4,4'-Butylidenebis(3-methyl-6-tert-butylphenol)

Dry Powder

White solid; [HSDB] White to off-white powder; [MSDSonline]

This chemical does not meet GHS hazard criteria for 41.1% (120 of 292) of reports.

Warning

H315 (15.4%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (15.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (14.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]；H410 (24.3%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]；H412 (18.8%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]；H413 (14.7%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]

P261, P264, P264+P265, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 292 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Reported as not meeting GHS hazard criteria per 120 of 292 reports by companies.；There are 8 notifications provided by 172 of 292 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Chemical: Phenol, 4,4'-butylidenebis[2-(1,1-dimethylethyl)-5-methyl-

Phenol, 4,4'-butylidenebis[2-(1,1-dimethylethyl)-5-methyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Phenol, 4,4'-butylidenebis[2-(1,1-dimethylethyl)-5-methyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 05-08-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/13368

Phenol, 4,4'-butylidenebis[2-(1,1-dimethylethyl)-5-methyl-: Does not have an individual approval but may be used under an appropriate group standard

Oral LDLo (rat) = 17,000 mg/kg; Effects included somnolence, altered food intake, and gastritis; [RTECS] Acute and long term feeding studies of rats: liver effects including hyperemia, increased weight, and hepatocellular necrosis; [eChemPortal: HPVIS] May cause irritation; May have effects on the liver and lymph nodes, based on animal studies; [MSDSonline]

ACUTE TOXICITY OF SANTOWHITE POWDER IS LOWER THAN THAT OF... /4-4'-THIO-BIS(6-TERT-BUTYL-M-CRESOL) IN RATS/. APPROX LETHAL DOSE FOR RATS IS 17 G/KG.../BEING ADDED TO FEED/.

HEPATIC LIPIDS WERE STUDIED IN MALE RATS GIVEN SANTOWHITE POWDER AT A LEVEL OF 1.135 MMOL% FOR 1 WK. SANTOWHITE POWDER INDUCED FATTY LIVER & INCREASED TRIGLYCERIDE, DIGLYCERIDE & CHOLESTERYL-ESTER CONCN, 7.1-, 5.8-, & 6.1-FOLD, RESPECTIVELY. PLASMA TRIGLYCERIDES, TOTAL CHOLESTEROL, & NONESTERIFIED FATTY ACIDS WERE MARKEDLY DECREASED. THE FATTY LIVER APPEARED TO RESULT MAINLY FROM DEFECTIVE FAT EXCRETION FROM THE LIVER.

Chemical: Phenol, 4,4'-butylidenebis[2-(1,1-dimethylethyl)-5-methyl-

Phenol, 4,4'-butylidenebis[2-(1,1-dimethylethyl)-5-methyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Phenol, 4,4'-butylidenebis[2-(1,1-dimethylethyl)-5-methyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 05-08-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/13368

Phenol, 4,4'-butylidenebis[2-(1,1-dimethylethyl)-5-methyl-: Does not have an individual approval but may be used under an appropriate group standard

Used as antioxidant for natural and synthetic rubber and latex; [HSDB]

ANTIOXIDANT FOR RUBBER, DRY OR LATEX

ANTIOXIDANT FOR SYNTHETIC RUBBERS & LATEXES

ANTIOXIDANT FOR NATURAL RUBBER & LATEX

Plastics -> Typical concentration range in plastic materials -> 0.5%

(1979) No Data

(1981) No Data

(1979) No Data

(1981) No Data

2023: 100,000 - <250,000 lb；2022: 250,000 - <400,000 lb；2021: 400,000 - <550,000 lb；2020: 400,000 - <550,000 lb

(1979) PROBABLY GREATER THAN 4.54X10+5 GRAMS

(1981) PROBABLY GREATER THAN 4.54X10+5 GRAMS

Plastics -> Other functions -> Other stabiliser

Plastics -> Antioxidants

Plastics -> Polymer Type -> PVC (rigid); PA

Not Known or Reasonably Ascertainable；Plastics Material and Resin Manufacturing；Synthetic Rubber Manufacturing

Phenol, 4,4'-butylidenebis[2-(1,1-dimethylethyl)-5-methyl-: ACTIVE

IT IS MADE BY MONSANTO CHEMICAL CO & SOLD UNDER TRADE NAME SANTOWHITE POWDER. IT IS PARTICULARLY RECOMMENDED FOR SYNTHETIC RUBBER... UP TO THE PRESENT SANTOWHITE POWDER HAS NOT BEEN AUTHORIZED FOR USE IN FOOD-PACKAGING FIELD.

AN ABSORBENT MAT IMPREGNATED WITH A COMPOSITION CONTAINING PYRETHROIDS & THE ANTIOXIDANT SANTOWHITE POWDER & ONE OR MORE OF ACETIC ACID ESTERS OF GLYCOL & THOSE OF GLYCOL MONOETHERS IS A FUMIGANT FOR COCKROACH CONTROL.