Basic information
- CAS
99291-24-4- Standard SMILES
OC[C@H](O)CN1CCN(c2ccccc2)CC1- InChIKey
PTVWPYVOOKLBCG-CYBMUJFWSA-N- Molecular formula
- C13H20N2O2
- Average molar mass
- 236.31 g/mol
- Monoisotopic mass
- 236.15247789
Names & identifiers
- Preferred name
- (2R)-3-(4-Phenylpiperazin-1-yl)propane-1,2-diol
- IUPAC
- (2R)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol
- English name
- (R)-(+)-Dropropizine
- Molecular formula
- C13H20N2O2
- Molecular weight
- 236.31
Names & synonyms
(2R)-3-(4-phenylpiperazin-1-yl)propane-1,2-diolRefChem:397319110-905-399291-24-4(+)-Dropropizine(R)-(+)-Dropropizine(R)-3-(4-Phenylpiperazin-1-yl)propane-1,2-diolDextrodropropizineDropropizine S-form1,2-Propanediol, 3-(4-phenyl-1-piperazinyl)-, (R)-FS5K818KA7Levdropropizina [Latin,Spanish]
Show more names
LevodropropizineLevdropropizina(S)-DropropizineLevodropropizine API
(R)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediolBRN 3592398UNII-FS5K818KA7Levodropropizine EP Impurity ALevodropropizine impurity A; (2R)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol; DextrodropropizineD-DROPROPIZINE(2R)-3-(4-phenyl-1-piperazinyl)propane-1,2-diolDROPROPIZINE, (R)-
Database identifiers
- CAS
99291-24-4- PubChem CID
- 688451
- DTXSID
DTXSID101030215- UNII
- FS5K818KA7
- EC Number
- 110-905-3
- Nikkaji
- J1.459.111G
Properties
Computed structural properties
- XLogP
- 0.6
- Topological polar surface area
- 46.9 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 4
- Heavy atoms
- 17
- Formal charge
- 0
- Complexity
- 211
Physicochemical properties
- Melting point
- 98 · 98-100°
- alpha
- 25 · D25 -10° (c = 1.0 in ethanol)
- Boiling point
- 412.7 · 412.7±34.0 °C(Predicted)
- Density
- 1.168 · 1.168±0.06 g/cm3(Predicted)
- storage temp.
- 2 · 2-8°C
- solubility
- Acetonitrile (Slightly), Methanol (Slightly)
- pka
- 14.21 · 14.21±0.20(Predicted)
- color
- White to Off-White
- Major Application
- pharmaceutical (small molecule)
- InChI
- 1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2/t13-/m1/s1
- InChIKey
- PTVWPYVOOKLBCG-CYBMUJFWSA-N
- SMILES
- N1(CCN(CC1)c2ccccc2)C[C@@H](O)CO
- CAS DataBase Reference
- 99291 · 99291-24-4(CAS DataBase Reference)
- EWG's Food Scores
- 1 · 1
- FDA UNII
- 5 K818KA7 · FS5K818KA7
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Hazard information
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Safety data
- wgk
- WGK 3
- Toxicity
- LD50 in mice, rats (mg/kg): 1287.2, 886.6 orally; 408.0, 401.3 i.p. (Borsa)
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H302
- Hazard Classifications
- Acute Tox. 4 Oral
- Precautionary statements
- P264-P270-P301+P312-P501
Chemistry & industry
Applications
DescriptionLevodropropizine is an antitussive with antiinflammatory activity, the L-isomer of dropropizine. Compared with the racemate, levodropropizine is reported to have less sedative potential and better therapeutic index, while maintaining the the same efficacy levels as an antitussive and antiinflammatory.
Usesreceptor agonist, treatment of colds and allergic rhinitis
UsesR-Form of Dropropizine (D681495). (R)-(+)-Dropropizine is a cough suppressive phenylpiperazine derivative. (R)-(+)-Dropropizine is an antitussive and central sedative therapeutic agent.
Suppliers57 total
北京华美互利生物化工010-56205725 · [email protected]
广州佳途科技股份有限公司81960175-877 18933936954 · [email protected]
江苏艾康生物医药研发有限公司025-66061636 19370895928 · [email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
上海迈瑞尔生化科技有限公司4006356688 18621169109 · [email protected]
湖北威德利化学试剂有限公司17771473825 13385289472 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
上海恩诺生物科技有限公司+86 (21) 6435-5022
天津万象恒远科技有限公司15722085254 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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