Basic information
- CAS
27912-14-7- Standard SMILES
CC(C)(C)NCC(O)COc1cccc2c1CCCC2=O.Cl- InChIKey
DNTDOBSIBZKFCP-UHFFFAOYSA-N- Molecular formula
- C17H26ClNO3
- Average molar mass
- 327.8 g/mol
- Monoisotopic mass
- 327.1601214
Overview
See also: Levobunolol (related).
Names & identifiers
- Preferred name
- Bunolol Hydrochloride
- IUPAC
- 5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-2H-naphthalen-1-one;hydrochloride
- English name
- Levobunolol hydrochloride
- Molecular formula
- C17H25NO3.ClH
- Molecular weight
- 327.85
Names & synonyms
Bunolol hydrochloride31969-05-8Bunolol HClW 6412AW0Q9J8634ZW-6412ARefChem:121914rac-Bunolol HydrochlorideBunolol hydrochloride [USAN]5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-2H-naphthalen-1-one;hydrochloridel-Bunolol hydrochlorideBunolol hydrochloride (USAN)
Show more names
LEVOBUNOLOL HCLAG-901w7000abetagangotensinvistagan(-)-rochloridl-bunololhydrochlorideLEVOBUNOLOL HYDROCHLORIDELevobunolol Hydrochloride (200 mg)
CCRIS 1062W 6421A; l-BunololSR-05000001735MirolBetaSiteUNII-W0Q9J8634Zrac-Bunolol HCl5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-2H-naphthalen-1-one;hydrochloride
Database identifiers
- CAS
27912-14-7、31969-05-8
Properties
Computed structural properties
- Topological polar surface area
- 58.6 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 6
- Heavy atoms
- 22
- Formal charge
- 0
- Complexity
- 350
Physicochemical properties
- Melting point
- 209 · 209-211°
- alpha
- 24589 · 24589 -19.6±0.7° (c = 2.90 in methanol)
- storage temp.
- Amber Vial, Refrigerator, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Sparingly)
- form
- Solid
- color
- White to Off-White
- Stability
- Light Sensitive
- FDA UNII
- 90 S49LDHH · O90S49LDHH
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 319 · H319-H302-H332-H312
- Precautionary statements
- 280 · P280-P302+P352-P312-P322-P363-P501-P264-P280-P305+P351+P338-P337+P313P-P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501
- HS Code
- 2922504500 · 2922504500
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Safety data
- hs_code
- 2922504500
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H319-H302-H332-H312
- Precautionary statements
- P280-P302+P352-P312-P322-P363-P501-P264-P280-P305+P351+P338-P337+P313P-P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.
Applications
DescriptionLevobunolol hydrochloride is a non-selective β-adrenergic blocker useful in the treatment of glaucoma. Worldwide, it represents the sixth B-blocker to be launched for this indication.
UsesAnti-adrenergic (β-receptor).
UsesA non-selective -adrenoceptor antagonist used as an anticonvulsant.
Upstream & downstream products
Upstream raw materials
Suppliers32 total
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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