CAS 356-42-3 Pentafluoropropionic anhydride (HCID 67742)

Names & identifiers

Preferred name: Pentafluoropropionic anhydride
IUPAC: 2,2,3,3,3-pentafluoropropanoyl 2,2,3,3,3-pentafluoropropanoate
English name: Perfluoropropionic anhydride
Molecular formula: C6F10O3
Molecular weight: 310.05

Names & synonyms

Pentafluoropropionic anhydride356-42-3Perfluoropropionic anhydridepentafluoropropanoic anhydridePentafluoropropionic acid anhydride2,2,3,3,3-pentafluoropropanoyl 2,2,3,3,3-pentafluoropropanoatePropanoic acid, pentafluoro-, anhydridePerfluoropropionic acid anhydridePropionic acid, pentafluoro-, anhydride0LFE7U11O5DTXSID70870515NSC-174167

Show more names

PFPAPFAAPentafluoropanoic anhydridePENTAFLUORPROPIONSREANHYDRIDuoropropionic Acid AnhydridePENTAFLUORPROPIONSUREANHYDRID

Propanoic acid, 2,2,3,3,3-pentafluoro-, 1,1'-anhydridePFPAHRefChem:171372DTXCID90818232206-604-2C6F10O3MFCD000004292,2,3,3,3-pentafluoropropanoic anhydride

Database identifiers

CAS: 356-42-3
PubChem CID: 67742
DTXSID: DTXSID70870515
UNII: 0LFE7U11O5
EC Number: 206-604-2
Nikkaji: J208.859B

Properties

Computed structural properties

XLogP: 3.5
Topological polar surface area: 43.4 Å²
Hydrogen bond donors: 0
Hydrogen bond acceptors: 13
Rotatable bonds: 4
Heavy atoms: 19
Formal charge: 0
Complexity: 342

Experimental & physicochemical properties

Chemical ClassesOther Classes -> Acid Anhydrides, Other

PFAS · 2 items

PFAS -> Other/unspecified

Physical DescriptionColorless liquid; [MSDSonline]

Physicochemical properties

Melting point: -43 · -43
Boiling point: 69 · 69-70 °C/735 mmHg (lit.)
Density: 1.571 g/mL · 1.571 g/mL at 25 °C (lit.)
refractive index: 1.3 · 1.3
Flash point: None
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: Liquid
color: Clear colorless
Specific Gravity: 1.571 · 1.571
Water Solubility: Reacts with water.
Sensitive: Moisture Sensitive
BRN: 1806446 · 1806446
Stability: Hygroscopic, Moisture Sensitive
InChI: 1S/C6F10O3/c7-3(8,5(11,12)13)1(17)19-2(18)4(9,10)6(14,15)16
InChIKey: XETRHNFRKCNWAJ-UHFFFAOYSA-N
SMILES: FC(F)(F)C(F)(F)C(=O)OC(=O)C(F)(F)C(F)(F)F
CAS DataBase Reference: 356 · 356-42-3(CAS DataBase Reference)
FDA UNII: 0 LFE7U11O5 · 0LFE7U11O5
NIST Chemistry Reference: Pentafluoropropionic anhydride(356-42-3)
EPA Substance Registry System: Pentafluoropropionic anhydride (356-42-3)
UNSPSC Code: 12352100 · 12352100
NACRES: 22 · NA.22
Symbol(GHS): 5 · GHS05
Signal word: Danger
Hazard statements: 314 · H314
Precautionary statements: 280 · P280-P305+P351+P338-P310
PPE: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Hazard Codes: C
Risk Statements: 34 · 34-14
Safety Statements: 26 · 26-36/37/39-45
RIDADR: 3265 · UN 3265 8/PG 2
WGK Germany: 3 · 3
F: 10 · 10-21
Hazard Note: Corrosive
TSCA: TSCA listed
HazardClass: 8 · 8
PackingGroup: II
HS Code: 29159000 · 29159000
Storage Class: 8 A · 8A - Combustible corrosive hazardous materials
Hazard Classifications: 1 B · Skin Corr. 1B

Safety & regulation

GHS classification

GHS Classification · 4 items

Danger

H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

P260, P261, P264, P271, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P363, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 11 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory InformationPropanoic acid, pentafluoro-, anhydride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Hazards SummaryReacts violently with water; A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation may cause chemical pneumonitis; [MSDSonline]

Hazard Classes and CategoriesSkin Corr. 1B (100%)

Toxicology

Adverse EffectsDermatotoxin - Skin burns.

Safety data

F: 10-21
PPE: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
wgk: 3
tsca: TSCA listed
ridadr: UN 3265 8/PG 2
hs_code: 29159000
risk_code: 34-14
Signal word: Danger
Symbol(GHS): GHS05
hazard_code: C
hazard_note: Corrosive
safety_code: 26-36/37/39-45
hazard_class: 8
Storage Class: 8A - Combustible corrosive hazardous materials
packing_group: II
Hazard statements: H314
Hazard Classifications: Skin Corr. 1B
Precautionary statements: P280-P305+P351+P338-P310

Chemistry & industry

Uses & manufacturing

General Manufacturing InformationPropanoic acid, 2,2,3,3,3-pentafluoro-, 1,1'-anhydride: ACTIVE

Applications · 1 item

UsesPentafluoropropionic anhydride act as a derivatising agent of amines and alcohols. It is used in the in preparation of halogenated derivatives of phenolic acids, required for determination of some biologically important acids in cerebrospinal fluid, as derivatization reagent in detection of 1,2,3,4-tetrahydroisoquinoline and 1-methyl-1,2,3,4-tetrahydroisoquinoline as endogenous amines from non-treated rat brain by GC-multiple ion detection and in simultaneous determination of the major metabolites of dopamine in rat striatum by gas-liquid chromatography.