Basic information
- CAS
460-73-1- Standard SMILES
FC(F)CC(F)(F)F- InChIKey
MSSNHSVIGIHOJA-UHFFFAOYSA-N- Molecular formula
- C3H3F5
- Average molar mass
- 134.05 g/mol
- Monoisotopic mass
- 134.0154912
Overview
Pentafluoropropane is under investigation in clinical trial NCT01673061 (Vapocoolant Spray for Numbing Small Boils Before Incision and Drainage).
Names & identifiers
- Preferred name
- 1,1,1,3,3-Pentafluoropropane
- IUPAC
- 1,1,1,3,3-pentafluoropropane
- English name
- 1,1,1,3,3-Pentafluoropropane
- Molecular formula
- C3H3F5
- Molecular weight
- 134.05
Names & synonyms
1,1,1,3,3-Pentafluoropropane460-73-1HFC-245fapentafluoropropaneHFC 245faF 245faR 245faEnovate 3000TA9UOF49CYHFC-245APropane, 1,1,1,3,3-pentafluoro-HFC245A
Show more names
R-245fa1,1,1,3,3-PentafluorpropanFC-245faHCF-245FAHCFC-245fa1,1,1,3,3-Pentafluor1,1,1,3,3-pentafluorpropane1,1,3,3,3-Pentafluoropropane
HFC 245ADTXSID6052110RefChem:70833DTXCID4030679419-170-6610-280-1MFCD00236696UNII-TA9UOF49CY
Database identifiers
- CAS
460-73-1- PubChem CID
- 68030
- DTXSID
DTXSID6052110- UNII
- TA9UOF49CY
- EC Number
- 419-170-6、610-280-1
- Nikkaji
- J28.345B
Properties
Computed structural properties
- XLogP
- 2.5
- Topological polar surface area
- 0 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 1
- Heavy atoms
- 8
- Formal charge
- 0
- Complexity
- 62.6
Experimental & physicochemical properties
PFAS
PFAS -> PFAS with analytical method available
PFAS -> PFAS identified in REACH Regulation EC No. 1272/2008
DrugsPharmaceuticals -> Listed in ZINC15
SolventsSolvents -> Chlorofluorocarbons
SpringerMaterials PropertiesDielectric constant
Density1.32 @25 °C
Boiling Point15.3 °C @760 [mm Hg]
Vapor Pressure935 [mm Hg] @20 °C
Physical Description
Gas Vapor; Liquid
Colorless compressed gas or liquefied gas with a slight ethereal odor; [CHEMINFO] Ether-like odor; [MSDSonline]
Physicochemical properties
- Melting point
- -102.1 °C · -102.1°C
- Boiling point
- 15 · 15,3°C
- Density
- 1.32 · 1.32
- refractive index
- 1.2803 · 1.2803 (estimate)
- Stability
- Stable.
- Cosmetics Ingredients Functions
- PROPELLANTSOLVENTFRAGRANCE
- CAS DataBase Reference
- 460 · 460-73-1(CAS DataBase Reference)
- EWG's Food Scores
- 4 · 4
- FDA UNII
- 9 UOF49CY · TA9UOF49CY
- NIST Chemistry Reference
- 1 · 1,1,1,3,3-Pentafluoropropane (R245fa)(460-73-1)
- EPA Substance Registry System
- -245 fa · HFC-245fa (460-73-1)
- ECETOC JACC REPORT
- 1 · 1,1,1,3,3-Pentafluoropropane (460-73-1)
- Symbol(GHS)
- 4 · GHS04,GHS07
- Signal word
- Warning
- Hazard statements
- 280 · H280-H319-H335
- Precautionary statements
- 261 · P261-P271-P280
- Safety Statements
- 3 · 3/7-9-23
- RIDADR
- 3163 · 3163
- TSCA
- TSCA listed
- HazardClass
- 2.2 · 2.2
- HS Code
- 2903392710 · 2903392710
- REACH Registrations
- Active
Safety & regulation
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 0.2% (1 of 559) of reports.
Warning
H280 (99.8%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]
P410+P403</a, and a href="https://pubchem.ncbi.nlm.nih.gov/ghs/#P410+P403">P410+P403 (click each P-code to see the statement)
Aggregated GHS information provided per 559 reports by companies from 2 notifications to the ECHA C&L Inventory.
This chemical does not meet GHS hazard criteria for 42.7% (64 of 150) of reports.
Hazard information
Regulatory Information
Chemical: 1,1,1,3,3-Pentafluoropropane
Propane, 1,1,1,3,3-pentafluoro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Propane, 1,1,1,3,3-pentafluoro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.
Status: Active Update: 07-03-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/18560
Propane, 1,1,1,3,3-pentafluoro-: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryEffects in high-dose animal studies include ataxia and respiratory depression; [MSDSonline]
Hazard Classes and Categories
Press. Gas (Liq.) (99.8%)
Eye Irrit. 2 (26%)
Safety & protection
Protective Action Criteria (PAC)
900 [ppm]
9900 [ppm]
59000 [ppm]
Toxicology
Adverse EffectsNeurotoxin - Acute solvent syndrome
Toxicity DataLCLo (mice) = 150,000 ppm/2h
Safety data
- tsca
- TSCA listed
- ridadr
- 3163
- hs_code
- 2903392710
- Signal word
- Warning
- Symbol(GHS)
- GHS04,GHS07
- safety_code
- 3/7-9-23
- hazard_class
- 2.2
- Hazard statements
- H280-H319-H335
- REACH Registrations
- Active
- Precautionary statements
- P261-P271-P280
Chemistry & industry
Uses & manufacturing
UsesUsed as a blowing agent; [MSDSonline] Being developed to be used as a refrigerant and blowing agent; [AIHA]
U.S. Production2023: 10,000,000 - <50,000,000 lb
Consumer UsesFoamant
Industry UsesIntermediate
General Manufacturing Information
Industrial Gas Manufacturing
Propane, 1,1,1,3,3-pentafluoro-: ACTIVE
Applications
UsesHFC 245fa was developed as a replacement for the fully halogenated chlorofluorocarbons as a foam-blowing agent and refrigerant.
Related reactions
5 records
Compound notes
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