Basic information
- CAS
58712-69-9- Standard SMILES
O=c1c2cccnc2oc2c(Cl)cc(-c3nn[nH]n3)cc12- InChIKey
MLCGWPUVZKTVLO-UHFFFAOYSA-N- Molecular formula
- C13H6ClN5O2
- Average molar mass
- 299.67 g/mol
- Monoisotopic mass
- 299.0210021
Overview
Traxanox is a pyridochromene.
Names & identifiers
- Preferred name
- Traxanox
- IUPAC
- 9-chloro-7-(2H-tetrazol-5-yl)chromeno[2,3-b]pyridin-5-one
- English name
- Traxanox
- Molecular formula
- C13H6ClN5O2
- Molecular weight
- 299.67
Names & synonyms
Traxanox58712-69-9HDU53A8A4S9-Chloro-5-oxo-7-(1H-tetrazol-5-yl)-5H-(1)benzopyrano(2,3-b)pyridineDTXSID50207421RefChem:190697DTXCID50129912Y-12,141Traxanox [INN]9-chloro-7-(2H-tetrazol-5-yl)chromeno[2,3-b]pyridin-5-oneTraxanoxumTraxanoxum [INN-Latin]
Show more names
5H-[1]Benzopyrano[2,3-b]pyridin-5-one, 9-chloro-7-(2H-tetrazol-5-yl)-
UNII-HDU53A8A4STRAXANOX [MI]9-Chloro-7-(1H-tetrazol-5-yl)-5H-(1)benzopyrano(2,3-b)pyridin-5-oneSCHEMBL29628orb1819138SCHEMBL1649807CHEMBL2009696CHEBI:135269
Database identifiers
- CAS
58712-69-9- PubChem CID
- 68784
- DTXSID
DTXSID50207421- ChEMBL
CHEMBL2009696- ChEBI
CHEBI:135269- UNII
- HDU53A8A4S
- Nikkaji
- J13.846K
Properties
Computed structural properties
- XLogP
- 2.1
- Topological polar surface area
- 93.7 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 1
- Heavy atoms
- 21
- Formal charge
- 0
- Complexity
- 425
Physicochemical properties
- Melting point
- 300 ° · >300°
- FDA UNII
- 53 A8A4S · HDU53A8A4S
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319-H335
- Precautionary statements
- 280 · P280-P305+P351+P338
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P280-P305+P351+P338
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Agents that promote the excretion of urine through their effects on kidney function.
Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Gout suppressants that act directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma.
Applications
UsesTraxanox is an orally available diuretic that enhances phagocytosis of yeast granules by mouse peritoneal macrophages and rat peritoneal polymorphonuclear leukocytes in vitro. Traxanox inhibits IgE-mediated histamine release and cyclic AMP phosphodiesterase activity.Traxanox exhibits anti-inflammatory activity, as it inhibits the anaphylactoid reaction and reduces pleural fluid accumulation in experimental models of inflammation. Traxanox also demonstrates a synergistic effect when combined with hydrocortisone or indomethacin in suppressing adjuvant arthritis in rats.
Suppliers4 total
北京博奥森生物技术有限公司400-901-9800 18611424007 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
Related reactions
0 records
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Compound notes
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