4-Methylpiperidine

HCID 69381CAS 626-58-4
Substructure searchFind similar structures

Basic information

Standard SMILES
CC1CCNCC1
InChIKey
UZOFELREXGAFOI-UHFFFAOYSA-N
Molecular formula
C6H13N
Average molar mass
99.17 g/mol
Monoisotopic mass
99.10479942

Names & identifiers

Preferred name
4-Methylpiperidine
IUPAC
4-methylpiperidine
English name
4-Methylpiperidine
Molecular formula
C6H13N
Molecular weight
99.17

Names & synonyms

4-Methylpiperidine626-58-44-PipecolinePiperidine, 4-methyl-gamma-PipecolineEV6HN6HDP8NSC-66495DTXSID8060820RefChem:99934DTXCID6043418210-954-1.gamma.-Pipecoline
Show more names
4PPC4-Methylpiperidine solution4Me-Pipg-PipecolineAKOS BBS-000036664-methyl-piperidin
4-Methyl-piperidine4-methylpiperidin4-Methylpiperidine--d4MFCD00006005?-Pipecoline4-methylpiperdine4-methylpyperidine4-Pipecoline; 4-Methylpiperidine; NSC 126910; NSC 66495; gamma-Pipecoline

Database identifiers

CAS
626-58-4
PubChem CID
69381
DTXSID
DTXSID8060820
ChEMBL
CHEMBL21533
UNII
EV6HN6HDP8
EC Number
210-954-1
Nikkaji
J6.864K

Properties

Computed structural properties

XLogP
1.1
Topological polar surface area
12 Ų
Hydrogen bond donors
1
Hydrogen bond acceptors
1
Rotatable bonds
0
Heavy atoms
7

Experimental & physicochemical properties

Physical DescriptionColorless liquid with an amine-like odor; [Alfa Aesar MSDS]
Kovats Retention Index · 2 items

831；816；816

1077；1075

Physicochemical properties

Melting point
4 · 4-5 °C
Boiling point
124 °C · 124 °C(lit.)
Density
0.838 g/mL · 0.838 g/mL at 25 °C(lit.)
vapor pressure
16 hPa · 16 hPa (20 °C)
refractive index
20 · n20/D 1.446(lit.)
Flash point
45 °F · 45 °F

Safety & regulation

GHS classification

GHS Classification · 5 items

Danger

H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]；H302 (12.3%): Harmful if swallowed [Warning Acute toxicity, oral]；H314 (27.7%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]；H315 (70.8%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (70.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (70.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P316, P319, P321, P330, P332+P317, P337+P317, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 65 reports by companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Regulatory Information · 3 items

Chemical: Piperidine, 4-methyl-

Status: Active Update: 13-05-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/19405

4-Methylpiperidine: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryCauses burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; [Alfa Aesar MSDS] See Piperidine.
Hazard Classes and CategoriesFlam. Liq. 2 (100%)；Acute Tox. 4 (12.3%)；Skin Corr. 1A (27.7%)；Skin Irrit. 2 (70.8%)；Eye Irrit. 2 (70.8%)；STOT SE 3 (70.8%)

Toxicology

Adverse EffectsDermatotoxin - Skin burns.；Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

Regulatory information

Regulatory Information · 3 items

Chemical: Piperidine, 4-methyl-

Status: Active Update: 13-05-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/19405

4-Methylpiperidine: Does not have an individual approval but may be used under an appropriate group standard

Safety data

PPE
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
wgk
3
tsca
TSCA listed
ridadr
UN 1993 3/PG 2
hs_code
29333999
risk_code
11-36/37/38-36-20/21-10-61

Chemistry & industry

Uses & manufacturing

General Manufacturing InformationPiperidine, 4-methyl-: ACTIVE
Applications · 2 items

Uses4-Methylpiperidine acts as a catalyst in the preparation of stilbene derivatives. It is used as an anti-corrosive compound for iron. It is also used in the synthesis of peptides to remove or deprotection of 9-fluorenylmethyloxycarbonyl (Fmoc) groups.

Uses4-Methylpiperidine is used as a catalyst in the synthesis of stilbene derivatives as anti-malarial agents. It also serves as an anti-corrosive compound for iron.

Upstream & downstream products

Suppliers50 total

山东玖玥生物科技有限公司15553333686
国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
阿诺西（上海）生物技术有限公司400-1107768 15058188853 · [email protected]
Shandong chuangyingchemical Co., Ltd.18853181302 · [email protected]

Related reactions

368 records
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Linked notes

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