Basic information
- CAS
632-69-9- Standard SMILES
O=C1OC2(c3cc(I)c([O-])c(I)c3Oc3c2cc(I)c([O-])c3I)c2c(Cl)c(Cl)c(Cl)c(Cl)c21.[Na+].[Na+]- InChIKey
KCQREHTWEUECQT-UHFFFAOYSA-L- Molecular formula
- C20H2Cl4I4Na2O5
- Average molar mass
- 1,017.6 g/mol
- Monoisotopic mass
- 1,015.4631
Names & identifiers
- Preferred name
- rose bengal disodium salt
- IUPAC
- disodium;4,5,6,7-tetrachloro-2',4',5',7'-tetraiodo-3-oxospiro[2-benzofuran-1,9'-xanthene]-3',6'-diolate
- English name
- Acid Red 94
- Molecular formula
- C20H5Cl4I4NaO5
- Molecular weight
- 997.66
Names & synonyms
XantrylRose bengal disodium saltR105 sodiumFood Red No. 105, sodium saltRose-bengal (131 I) natriumPV 10EINECS 211-183-3Rose bengale (131 I) sodique [INN-French]Food Red Color No. 105, sodium saltRosa bengala sodica (131 I)Rose bengale (131 I) sodiqueRosa bengala sodica (131 I) [INN-Spanish]
Show more names
ROSE BENGALRBBENGAL ROSERose redROSE BENGAL SODIUM SALTROSE BENGALETNF-α ELISACI 45440LTB4 ELISA
Sel disodique de rose bengale iodee (131 I)Roseum bengalense (131 I) natricumRoseum bengalense (131 I) natricum [INN-Latin]2,4,5,7-Tetraido(m,p,o',m')tetrachlorofluorescein, disodium salt9-(3',4',5',6'-Tetrachloro-o-carboxyphenyl)-6-hydroxy-2,4,5,7-tetraiodo-3-isoxanthone 2NaNSC 270091Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-, disodium saltSpiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-, disodium salt
Properties
Computed structural properties
- Topological polar surface area
- 81.7 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 0
- Heavy atoms
- 35
- Formal charge
- 0
- Complexity
- 780
Physicochemical properties
- Melting point
- 300 °C · >300°C
- storage temp.
- 15 °C · Store at +15°C to +30°C.
- solubility
- 2 O: · H2O: soluble1mg/mL
- Colour Index
- 45440 · 45440
- form
- Solid
- pka
- 3.9 · 3.9, 4.7(at 25℃)
- color
- Red-brown
- Water Solubility
- soluble
- Sensitive
- Light Sensitive
- λmax
- 548 nm · 548 nm
- ε(extinction coefficient)
- 90000 at · ≥90000 at 546-550nm at 0.008g/L
- Merck
- 14 · 14,8262
- BRN
- 3645857 · 3645857
- Biological Applications
- Apoptosis assay; diagnosis of diseases related to amyloid accumulation; controlling plant diseases; identifying fungi; treating skin,mouth,digestive tract,urinary tract,reproductive tract,respiratory tract,circulatory system
- Major Application
- diagnostic assay manufacturinghematologyhistology
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- F
- 8
- PPE
- Eyeshields, Gloves, type N95 (US)
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- LM5920000
- ridadr
- UN 3264 8 / PGIII
- hs_code
- 32129000
- risk_code
- 36-36/38
- Signal word
- Warning
- Symbol(GHS)
- GHS05
- hazard_code
- Xi
- safety_code
- 22-24/25-37/39-26
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H290
- Precautionary statements
- P234-P390
Chemistry & industry
Applications
DescriptionRose bengal is a xanthene dye, fluorescein derivative, and photosensitizer. It exhibits absorption/emission maxima of 548/567 nm, respectively. Rose bengal binds to S. aureus cells and decreases survival of photoirradiated S. aureus to 0.012% when used at a concentration of 1 μM. It generates singlet oxygen when exposed to photoirradiation in cell-free assays and induces potassium ion leakage from S. aureus and bovine erythrocytes in the presence of photoirradiation. Rose bengal inhibits the cytochrome P450 (CYP) isoform CYP3A4/5 and the UDP-glucuronosyltransferase (UGT) isoform UGT1A6 in human liver microsomes in a light-dependent manner, with IC50 values of 0.072 and 0.035 μM, respectively, in yellow light, 3.1 and 4.2 μM, respectively, in ambient light, and 3 and 4.2 μM, respectively, in the dark. It has been used for staining of live cells, but exhibits both intrinsic and phototoxicity.
UsesFor research use only. Not for use in diagnostic procedures.Please refer to the attached Protocolfor details.
UsesRose Bengal Sodium Salt is used in biological studies as potential for use as sensitizers in photodynamic and sonodynamic therapy by synthesizing Rose Bengal amphiphilic derivatives. This compound has neuroprotective properties.
General DescriptionThis ELISA antibody pair detects Bovine IGF-1
Upstream & downstream products
Upstream raw materials
Related reactions
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Compound notes
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