Basic information
- CAS
68206-94-0- Standard SMILES
CCOC(=O)COc1ccc2c(C)c(CCN(CC)CC)c(=O)oc2c1Cl- InChIKey
GYNNRVJJLAVVTQ-UHFFFAOYSA-N- Molecular formula
- C20H26ClNO5
- Average molar mass
- 395.9 g/mol
- Monoisotopic mass
- 395.1499506
Overview
Cloricromen is a member of coumarins.
Names & identifiers
- Preferred name
- Cloricromen
- IUPAC
- ethyl 2-[8-chloro-3-[2-(diethylamino)ethyl]-4-methyl-2-oxochromen-7-yl]oxyacetate
- English name
- Cloricromene
- Molecular formula
- C20H26ClNO5
- Molecular weight
- 395.88
Names & synonyms
CloricromenCloricromene68206-94-08-ChlorocarbochromenCloricromenoCloricromenumB9454PE93CAcetic acid, ((8-chloro-3-(2-(diethylamino)ethyl)-4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy)-, ethyl esterDTXSID2048373ethyl 2-((8-chloro-3-(2-(diethylamino)ethyl)-4-methyl-2-oxo-2H-chromen-7-yl)oxy)acetateRefChem:1270988-chloro-3-beta-diethylaminoethyl-4-methyl-7-ethyoxycarbonymethoxycoumarin
Show more names
Cromocapad6(pharmaceutical)Cloricromene USP/EP/BPO=C(OCC)COC1=CC=C(C(O2)=C1Cl)C(C)=C(CCN(CC)CC)C2=Oaceticacid,((8-chloro-3-(2-(diethylamino)ethyl)-4-methyl-2-oxo-2h-1-benzopyraEthyl 2-[8-chloro-3-(2-diethylaminoethyl)-4-methyl-2-oxochromen-7-yl]oxyacetate
8-monochloro-3-beta-diethylaminoethyl-4-methyl-7-ethoxycarboxylmethoxycoumarinDTXCID8028347B01AC02636-182-9Cloricromen [INN]ProendotelAD-6Cloricromen (INN)
Properties
Computed structural properties
- XLogP
- 3.8
- Topological polar surface area
- 65.1 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 10
- Heavy atoms
- 27
- Formal charge
- 0
- Complexity
- 561
Physicochemical properties
- Melting point
- 221 · 221-222.3 °C
- storage temp.
- 2 · 2-8°C
- solubility
- 17 mg/mL · DMSO: 17 mg/mL
- form
- solid
- color
- white
- FDA UNII
- 9454 PE93C · B9454PE93C
- ATC code
- 1 AC02 · B01AC02
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302
- Precautionary statements
- 264 · P264-P270-P301+P312-P330-P501
- Hazard Codes
- Xn
- Risk Statements
- 22 · 22
- WGK Germany
- 3 · 3
- RTECS
- 8970000 · AF8970000
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 39 reports by companies from 1 notifications to the ECHA C&L Inventory.
Hazard information
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Safety data
- wgk
- 3
- rtecs
- AF8970000
- risk_code
- 22
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xn
- Hazard statements
- H302
- Precautionary statements
- P264-P270-P301+P312-P330-P501
Chemistry & industry
Pharmacology
ATC Code
B - Blood and blood forming organs
QB - Blood and blood forming organs
MeSH Pharmacological Classification
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
Applications
DescriptionCloricromen is a new coumarin derivative useful as a coronary vasodilator and antithrombotic. It differs from existing antithrombotic agents in that it does not act chiefly on platelets. Cloricromen is reportedly well tolerated, improves exercise tolerance and decreases usage of nitrates by angina patients.
Upstream & downstream products
Upstream raw materials
Suppliers13 total
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…