4-Methylpiperidine
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Basic information
- CAS
626-58-4- Standard SMILES
CC1CCNCC1- InChIKey
UZOFELREXGAFOI-UHFFFAOYSA-N- Molecular formula
- C6H13N
- Average molar mass
- 99.17 g/mol
- Monoisotopic mass
- 99.10479942
Names & identifiers
- Preferred name
- 4-Methylpiperidine
- IUPAC
- 4-methylpiperidine
- English name
- 4-Methylpiperidine
- Molecular formula
- C6H13N
- Molecular weight
- 99.17
Names & synonyms
4-Methylpiperidine626-58-44-PipecolinePiperidine, 4-methyl-gamma-PipecolineEV6HN6HDP8NSC-66495DTXSID8060820RefChem:99934DTXCID6043418210-954-1.gamma.-Pipecoline
Show more names
4PPC4-Methylpiperidine solution4Me-Pipg-PipecolineAKOS BBS-000036664-methyl-piperidin
4-Methyl-piperidine4-methylpiperidin4-Methylpiperidine--d4MFCD00006005?-Pipecoline4-methylpiperdine4-methylpyperidine4-Pipecoline; 4-Methylpiperidine; NSC 126910; NSC 66495; gamma-Pipecoline
Database identifiers
- CAS
626-58-4- PubChem CID
- 69381
- DTXSID
DTXSID8060820- ChEMBL
CHEMBL21533- UNII
- EV6HN6HDP8
- EC Number
- 210-954-1
- Nikkaji
- J6.864K
Properties
Computed structural propertiesFilling in
- XLogP
- 1.1
- Topological polar surface area
- 12 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 1
- Rotatable bonds
- 0
- Heavy atoms
- 7
- Formal charge
- 0
- Complexity
- 46
Experimental & physicochemical properties
Physical DescriptionColorless liquid with an amine-like odor; [Alfa Aesar MSDS]
Kovats Retention Index
831；816；816
1077；1075
Physicochemical properties
- Melting point
- 4 · 4-5 °C
- Boiling point
- 124 °C · 124 °C(lit.)
- Density
- 0.838 g/mL · 0.838 g/mL at 25 °C(lit.)
- vapor pressure
- 16 hPa · 16 hPa (20 °C)
- refractive index
- 20 · n20/D 1.446(lit.)
- Flash point
- 45 °F · 45 °F
- storage temp.
- Flammables area
- solubility
- Chloroform
- form
- Liquid
- pka
- 1 · pK1:11.23(+1) (25°C,μ=0.5)
- Specific Gravity
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Danger
H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]；H302 (12.3%): Harmful if swallowed [Warning Acute toxicity, oral]；H314 (27.7%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]；H315 (70.8%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (70.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (70.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P316, P319, P321, P330, P332+P317, P337+P317, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 65 reports by companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
Hazard information
Regulatory Information
Chemical: Piperidine, 4-methyl-
Status: Active Update: 13-05-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/19405
4-Methylpiperidine: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryCauses burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; [Alfa Aesar MSDS] See Piperidine.
Chemistry & industry
Uses & manufacturing
General Manufacturing InformationPiperidine, 4-methyl-: ACTIVE
Applications
Uses4-Methylpiperidine acts as a catalyst in the preparation of stilbene derivatives. It is used as an anti-corrosive compound for iron. It is also used in the synthesis of peptides to remove or deprotection of 9-fluorenylmethyloxycarbonyl (Fmoc) groups.
Uses4-Methylpiperidine is used as a catalyst in the synthesis of stilbene derivatives as anti-malarial agents. It also serves as an anti-corrosive compound for iron.
Upstream & downstream products
Downstream products
Related reactions
368 records
Compound notes
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