2-Nitro-1-naphthol

HCID 69083

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Basic information

CAS: 607-24-9
Standard SMILES: O=[N+]([O-])c1ccc2ccccc2c1O
InChIKey: MUCCHGOWMZTLHK-UHFFFAOYSA-N
Molecular formula: C10H7NO3
Average molar mass: 189.17 g/mol
Monoisotopic mass: 189.04259309

Names & identifiers

Preferred name: 2-Nitro-1-naphthol
IUPAC: 2-nitronaphthalen-1-ol
English name: 2-Nitro-1-naphthol
Molecular formula: C10H7NO3
Molecular weight: 189.17

Names & synonyms

2-Nitro-1-naphtholDTXSID70209508EINECS 210-131-7NSC 43140RefChem:477136DTXCID50131999210-131-7607-24-92-nitronaphthalen-1-olMFCD00003956nitronaphthol1-Naphthol, 2-nitro-

Show more names

2-Nitro-1-Napthol2-Nitro-2-naphthol2-Nitro-1-naphthol 95%2-Nitro-1-naphthol,98%(S)-1-[()-2-(di-tert.-Butylphosphino)ferrocenylethylbis(2-

2-Nitronaphth-1-olSKE3TA8XGHNSC43140NSC-431402-Nitro-naphthalen-1-ol1-Naphthalenol, 2-nitro-2-nitronaphtholMUCCHGOWMZTLHK-UHFFFAOYSA-

Database identifiers

CAS: 607-24-9
PubChem CID: 69083
DTXSID: DTXSID70209508
UNII: SKE3TA8XGH
EC Number: 210-131-7
Nikkaji: J95.058K

Properties

Computed structural properties

XLogP: 2.9
Topological polar surface area: 66.1 Å²
Hydrogen bond donors: 1
Hydrogen bond acceptors: 3
Rotatable bonds: 0
Heavy atoms: 14
Formal charge: 0
Complexity: 226

Physicochemical properties

Melting point: 123 · 123-125 °C (lit.)
Boiling point: 324.41 °C · 324.41°C (rough estimate)
Density: 1.3175 · 1.3175 (rough estimate)
refractive index: 1.54 · 1.5400 (estimate)
storage temp.: Sealed in dry,Room Temperature
form: Powder
pka: 6.13 · 6.13±0.50(Predicted)
Appearance: Light yellow to yellow Solid
InChI: InChI=1S/C10H7NO3/c12-10-8-4-2-1-3-7(8)5-6-9(10)11(13)14/h1-6,12H
InChIKey: MUCCHGOWMZTLHK-UHFFFAOYSA-N
SMILES: C1(O)=C2C(C=CC=C2)=CC=C1[N+]([O-])=O
CAS DataBase Reference: 607 · 607-24-9(CAS DataBase Reference)
FDA UNII: 3 TA8XGH · SKE3TA8XGH
NIST Chemistry Reference: 2 · 2-Nitro-1-naphthol(607-24-9)
UNSPSC Code: 12352100 · 12352100
NACRES: 22 · NA.22
Symbol(GHS): 7 · GHS07
Signal word: Warning
Hazard statements: 315 · H315-H319-H335
Precautionary statements: 261 · P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs: Respiratory system
PPE: 95 · dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes: Xi
Risk Statements: 36 · 36/37/38
Safety Statements: 26 · 26-37/39-24/25-36
WGK Germany: 3 · 3
Hazard Note: Irritant
HS Code: 29089990 · 29089990
Storage Class: 11 · 11 - Combustible Solids
Hazard Classifications: 2 Skin · Eye Irrit. 2Skin Irrit. 2STOT SE 3

Safety & regulation

Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.

GHS classification

GHS Classification · 4 items

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 40 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Hazard Classes and CategoriesSkin Irrit. 2 (100%)

Safety data

PPE: dust mask type N95 (US), Eyeshields, Gloves
wgk: 3
hs_code: 29089990
risk_code: 36/37/38
Signal word: Warning
Symbol(GHS): GHS07
hazard_code: Xi
hazard_note: Irritant
safety_code: 26-37/39-24/25-36
Storage Class: 11 - Combustible Solids
target organs: Respiratory system
Hazard statements: H315-H319-H335
Hazard Classifications: Eye Irrit. 2Skin Irrit. 2STOT SE 3
Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338

Chemistry & industry

Applications · 2 items

Description2-Nitro-1-naphthol is an important organic compound with anti-inflammatory properties used as an analytical method for measuring albumin concentration and as an enzyme-labelled substrate in electrochemical immunoassays. The substance reacts with albumin to form a coloured complex which can be detected spectrophotometrically. It is also used as a model system for the study of inflammatory diseases and inhibits p38 kinase activity. In addition, a derivative of 2-Nitro-1-naphthol (4-nitro-1-naphthol) can be used to prepare chromogenic substrates for neutral or slightly acidic hydrolases.

Uses2-Nitro-1-naphthol was employed as substrate for use in an amperometric 3-electrode system for the determination of alkaline phosphatase, the enzyme label most commonly used in electrochemical immunoassays. It was also used in the preparation of:di-(2-nitro-1-naphthyl) hydrogen phosphate1-(2′-methyl-3′-indenyl)-2-naphthylamine and -2-naphthol (axially chiral ligands)

Upstream & downstream products

Upstream raw materials

2-Nitroso-1-naphthol

Downstream products

1-bromo-2-nitronaphthalene 2-Amino-1-naphthylhydrogensulphate

Suppliers100 total

郑州阿尔法化工有限公司+86-18530059196 · [email protected]

衢州润东化工有限公司0570-8789886 18892685668 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

湖北万得化工有限公司15377098680 15377098680 · [email protected]

毕佳索（上海毕得医药科技股份有限公司）400-6005915 · [email protected]

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