Furagin
Basic information
- CAS
1672-88-4- Standard SMILES
O=C1CN(/N=C/C=C/c2ccc([N+](=O)[O-])o2)C(=O)N1- InChIKey
DECBQELQORZLLP-UAIOPKHMSA-N- Molecular formula
- C10H8N4O5
- Average molar mass
- 264.19 g/mol
- Monoisotopic mass
- 264.04946937
Overview
Nitrofuran derivative anti-infective agent used for urinary tract infections.
Names & identifiers
- Preferred name
- Furagin
- IUPAC
- 1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione
- English name
- Furazidine
- Molecular formula
- C10H8N4O5
- Molecular weight
- 264.19
Names & synonyms
FURAGINFurazidine1672-88-4FurazidinAkritoinFuraginumNF 4161-((3-(5-Nitro-2-furyl)allylidene)amino)hydantoin1-((3-(5-Nitro-2-furyl)allylidene)amino)-hydantoinK2R4N34Y9IDTXSID1010309082,4-Imidazolidinedione, 1-((3-(5-nitro-2-furanyl)-2-propenylidene)amino)-
Show more names
Furan pyridinef-35NF-416furanedineFuragin 99%Furagin/Furazidine
CHEBI:131714RefChem:141729DTXCID2015159731-((E)-((2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene)amino)imidazolidine-2,4-dione1-(3-(5-nitrofuran-2-yl)prop-2-enylideneamino)imidazolidine-2,4-dioneNF4161-(3-(5-Nitro-2-furyl)-N-2-propenylidine)amino-hydantoin1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione
Database identifiers
- CAS
1672-88-4- PubChem CID
- 6870646
- DTXSID
DTXSID101030908- ChEMBL
CHEMBL3707254- UNII
- K2R4N34Y9I
- EC Number
- 681-332-9
- Nikkaji
- J13.136I
Properties
Computed structural properties
- XLogP
- 0.5
- Topological polar surface area
- 121 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 3
- Heavy atoms
- 19
- Formal charge
- 0
- Complexity
- 455
Physicochemical properties
- Melting point
- 267 · 267-270°C (dec.)
- Density
- 1.61 · 1.61±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 7.79 · 7.79±0.10(Predicted)
- form
- Powder
- color
- Light yellow to yellow
- Stability
- Hygroscopic
- CAS DataBase Reference
- 1672 · 1672-88-4(CAS DataBase Reference)
- FDA UNII
- 2 R4N34Y9I · K2R4N34Y9I
- ATC code
- 1 XE03 · J01XE03
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 315 · H315-H319-H335
- Precautionary statements
- 261 · P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P313-P337+P313-P362-P403+P233-P405-P501
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (75%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 4 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Hazard Classes and CategoriesSkin Irrit. 2 (25%)
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H315-H319-H335
- Precautionary statements
- P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P313-P337+P313-P362-P403+P233-P405-P501
Chemistry & industry
Pharmacology
ATC Code
J - Antiinfectives for systemic use
QJ - Antiinfectives for systemic use
MeSH Pharmacological ClassificationSubstances capable of killing agents causing urinary tract infections or of preventing them from spreading.
Applications
UsesFuragin (a nitrofurantoin analog) has the same efficacy in treating acute cystitis as Ciprofloxacin, however the duration of therapy is longer. Antibacterial.
Additional notes
DefinitionChEBI: An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [3-(5-nitro-2-furyl)prop-2-en-1-ylidene]amino group (the configuration of the C2C and C2 bonds in the grouping that links the two heterocycles is not specified). A nitrofuran antibiotic with properties similar to nitrofurantoin, furagin is used in the treatment of urinary tract infections.
Related reactions
0 records
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Compound notes
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