Glycinamide (HCID 69020)

Overview

Glycinamide is an amino acid amide and a glycine derivative.

Names & identifiers

Preferred name: Glycinamide
IUPAC: 2-aminoacetamide
English name: Glycinamide hydrochloride
Molecular formula: C2H7ClN2O
Molecular weight: 110.54

Names & synonyms

Glycinamide2-Aminoacetamide598-41-4Glycine amideAcetamide, 2-amino-AMINOMETHYLAMIDE4JDT453NWODTXSID1060508CHEBI:42843RefChem:663618DTXCID4042701209-932-4

Show more names

2-AMINOACETAMIDE HYDROCHLORIDEGLYCINAMIDE HCLGLYCINE AMIDE HYDROCHLORIDEAminoacetamide hydrochlorideGly-Nh2.HclGLYCINAMIDE HCIGly-NH2.HCIH-GLY-NH2 HCLGLYCINE-NH2 HCLGlycineamide HCl

GLYCINAMIDPiracetam Impurity 112-Amino-AcetamideMFCD018597152-Aminoacetimidic acid4463-18-7aminoacetamideUNII-4JDT453NWO

Database identifiers

CAS: 1668-10-6、598-41-4
PubChem CID: 69020
DTXSID: DTXSID1060508
ChEMBL: CHEMBL86954
ChEBI: CHEBI:42843
UNII: 4JDT453NWO
EC Number: 209-932-4
Nikkaji: J2.716B

Properties

Computed structural properties

XLogP: -1.8
Topological polar surface area: 69.1 Å²
Hydrogen bond donors: 2
Hydrogen bond acceptors: 2
Rotatable bonds: 1
Heavy atoms: 5
Formal charge: 0
Complexity: 42.9

Experimental & physicochemical properties

DrugsPharmaceuticals -> Listed in ZINC15

SpringerMaterials PropertiesChemical shift

Physicochemical properties

Melting point: 204 °C · 204 °C (dec.)(lit.)
storage temp.: Inert atmosphere,Room Temperature
solubility: 2 O: · H2O: 0.1 g/mL, clear
form: Crystalline Powder
color: White to beige
pka: 8.2 · 8.20(at 20℃)
Water Solubility: Soluble in water (1100g/L).
Sensitive: Hygroscopic
λmax: 260 nm · λ: 260 nm Amax: 0.1
BRN: 3554199 · 3554199
Stability: Hygroscopic
Cosmetics Ingredients Functions: SKIN PROTECTINGSKIN CONDITIONING
InChI: InChI=1S/C2H6N2O.ClH/c3-1-2(4)5;/h1,3H2,(H2,4,5);1H
InChIKey: WKNMKGVLOWGGOU-UHFFFAOYSA-N
SMILES: C(=O)(N)CN.Cl
CAS DataBase Reference: 1668 · 1668-10-6(CAS DataBase Reference)
FDA UNII: 9 SPG4KUG6A · 9SPG4KUG6A
UNSPSC Code: 12352100 · 12352100
NACRES: 22 · NA.22
Symbol(GHS): 7 · GHS07
Signal word: Warning
Hazard statements: 302 · H302-H315-H319-H332-H335
Precautionary statements: 261 · P261-P280-P305+P351+P338
PPE: 95 · Eyeshields, Gloves, type N95 (US)
Hazard Codes: Xi
Risk Statements: 36 · 36/37/38
Safety Statements: 22 · 22-24/25-37/39-26
WGK Germany: 3 · 3
F: 3 · 3-10
HazardClass: IRRITANT
HS Code: 29241900 · 29241900
Storage Class: 11 · 11 - Combustible Solids

Safety & regulation

Safety data

F: 3-10
PPE: Eyeshields, Gloves, type N95 (US)
wgk: 3
hs_code: 29241900
risk_code: 36/37/38
Signal word: Warning
Symbol(GHS): GHS07
hazard_code: Xi
safety_code: 22-24/25-37/39-26
hazard_class: IRRITANT
Storage Class: 11 - Combustible Solids
Hazard statements: H302-H315-H319-H332-H335
Precautionary statements: P261-P280-P305+P351+P338

Chemistry & industry

Uses & manufacturing

General Manufacturing InformationAcetamide, 2-amino-: INACTIVE

Applications · 2 items

UsesGlycinamide hydrochloride is a buffer that is useful in the physiological pH range. And it is also used as a pharmaceutical intermediate, in the organic synthesis.

UsesGlycinamide hydrochloride may be used in the synthesis of [M(glycinamidato-N,N′)(ptpy)2] where ptpy = 2-(p-tolyl)pyridinato) and M= Rh or Ir. It may be used in the synthesis of the following glycinamide-based imidazolidinones:(±)-2-(2-phenylpropyl)imidazolidin-4-one(±)-2-(2,4,4-trimethylpentyl)imidazolidin-4-one (±)-2-[(R)-2,6-dimethyl-5-heptenyl]imidazolidin-4-one (5R,6S,9R)-6-isopropyl-9-methyl-1,4-diazaspiro[4.5]decan-2-one(5S,6S,9R)-6-isopropyl-9-methyl-1,4-diazaspiro[4.5]decan-2-one(±)-2-methyl-2-pentylimidazolidin-4-one(±)-2-ethyl-2-(2-methylbutyl)imidazolidin-4-one (±)-2-(undecan-2-yl)imidazolidin-4-one (±)-2-pentylimidazolidin-4-one 2-(2,4-dimethylcyclohex-3-en-1-yl)imidazolidin-4-one