Basic information
- CAS
131311-25-6- Standard SMILES
CCC[n+]1cc(Br)cc(C(=O)N(CCC(=O)NCCOC(=O)N2CCc3ccccc3C2)c2ccccc2)c1.O=[N+]([O-])[O-]- InChIKey
UOZBZWREOXRQLG-UHFFFAOYSA-N- Molecular formula
- C30H34BrN5O7
- Average molar mass
- 656.5 g/mol
- Monoisotopic mass
- 655.16416
Overview
PAF antagonist
Names & identifiers
- Preferred name
- Tcv 309
- IUPAC
- 2-[3-(N-(5-bromo-1-propylpyridin-1-ium-3-carbonyl)anilino)propanoylamino]ethyl 3,4-dihydro-1H-isoquinoline-2-carboxylate nitrate
- English name
- TCV 309
- Molecular formula
- C30H36BrN5O7
- Molecular weight
- 658.54014
Names & synonyms
PYRIDINIUM, 3-BROMO-5-(((3-((2-(((3,4-DIHYDRO-2(1H)-ISOQUINOLINYL)CARBONYL)OXY)ETHYL)AMINO)-3-OXOPROPYL)PHENYLAMINO)CARBONYL)-1-PROPYL-, NITRATE (1:1)Pyridinium, 3-bromo-5-[[[3-[[2-[[(3,4-dihydro-2(1H)-isoquinolinyl)carbonyl]oxy]ethyl]amino]-3-oxopropyl]phenylamino]carbonyl]-1-propyl-, nitrate (1:1)RefChem:932626TCV 309Tcv-309131311-25-6SMQ997EQ852-[3-(N-(5-bromo-1-propylpyridin-1-ium-3-carbonyl)anilino)propanoylamino]ethyl 3,4-dihydro-1H-isoquinoline-2-carboxylate;nitrate3-Bromo-5-(N-phenyl-N-(2-((2-(1,2,3,4-tetrahydro-2-isoquinolylcarbonyloxy)ethyl)carbamoyl)ethyl)carbamoyl)-1-propylpyridinium nitrateUNII-SMQ997EQ85orb1699166SCHEMBL9051635
Show more names
TCV-309 intTCV 309 int
SCHEMBL29384283AKOS0407496223-bromo-5-((3-oxo-3-((2-((1,2,3,4-tetrahydroisoquinoline-2-carbonyl)oxy)ethyl)amino)propyl)(phenyl)carbamoyl)-1-propylpyridin-1-ium nitrateHY-19121CS-0014860T28933Q27289286Pyridinium, 3-bromo-5-(((3-((2-(((3,4-dihydro-2(1H)-isoquinolinyl)carbonyl)oxy)ethyl)amino)-3-oxopropyl)phenylamino)carbonyl)-1-propyl-, nitrate
Properties
Computed structural properties
- Topological polar surface area
- 146 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 7
- Rotatable bonds
- 11
- Heavy atoms
- 43
- Formal charge
- 0
- Complexity
- 827
Physicochemical properties
- FDA UNII
- 997 EQ85 · SMQ997EQ85
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
Applications
UsesTCV-309 is an antagonist for platelet activating factor (PAF). TCV-309 improves the left ventricular function during ischemia-reperfusion (77.6% recover at 1 μM), protects the cardiac function[1].
Suppliers8 total
上海波以尔化工有限公司[email protected]
苏州美石生物科技有限公司1173954148q · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
上海珀法姆医药科技有限公司+86 18721201413 · [email protected]
HANGZHOU CLAP TECHNOLOGY CO.,LTD86-571-88216897,88216896 13588875226 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354 · [email protected]
南京世洲生物科技有限公司025-85560043 15850508050 · [email protected]
Related reactions
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Compound notes
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