Phenserine tartrate
Basic information
- CAS
156910-61-1- Standard SMILES
CN1CC[C@@]2(C)c3cc(OC(=O)Nc4ccccc4)ccc3N(C)[C@@H]12.O=C(O)[C@H](O)[C@@H](O)C(=O)O- InChIKey
XKKPTCVQEJZDGT-PWUAAHBCSA-N- Molecular formula
- C24H29N3O8
- Average molar mass
- 487.5 g/mol
- Monoisotopic mass
- 487.19546489
Names & identifiers
- Preferred name
- Phenserine tartrate
- IUPAC
- [(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-phenylcarbamate;(2R,3R)-2,3-dihydroxybutanedioic acid
- English name
- Tartrate
- Molecular formula
- C4H4O6-2
- Molecular weight
- 148.07096
Names & synonyms
Phenserine tartratePhenserine (-)-tartrateUNII-A2TJL9CO2KA2TJL9CO2K156910-61-1PHENSERINE (+)-TARTRATEPHENSERINE TARTRATE [MI](-)-PHENSERINE (+)-TARTRATEPyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, phenylcarbamate (ester), (3aS,8aR)-, (2S,3S)-2,3-dihydroxybutanedioate (salt)Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, phenylcarbamate (ester), (3aS-cis)-, (S-(R*,R*))-2,3-dihydroxybutanedioate (salt)PYRROLO(2,3-B)INDOL-5-OL, 1,2,3,3A,8,8A-HEXAHYDRO-1,3A,8-TRIMETHYL-, 5-(N-PHENYLCARBAMATE), (3AS,8AR)-, (2R,3R)-2,3-DIHYDROXYBUTANEDIOATE (1:1)PYRROLO(2,3-B)INDOL-5-OL, 1,2,3,3A,8,8A-HEXAHYDRO-1,3A,8-TRIMETHYL-, PHENYLCARBAMATE (ESTER), (3AS,8AR)-, (2R,3R)-2,3-DIHYDROXYBUTANEDIOATE (SALT)
Show more names
RefChem:172922phenserine.tartaric acidPhenserine (tartrate)orb2664200HY-103374AT89337Q27273542
Database identifiers
- CAS
156910-61-1- PubChem CID
- 6918263
- UNII
- A2TJL9CO2K
Properties
Computed structural properties
- Topological polar surface area
- 160 Ų
- Hydrogen bond donors
- 5
- Hydrogen bond acceptors
- 10
- Rotatable bonds
- 6
- Heavy atoms
- 35
- Formal charge
- 0
- Complexity
- 641
Physicochemical properties
- Melting point
- 142 · 142-145°
- alpha
- -58.7 ° · D -58.7° (c = 0.75 in methanol)
- FDA UNII
- 2 TJL9CO2K · A2TJL9CO2K
Chemistry & industry
Applications
UsesPhenserine tartrate ((-)-Eseroline phenylcarbamate) is a derivative of Physostigmine and is a potent, noncompetitive, long-acting and selective AChE inhibitor. Phenserine tartrate reduces β-amyloid precursor protein (APP) and β-amyloid peptide (Aβ) formation. Phenserine tartrate improves cognitive performance and attenuates the progression of Alzheimer's disease[1][2][3].
Related reactions
0 records
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Compound notes
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