Basic information
- CAS
66529-17-7- Standard SMILES
c1ccc(C(CC2=NCCN2)c2ccccn2)cc1- InChIKey
TYZQFNOLWJGHRZ-UHFFFAOYSA-N- Molecular formula
- C16H17N3
- Average molar mass
- 251.33 g/mol
- Monoisotopic mass
- 251.14224756
Overview
orally effective hypoglycemic agent structurally unrelated to known hypoglycemics; RN given for parent cpd
Names & identifiers
- Preferred name
- Midaglizole
- IUPAC
- 2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenylethyl]pyridine
- English name
- Midaglizole
- Molecular formula
- C16H17N3
- Molecular weight
- 251.33
Names & synonyms
Midaglizole66529-17-7MidaglizolMidaglizolum44NWV6A237RefChem:158826Midaglizole [INN]2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenylethyl]pyridineMidaglizol [Spanish]Midaglizolum [Latin]UNII-44NWV6A237MIDAGLIZOLE [MART.]
Show more names
DG-5128DG5128 free base2-[2-(2-Imidazolin-2-yl)-1-phenylethyl]pyridine4,5-Dihydro-2-[2-(2-pyridinyl)-2-phenylethyl]-1H-imidazolePyridine, 2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenylethyl]-(±)-DG5128 free base|||DG5128 free base|||(±)-DG5128 free base
CHEMBL40611SCHEMBL114554orb1745187SCHEMBL30029057(+-)-2-(alpha-(2-Imidazolin-2-ylmethyl)benzyl)pyridineDTXSID30867229MS-23556DB-089435
Database identifiers
- CAS
66529-17-7- PubChem CID
- 68864
- DTXSID
DTXSID30867229- ChEMBL
Properties
Computed structural properties
- XLogP
- 1.5
- Topological polar surface area
- 37.3 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 4
- Heavy atoms
- 19
- Formal charge
- 0
- Complexity
- 307
Physicochemical properties
- storage temp.
- -20 °C · Store at -20°C
- form
- Solid
- color
- White to off-white
- FDA UNII
- 44 NWV6A237 · 44NWV6A237
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
Substances which lower blood glucose levels.
Applications
UsesMidaglizole ((±)-DG5128 free base, DG5128 free base) is a potent α2-adrenoceptor antagonist. Midaglizole is a hypoglycemic agent. Midaglizole increases blood pressure and reduces blood glucose levels in vivo[1][2][3].
Suppliers3 total
上海陶术生物科技股份有限公司13564774135 · [email protected]
天津凯利奇生物科技有限公司15076683720 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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