Basic information
- CAS
63394-05-8- Standard SMILES
CC(C)(Oc1ccc(Cl)cc1)C(=O)NC(=O)NCN1CCOCC1- InChIKey
DDDQVDIPBFGVIG-UHFFFAOYSA-N- Molecular formula
- C16H22ClN3O4
- Average molar mass
- 355.81 g/mol
- Monoisotopic mass
- 355.1298839
Overview
Plafibride is an aromatic ether.
Names & identifiers
- Preferred name
- Plafibride
- IUPAC
- 2-(4-chlorophenoxy)-2-methyl-N-(morpholin-4-ylmethylcarbamoyl)propanamide
- English name
- plafibride
- Molecular formula
- C16H22ClN3O4
- Molecular weight
- 355.82
Names & synonyms
Plafibride63394-05-8PlafibridaPlafibridumIta 1042-CIMMU5J7C4JZ564DTXSID1023491RefChem:174666DTXCID203491N-(2-(4-Chlorophenoxy)isobutyryl)-N-morpholinomethylurea264-121-2
Show more names
Brn 0569805Einecs 264-121-2N-2(p-Chlorophenoxy)isobutyryl-N'-morpholinomethylureaN'-Morpholinomethylurea, N-2-(p-chlorophenoxy)isobutyryl-N-2(p-Chlorophenoxy)-2-methylpropionyl-N'-morpholinomethylurea
Plafibride [INN]ITA-1042-(4-chlorophenoxy)-2-methyl-N-(morpholin-4-ylmethylcarbamoyl)propanamideIdonorITA 104; Idonor; PerifunalPerifunalPlafibrida [Spanish]Plafibridum [INN-Latin]
Database identifiers
- CAS
63394-05-8、67924-59-8- PubChem CID
- 68822
- DTXSID
DTXSID1023491- ChEMBL
CHEMBL2107129- ChEBI
CHEBI:135503
Properties
Computed structural properties
- XLogP
- 2.4
- Topological polar surface area
- 79.9 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 5
- Heavy atoms
- 24
- Formal charge
- 0
- Complexity
- 433
Physicochemical properties
- Melting point
- 100 · 100-102°
- Density
- 1.3022 · 1.3022 (rough estimate)
- refractive index
- 1.68 · 1.6800 (estimate)
- FDA UNII
- 5 J7C4JZ564 · 5J7C4JZ564
- Toxicity
- 50 in · LD50 in mice, rats, guinea pigs (mg/kg): 3569, >4000, 2168 orally (Zapatero, Brugeghini)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Toxicity
- LD50 in mice, rats, guinea pigs (mg/kg): 3569, >4000, 2168 orally (Zapatero, Brugeghini)
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS.
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
Applications
UsesPlafibride (ITA 104) is an orally active hypolipemic, platelet aggregation inhibitor[1][2].
Upstream & downstream products
Downstream products
Suppliers3 total
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
Additional notes
DefinitionChEBI: Plafibride is an aromatic ether.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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