Basic information
- CAS
71653-63-9- Standard SMILES
COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1OC(F)F- InChIKey
AZVFIZVKGSPGPK-UHFFFAOYSA-N- Molecular formula
- C18H19F2NO5
- Average molar mass
- 367.3 g/mol
- Monoisotopic mass
- 367.12312903
Overview
Riodipine is a small molecule drug. The usage of the INN stem '-dipine' in the name indicates that Riodipine is a calcium channel blocker, nifedipine derivative. Riodipine has a monoisotopic molecular weight of 367.12 Da.
Names & identifiers
- Preferred name
- Riodipine
- IUPAC
- dimethyl 4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- English name
- Riodipine
- Molecular formula
- C18H19F2NO5
- Molecular weight
- 367.346
Names & synonyms
RiodipineRyodipine71653-63-9ForidonRiodipinoRiodipinumDTXSID5046148W12VDB26LBDTXCID3026148RefChem:1794812,6-dimethyl-3,5-dimethoxycarbonyl-4-(O-difluoromethoxy)phenyl-1,4-dihydropyridineRiodipine [INN]
Show more names
dimethyl 4-(2-(difluoromethoxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylatedimethyl 4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate3,5-Pyridinedicarboxylic acid, 4-[2-(difluoromethoxy)phenyl]-1,4-dihydro-2,6-dimethyl-, 3,5-dimethyl ester
PP-1466Foridon; PP-1466;dimethyl 4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate3,5-dimethyl 4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylateCHEMBL347573NCGC00160435-01Riodipinum [Latin]Riodipino [Spanish]
Database identifiers
- CAS
71653-63-9- PubChem CID
- 68909
- DTXSID
DTXSID5046148
Properties
Computed structural properties
- XLogP
- 3.3
- Topological polar surface area
- 73.9 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 8
- Rotatable bonds
- 7
- Heavy atoms
- 26
- Formal charge
- 0
- Complexity
- 591
Physicochemical properties
- Melting point
- 157 °C · 157°C
- Boiling point
- 445.4 · 445.4±45.0 °C(Predicted)
- Density
- 1.2786 · 1.2786 (estimate)
- pka
- 2.9 · 2.90±0.70(Predicted)
- FDA UNII
- 12 VDB26LB · W12VDB26LB
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319-H335
- Precautionary statements
- 280 · P280-P305+P351+P338
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P280-P305+P351+P338
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Drugs used to prevent SEIZURES or reduce their severity.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
A class of drugs that act by selective inhibition of calcium influx through cellular membranes.
Drugs used to cause dilation of the blood vessels.
Applications
UsesReplenisher (fluid); replenisher (electrolyte).
Suppliers4 total
天津荣燊化工有限公司18317763565; 18317763565 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…