Basic information
- CAS
58691-88-6- Standard SMILES
CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3C=C(C)C4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21C- InChIKey
KZUIYQJTUIACIG-YBZCJVABSA-N- Molecular formula
- C21H28O3
- Average molar mass
- 328.4 g/mol
- Monoisotopic mass
- 328.20384475
Overview
Nomegestrol is a corticosteroid hormone.
Names & identifiers
- Preferred name
- Nomegestrol
- IUPAC
- (8S,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,13-dimethyl-1,2,8,9,10,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
- English name
- Nomegestrol
- Molecular formula
- C21H28O3
- Molecular weight
- 328.45
Names & synonyms
Nomegestrol58691-88-6Nomegestrolum19-Norpregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-17-Hydroxy-6-methyl-19-nor-4,6-pregnadiene-3,20-dione10F89177CORefChem:854426G03DB04(1S,2R,10S,11S,14R,15S)-14-acetyl-14-hydroxy-8,15-dimethyltetracyclo(8.7.0.0^(2,7).0^(11,15))heptadeca-6,8-dien-5-one17-Hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dioneThermexMonaco
Show more names
NomegestrelNormegestrelNomesterolMELEGESTROL ACETATENOMEGESTROL ACETATENomegestrol USP/EP/BPNomegestrol###58691-88-6
(8S,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,13-dimethyl-1,2,8,9,10,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-oneNomegestrol (USAN/INN)Nomegestrol acetate impurity B CRSNomegestrol [INN]Nomegestrolum [Latin]Nomegestrol [USAN:INN:BAN]UNII-10F89177CODTXSID80866702
Database identifiers
Properties
Computed structural properties
- XLogP
- 2
- Topological polar surface area
- 54.4 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 1
- Heavy atoms
- 24
- Formal charge
- 0
- Complexity
- 673
Experimental & physicochemical properties
DrugsPharmaceuticals -> Listed in ZINC15
Physicochemical properties
- Boiling point
- 502.6 · 502.6±50.0 °C(Predicted)
- Density
- 1.17 · 1.17±0.1 g/cm3(Predicted)
- storage temp.
- 2 · 2-8°C
- solubility
- Chloroform: soluble,DMSO: slightly soluble,Methanol: slightly soluble
- form
- A solid
- pka
- 12.99 · 12.99±0.60(Predicted)
- FDA UNII
- 10 F89177CO · 10F89177CO
- ATC code
- 3 DB04 · G03DB04
- Symbol(GHS)
- 8 · GHS08,GHS09
- Signal word
- Warning
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS08,GHS09
Chemistry & industry
Pharmacology
ATC Code
G - Genito urinary system and sex hormones
QG - Genito urinary system and sex hormones
Applications
DescriptionNomegestrol acetate is the 19-nor derivative of megestrol acetate, useful in the treatment of gynecological conditions associated with luteal deficiency.
DescriptionNomegestrol is a derivative of 19-norprogesterone. It increases nuclear levels of the progesterone receptor in rat uterus when administered at a dose of 1 mg/animal.
UsesA progestogen, derivatives of which are used in contraceptives and hormone therapies.
UsesProgetin used in implantable hormone replacement therapies.
General DescriptionNomegestrol acetate, 17-hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione acetate,is being investigated as the progestin component of anew oral contraceptive, in combination with the estrogenestradiol. This new combination, NOMAC/E2, is in phaseIII trials and would be the first oral contraceptive to utilizeestradiol itself as the estrogenic component. Structurally,NOMAC is considered a nor-progesterone derivative thatlacks the C19 methyl group in megestrol acetate.
Suppliers62 total
咸宁深蓝生物医药研发有限公司18171815831 · [email protected]
湖北金梭生物科技有限公司00123456789 · [email protected]
湖北海克斯生化有限公司17362916295; 17362916295 · [email protected]
湖北科乐精细化工有限公司027-59101668 19945030958 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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