Basic information
- CAS
71522-58-2- Standard SMILES
N[C@H](C(=O)O)c1ccc(CO)c(O)c1- InChIKey
JRBXPUUAYKCCLQ-QMMMGPOBSA-N- Molecular formula
- C9H11NO4
- Average molar mass
- 197.19 g/mol
- Monoisotopic mass
- 197.06880783
Overview
Forfenimex is a small molecule drug. Forfenimex has a monoisotopic molecular weight of 197.07 Da.
Names & identifiers
- Preferred name
- (alphaS)-alpha-Amino-3-hydroxy-4-(hydroxymethyl)benzeneacetic acid
- IUPAC
- (2S)-2-amino-2-[3-hydroxy-4-(hydroxymethyl)phenyl]acetic acid
- English name
- forphenicinol
- Molecular formula
- C9H11NO4
- Molecular weight
- 197.189
Names & synonyms
Forfenimex71522-58-2ForfenimexumEL461OY152DTXSID10221764RefChem:1050798DTXCID40144255(alphaS)-alpha-Amino-3-hydroxy-4-(hydroxymethyl)benzeneacetic acidForphenicinolForfenimex [INN](2S)-2-amino-2-[3-hydroxy-4-(hydroxymethyl)phenyl]acetic acid(+)-(S)-2-(alpha,3-Dihydroxy-p-tolyl)glycine
Show more names
BF121BF-121α-Amino-3-hydroxy-4-(hydroxymethyl)benzeneacetic acidBenzeneacetic acid, α-amino-3-hydroxy-4-(hydroxymethyl)-, (αS)-
2-AMINO-2-[3-HYDROXY-4-(HYDROXYMETHYL)PHENYL]ACETIC ACIDMFCD22525860Forfenimexum [Latin]Forfenimexa [Spanish]Forfenimexa(S)-2-Amino-2-(3-hydroxy-4-(hydroxymethyl)phenyl)acetic acidBF 121BRN 5003730
Database identifiers
- CAS
71522-58-2- PubChem CID
- 68908
- DTXSID
DTXSID10221764
Properties
Computed structural properties
- XLogP
- -2.4
- Topological polar surface area
- 104 Ų
- Hydrogen bond donors
- 4
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 3
- Heavy atoms
- 14
- Formal charge
- 0
- Complexity
- 209
Experimental & physicochemical properties
DrugsPharmaceuticals -> Antibiotics
Physicochemical properties
- Boiling point
- 334.28 °C · 334.28°C (rough estimate)
- Density
- 1.3075 · 1.3075 (rough estimate)
- refractive index
- 1.527 · 1.5270 (estimate)
- storage temp.
- -20 °C · -20°C
- solubility
- DMSO: soluble,Methanol: soluble,
- form
- A solid
- Water Solubility
- Water: soluble
- EWG's Food Scores
- 1 · 1
- FDA UNII
- 461 OY152 · EL461OY152
Chemistry & industry
Applications
UsesForphenicinol is an immunomodulator and a derivative of the bacterial metabolite forphenicine. It increases the phagocytosis of yeast by peritoneal macrophages isolated from thioglycolate-stimulated mice. Forphenicinol (100 μg/animal) prevents cyclophosphamide-induced suppression of delayed-type hypersensitivity (DTH), as well as enhances DTH in response to the hapten oxazolone or sheep red blood cells in mice. It enhances the bactericidal activity of macrophages against P. aeruginosa in mice when administered at a dose of 0.5 mg/kg.2 Forphenicinol (15.6-1,000 μg/animal) increases survival in a mouse model of P. aeruginosa infection. It also inhibits tumor growth in S180 sarcoma and IMC carcinoma mouse xenograft models when administered at doses ranging from 0.05 to 5 mg/kg per day.
Suppliers8 total
上海安化生物技术有限公司021-61263375 18168859245
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
滨海吉尔多肽有限公司021-61263389 13524856427 · [email protected]
无锡迈默拓普生物科技有限公司15061806929 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354 · [email protected]
山东子易医药有限公司13173053288 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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