4-Aminoquinoline

HCID 68476
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Basic information

CAS
578-68-7
Standard SMILES
Nc1ccnc2ccccc12
InChIKey
FQYRLEXKXQRZDH-UHFFFAOYSA-N
Molecular formula
C9H8N2
Average molar mass
144.17 g/mol
Monoisotopic mass
144.06874826

Names & identifiers

Preferred name
4-Aminoquinoline
IUPAC
quinolin-4-amine
English name
4-Aminoguinoline
Molecular formula
C9H8N2
Molecular weight
144.17

Names & synonyms

4-Aminoquinoline578-68-74-QuinolinamineGTE5P5L97NDTXSID70206491RefChem:518302DTXCID70128982640-116-4quinolin-4-amine4-AminoguinolineQuinoline, 4-amino-MFCD00463448
Show more names
4(1H)-Quinolinimine4-Aminoquinoline 95+%4-Aminoquinoline ,98%4-Aminoquinoline, 97.5%
4-quinolylamine139266-00-5Quinolin-4-ylamineCCRIS 1679UNII-GTE5P5L97N4(1H)-Quinolinimine(9CI)4-quinolinylamine4-amino quinoline

Database identifiers

CAS
578-68-7
PubChem CID
68476
DTXSID
DTXSID70206491
ChEMBL
CHEMBL58146
UNII
GTE5P5L97N
EC Number
640-116-4
Nikkaji
J1.803.795E、J79.669G

Properties

Computed structural properties

XLogP
1.6
Topological polar surface area
38.9 Ų
Hydrogen bond donors
1
Hydrogen bond acceptors
2
Rotatable bonds
0
Heavy atoms
11

Physicochemical properties

Melting point
151 and · 151.0 and le 155.0 °C
Boiling point
312.78 °C · 312.78°C (estimate)
Density
1.1148 · 1.1148 (estimate)
refractive index
1.708 · 1.7080 (estimate)
storage temp.
Keep in dark place,Sealed in dry,Room Temperature
form
powder to crystalline

Safety & regulation

GHS classification

GHS Classification · 5 items

Warning

H302 (93%): Harmful if swallowed [Warning Acute toxicity, oral]；H315 (11.6%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

P264, P264+P265, P270, P280, P301+P317, P302+P352, P305+P351+P338, P321, P330, P332+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 43 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Hazard Classes and CategoriesAcute Tox. 4 (93%)；Skin Irrit. 2 (11.6%)；Eye Irrit. 2A (100%)

Safety data

wgk
WGK 3
ridadr
2811
hs_code
29334900
risk_code
20/21/22-36/37/38-36-22-41
Signal word
Warning
Symbol(GHS)
GHS07

Chemistry & industry

Pharmacology

MeSH Pharmacological ClassificationAgents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585)

Applications

Uses4-Quinolinamine and its derivatives are commonly used as anti-malarial drugs and also have potential therapeutic effects on patients afflicted with arthritis (and/or related diseases).

Preparation methods · 1 item

PreparationResearch has found that, under transition metal-free conditions, a series of 4-Aminoguinoline and their derivatives can be synthesized via a three-component one-pot method using amines, benzenesulfonyl acetonitrile, and dimethyl sulfoxide as substrates through catalytic oxidation cyclization reactions.

Upstream & downstream products

Suppliers100 total

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
郑州阿尔法化工有限公司+86-18530059196 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
毕佳索（上海毕得医药科技股份有限公司）400-6005915 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]

Related reactions

27 records
New reaction record

Compound notes

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