Basic information
- CAS
58934-46-6- Standard SMILES
CC(C)N1CCC(N(C(=O)Cc2ccccc2)c2ccc(Cl)cc2)CC1.Cl- InChIKey
FSFSWNBDCJVFGI-UHFFFAOYSA-N- Molecular formula
- C22H28Cl2N2O
- Average molar mass
- 407.4 g/mol
- Monoisotopic mass
- 406.15786888
Overview
See also: Lorcainide (has active moiety).
Names & identifiers
- Preferred name
- Lorcainide Hydrochloride
- IUPAC
- N-(4-chlorophenyl)-2-phenyl-N-(1-propan-2-ylpiperidin-4-yl)acetamide;hydrochloride
- English name
- N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride
- Molecular formula
- C22H28Cl2N2O
- Molecular weight
- 407.37652
Names & synonyms
Lorcainide hydrochloride58934-46-6Lorcainide HClSocainide hydrochlorideRemivoxIsocainide hydrochlorideLopantrolLorivoxNSC-310411Lorcainide hydrochloride [USAN]R-15889Lorcainida clorhidrato
Show more names
Nsc310411EINECS 261-504-6N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochlorideN-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride USP/EP/BPBenzeneacetamide, N-(4-chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl]-, monohydrochloride
R 15,8894'-Chloro-N-(1-isopropyl-4-piperidyl)-2-phenylacetanilide monohydrochloride1T1S98ONM1Lorcainide hydrochloride (USAN)UNII-1T1S98ONM1LORCAINIDE HYDROCHLORIDE [MI]LORCAINIDE HYDROCHLORIDE [MART.]Lorcainida clorhidrato [Spanish]
Database identifiers
- CAS
58934-46-6- PubChem CID
- 6917855
Properties
Computed structural properties
- Topological polar surface area
- 23.6 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 5
- Heavy atoms
- 27
- Formal charge
- 0
- Complexity
- 433
Physicochemical properties
- Melting point
- 263 ° · 263°
- storage temp.
- -20 °C · -20°C
- solubility
- Soluble in DMSO (up to 20 mg/ml), in Water (up to 20 mg/ml), or in Ethanol (up to 20 mg/ml).
- form
- White solid.
- color
- Powder
- Water Solubility
- 2 O: · H2O: 10mg/mL, clear
- Stability
- 1 year · Stable for 1 year from date of purchase as supplied. Solutions in DMSO, distilled water or ethanol may be stored at -20°C for up to 1 month
- InChI
- 1S/C22H27ClN2O.ClH/c1-17(2)24-14-12-21(13-15-24)25(20-10-8-19(23)9-11-20)22(26)16-18-6-4-3-5-7-18;/h3-11,17,21H,12-16H2,1-2H3;1H
- InChIKey
- FSFSWNBDCJVFGI-UHFFFAOYSA-N
- SMILES
- Clc1ccc(cc1)N(C3CCN(CC3)C(C)C)C(=O)Cc2ccccc2.Cl
- FDA UNII
- 1 T1S98ONM1 · 1T1S98ONM1
- UNSPSC Code
- 12352200 · 12352200
- NACRES
- 77 · NA.77
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 38 reports by companies from 1 notifications to the ECHA C&L Inventory.
Hazard information
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Safety data
- wgk
- WGK 3
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H302
- Hazard Classifications
- Acute Tox. 4 Oral
- Precautionary statements
- P264-P270-P301+P312a-P330-P501a
Chemistry & industry
Applications
DescriptionLorcainide hydrochloride (58934-46-6) is a voltage-gated Na+channel blocker.1Protects murine cultured cortical neurons from injury induced by oxygen-glucose deprivation.2Acts at the ouabain binding site of guinea pig cardiac Na+/K+ATPase and inhibits the enzyme (IC50= 34 μM).3
UsesCardiac depressant (anti-arrhythmic).
Suppliers5 total
Aladdin Scientific[email protected]
湖北扬信医药科技有限公司0714-3999001 19171453112 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
陕西缔都医药化工有限公司+86-29-81139210 +86-17392587031 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
Related reactions
9 records
Compound notes
Loading…