Basic information
- CAS
163680-77-1- Standard SMILES
CS(=O)(=O)O.C[C@H]1COc2c(C3(N)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23- InChIKey
UDHGFPATQWQARM-FJXQXJEOSA-N- Molecular formula
- C17H19FN2O7S
- Average molar mass
- 414.4 g/mol
- Monoisotopic mass
- 414.08970028
Names & identifiers
- Preferred name
- Pazufloxacin Mesilate
- IUPAC
- (2S)-6-(1-aminocyclopropyl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid;methanesulfonic acid
- English name
- Pazufloxacin mesilate
- Molecular formula
- C17H19FN2O7S
- Molecular weight
- 414.4053632
Names & synonyms
Pazufloxacin mesylate163680-77-1Pazufloxacin mesilatePazufloxacin methanesulfonatePasilPasil (TN)2XI226J1HSNSC 759831NSC-759831PAZUFLOXACIN METHANESULFONATE [MI]7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, methanesulfonate (1:1)DTXSID80167645
Show more names
T 3762PAZUCROSSPAZUFLOXACIN MESYLASPazufloxacin mesilatMesylate pazufloxacinPasofloxacin mesylatePazufloxacinMesylate>
PAZUFLOXACIN MESILATE [JAN]PAZUFLOXACIN MESILATE [MART.]PAZUFLOXACIN MESILATE [WHO-DD]PAZUFLOXACIN MESILATE (MART.)(-)-(3S)-10-(1-AMINOCYCLOPROPYL)-9-FLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO(1,2,3-DE)-1,4-BENZOXAZINE-6-CARBOXYLIC ACID METHANESULFONATE(-)-(3S)-10-(1-AMINOCYCLOPROPYL)-9-FLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO(1,2,3-DE)-1,4-BENZOXAZINE-6-CARBOXYLIC ACID METHANESULPHONATE(3S)-10-(1-Aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido(1,2,3-de)(1,4)benzoxazine-6-carboxylic acid monomethanesulfonate(3S)-10-(1-Aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid monomethanesulfonate
Properties
Computed structural properties
- Topological polar surface area
- 156 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 10
- Rotatable bonds
- 2
- Heavy atoms
- 28
- Formal charge
- 0
- Complexity
- 695
Physicochemical properties
- Melting point
- 255 °C · >255°C (dec.)
- alpha
- 20 · D20 -64.2° (c = 1 in 1.0N NaOH)
- storage temp.
- -20 °C · -20°C Freezer
- solubility
- Aqueous Base (Slightly), DMSO (Slightly)
- form
- Solid
- color
- Off-White to Pale Yellow
- InChIKey
- UDHGFPATQWQARM-FJXQXJEOSA-N
- SMILES
- S(C([H])([H])[H])(=O)(=O)O[H].FC1C([H])=C2C(C(C(=O)O[H])=C([H])N3[C@@]([H])(C([H])([H])[H])C([H])([H])OC(=C32)C=1C1(C([H])([H])C1([H])[H])N([H])[H])=O
- CAS DataBase Reference
- 163680 · 163680-77-1(CAS DataBase Reference)
- FDA UNII
- 2 XI226J1HS · 2XI226J1HS
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 315 · H315-H319-H335
- Precautionary statements
- 261 · P261-P305+P351+P338
- Hazard Codes
- Xi,C,F
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Hazard Classes and CategoriesSkin Irrit. 2 (100%)
Safety data
- rtecs
- UU8815400
- hs_code
- 29349990
- risk_code
- 36/37/38-34-11
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xi,C,F
- safety_code
- 26-45-36/37/39-16
- Hazard statements
- H315-H319-H335
- Precautionary statements
- P261-P305+P351+P338
Chemistry & industry
Applications
DescriptionThis fluoroquinolone was co-developed by Toyama and Mitsubishi Pharm and was launched for the intravenous therapy of respiratory, urinary, surgical, gynecological and systemic infections.
DescriptionPazufloxacin is a broad-spectrum synthetic fluoroquinolone antibiotic. It is active against Gram-negative and Gram-positive bacteria, including clinical isolates of E. coli, K. pneumoniae, methicillin-susceptible and -resistant S. aureus, and methicillin-susceptible and -resistant S. epidermidis (MIC90s = 0.05, 0.1, 0.39, 12.5, 0.39, and 6.25 μg/ml, respectively). It inhibits E. coli, P. aeruginosa, and S. aureus DNA gyrase (IC50s = 0.88, 1.9, and 10.2 μg/ml, respectively) and S. aureus topoisomerase IV (IC50 = 24.2 μg/ml) in cell-free assays. In vivo, pazufloxacin is active against systemic E. coli, K. pneumoniae, and methicillin-resistant S. aureus infections in mice (ED50s = 0.15, 5.5, and 4.5 mg/kg, respectively).
UsesA fluorinated quinolone antibiotic. Antibacterial.
Suppliers100 total
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
济南百隆化学有限公司[email protected] · [email protected]
HubeiwidelychemicaltechnologyCo.,Ltd18627774460 · [email protected]
广州隽沐生物科技股份有限公司020-36607679; 13502246435 · [email protected]
Hong Kong Tiansheng New Material Trading Co., Ltd+8617320695765 · [email protected]
Related reactions
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Compound notes
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