
- Heavy atoms
- 24
- Formal charge
- 0
- Complexity
- 502
Physicochemical properties
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Cryst.
- InChI
- InChI=1S/C19H17NO4/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14/h1-2,6-7,15H,3-5,8-10H2
- InChIKey
- UXYJCYXWJGAKQY-UHFFFAOYSA-N
- SMILES
- O1C([H])([H])OC2C([H])=C([H])C3=C(C1=2)C([H])([H])N1C([H])([H])C([H])([H])C2=C([H])C4=C(C([H])=C2C1([H])C3([H])[H])OC([H])([H])O4
Chemistry & industry
Applications
DescriptionTetrahydrocoptisine is an active anti-inflammatory constituent by inhibition of TNF-α, IL-6 and NO production possibly via down-regulation of NF-κB activation, phospho-ERK1/2 and phospho-p38MAPK signal pathways.Tetrahydrocoptisine has gastroprotective activity, is attributed to reducing NO production and adjusting the pro-inflammatory cytokine, inhibited neutrophil accumulation and NF-κB expression.
Suppliers34 total
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
武汉众志诚生物技术有限公司13628624121 13628604890 · [email protected]
湖北丹鼎医药科技有限公司18917019315（微信同号） 17701422019 · [email protected]
Hangzhou Sage Chemical Co., Ltd.+86057186818502 13588463833 · [email protected]
InvivoChem中国13549236410 · [email protected]
武汉市皇臻生物化工有限公司13795480948 · [email protected]
Chengdu Youngshe Chemical Co., Ltd.+86-18108235634 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…